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Gene: TMEM136 |
Gene summary for TMEM136 |
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Gene information | Species | Human | Gene symbol | TMEM136 | Gene ID | 219902 |
Gene name | TLC domain containing 5 | |
Gene Alias | TMEM136 | |
Cytomap | 11q23.3 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | Q6ZRR5 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
219902 | TMEM136 | P2T-E | Human | Esophagus | ESCC | 4.42e-09 | 1.42e-01 | 0.1177 |
219902 | TMEM136 | P4T-E | Human | Esophagus | ESCC | 3.59e-26 | 6.84e-01 | 0.1323 |
219902 | TMEM136 | P5T-E | Human | Esophagus | ESCC | 5.59e-24 | 5.21e-01 | 0.1327 |
219902 | TMEM136 | P8T-E | Human | Esophagus | ESCC | 6.53e-06 | 9.16e-02 | 0.0889 |
219902 | TMEM136 | P10T-E | Human | Esophagus | ESCC | 7.96e-09 | 1.59e-01 | 0.116 |
219902 | TMEM136 | P11T-E | Human | Esophagus | ESCC | 3.13e-11 | 4.32e-01 | 0.1426 |
219902 | TMEM136 | P12T-E | Human | Esophagus | ESCC | 1.45e-12 | 2.70e-01 | 0.1122 |
219902 | TMEM136 | P15T-E | Human | Esophagus | ESCC | 5.17e-03 | 1.82e-01 | 0.1149 |
219902 | TMEM136 | P16T-E | Human | Esophagus | ESCC | 1.23e-09 | 1.40e-01 | 0.1153 |
219902 | TMEM136 | P22T-E | Human | Esophagus | ESCC | 1.12e-16 | 3.43e-01 | 0.1236 |
219902 | TMEM136 | P23T-E | Human | Esophagus | ESCC | 1.78e-03 | 1.12e-01 | 0.108 |
219902 | TMEM136 | P24T-E | Human | Esophagus | ESCC | 8.34e-03 | 1.12e-01 | 0.1287 |
219902 | TMEM136 | P26T-E | Human | Esophagus | ESCC | 3.07e-14 | 3.29e-01 | 0.1276 |
219902 | TMEM136 | P27T-E | Human | Esophagus | ESCC | 1.44e-04 | 8.92e-02 | 0.1055 |
219902 | TMEM136 | P28T-E | Human | Esophagus | ESCC | 3.77e-05 | 1.57e-01 | 0.1149 |
219902 | TMEM136 | P30T-E | Human | Esophagus | ESCC | 3.28e-06 | 2.72e-01 | 0.137 |
219902 | TMEM136 | P37T-E | Human | Esophagus | ESCC | 3.13e-07 | 1.23e-01 | 0.1371 |
219902 | TMEM136 | P47T-E | Human | Esophagus | ESCC | 8.51e-06 | 1.12e-01 | 0.1067 |
219902 | TMEM136 | P49T-E | Human | Esophagus | ESCC | 3.21e-10 | 8.78e-01 | 0.1768 |
219902 | TMEM136 | P57T-E | Human | Esophagus | ESCC | 3.06e-04 | 1.46e-01 | 0.0926 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TMEM136 | SNV | Missense_Mutation | novel | c.536G>A | p.Gly179Glu | p.G179E | Q6ZRR5 | protein_coding | deleterious(0.02) | probably_damaging(0.988) | TCGA-AC-A5XS-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | femara | SD |
TMEM136 | SNV | Missense_Mutation | novel | c.729N>T | p.Lys243Asn | p.K243N | Q6ZRR5 | protein_coding | deleterious(0.03) | benign(0.037) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TMEM136 | insertion | Frame_Shift_Ins | novel | c.442_443insATAGGATCCC | p.Val148AspfsTer12 | p.V148Dfs*12 | Q6ZRR5 | protein_coding | TCGA-A8-A083-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
TMEM136 | deletion | Frame_Shift_Del | novel | c.363delN | p.Ala122ProfsTer2 | p.A122Pfs*2 | Q6ZRR5 | protein_coding | TCGA-D8-A27V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | ||
TMEM136 | SNV | Missense_Mutation | c.214N>A | p.Leu72Ile | p.L72I | Q6ZRR5 | protein_coding | tolerated(0.16) | possibly_damaging(0.612) | TCGA-AA-3713-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | 5-fluorouracil | PR | |
TMEM136 | SNV | Missense_Mutation | c.490N>C | p.Met164Leu | p.M164L | Q6ZRR5 | protein_coding | tolerated(0.88) | benign(0) | TCGA-AM-5821-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
TMEM136 | insertion | Frame_Shift_Ins | novel | c.557_558insCGAC | p.Val187AspfsTer20 | p.V187Dfs*20 | Q6ZRR5 | protein_coding | TCGA-AA-A02K-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | folinic | PD | ||
TMEM136 | SNV | Missense_Mutation | novel | c.374T>A | p.Leu125Gln | p.L125Q | Q6ZRR5 | protein_coding | deleterious(0) | probably_damaging(0.986) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TMEM136 | SNV | Missense_Mutation | novel | c.475A>G | p.Asn159Asp | p.N159D | Q6ZRR5 | protein_coding | deleterious(0.02) | probably_damaging(0.993) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TMEM136 | SNV | Missense_Mutation | novel | c.143N>C | p.Leu48Pro | p.L48P | Q6ZRR5 | protein_coding | tolerated(0.2) | possibly_damaging(0.748) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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