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Gene: TMEM141 |
Gene summary for TMEM141 |
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Gene information | Species | Human | Gene symbol | TMEM141 | Gene ID | 85014 |
Gene name | transmembrane protein 141 | |
Gene Alias | TMEM141 | |
Cytomap | 9q34.3 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | Q96I45 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
85014 | TMEM141 | GSM4909281 | Human | Breast | IDC | 1.35e-02 | 1.49e-01 | 0.21 |
85014 | TMEM141 | GSM4909287 | Human | Breast | IDC | 1.92e-02 | -2.71e-01 | 0.2057 |
85014 | TMEM141 | GSM4909291 | Human | Breast | IDC | 4.12e-08 | 4.47e-01 | 0.1753 |
85014 | TMEM141 | GSM4909293 | Human | Breast | IDC | 5.01e-21 | 5.48e-01 | 0.1581 |
85014 | TMEM141 | GSM4909294 | Human | Breast | IDC | 2.44e-03 | 2.04e-01 | 0.2022 |
85014 | TMEM141 | GSM4909296 | Human | Breast | IDC | 4.69e-09 | 3.01e-01 | 0.1524 |
85014 | TMEM141 | GSM4909297 | Human | Breast | IDC | 8.13e-08 | -7.00e-02 | 0.1517 |
85014 | TMEM141 | GSM4909304 | Human | Breast | IDC | 6.51e-11 | 4.92e-01 | 0.1636 |
85014 | TMEM141 | GSM4909306 | Human | Breast | IDC | 9.40e-13 | 4.43e-01 | 0.1564 |
85014 | TMEM141 | GSM4909308 | Human | Breast | IDC | 1.93e-02 | 2.44e-01 | 0.158 |
85014 | TMEM141 | GSM4909311 | Human | Breast | IDC | 1.19e-15 | -1.25e-01 | 0.1534 |
85014 | TMEM141 | GSM4909312 | Human | Breast | IDC | 1.86e-06 | 4.46e-02 | 0.1552 |
85014 | TMEM141 | GSM4909313 | Human | Breast | IDC | 1.25e-02 | 1.68e-01 | 0.0391 |
85014 | TMEM141 | GSM4909315 | Human | Breast | IDC | 5.52e-08 | 4.07e-01 | 0.21 |
85014 | TMEM141 | GSM4909316 | Human | Breast | IDC | 5.13e-07 | 4.26e-01 | 0.21 |
85014 | TMEM141 | GSM4909319 | Human | Breast | IDC | 1.37e-27 | -2.61e-02 | 0.1563 |
85014 | TMEM141 | GSM4909321 | Human | Breast | IDC | 1.86e-09 | 6.62e-02 | 0.1559 |
85014 | TMEM141 | brca2 | Human | Breast | Precancer | 6.94e-06 | 1.89e-01 | -0.024 |
85014 | TMEM141 | M2 | Human | Breast | IDC | 1.55e-03 | 3.40e-01 | 0.21 |
85014 | TMEM141 | NCCBC14 | Human | Breast | DCIS | 3.64e-03 | -6.39e-03 | 0.2021 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TMEM141 | SNV | Missense_Mutation | novel | c.182N>G | p.Gln61Arg | p.Q61R | Q96I45 | protein_coding | tolerated(0.08) | benign(0.005) | TCGA-AA-3955-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | capecitabine | CR |
TMEM141 | SNV | Missense_Mutation | c.176N>A | p.Pro59His | p.P59H | Q96I45 | protein_coding | deleterious(0.03) | benign(0.292) | TCGA-AP-A059-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
TMEM141 | SNV | Missense_Mutation | c.93C>A | p.Phe31Leu | p.F31L | Q96I45 | protein_coding | tolerated(0.3) | probably_damaging(0.971) | TCGA-EY-A1GS-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Chemotherapy | taxol | PD | |
TMEM141 | SNV | Missense_Mutation | novel | c.83N>T | p.Ser28Leu | p.S28L | Q96I45 | protein_coding | deleterious(0) | probably_damaging(0.991) | TCGA-05-4427-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Chemotherapy | cisplatin | CR |
TMEM141 | SNV | Missense_Mutation | novel | c.160A>G | p.Arg54Gly | p.R54G | Q96I45 | protein_coding | deleterious(0) | possibly_damaging(0.501) | TCGA-VQ-A91S-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Chemotherapy | fluorouracil | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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