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Gene: TMEM132A |
Gene summary for TMEM132A |
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Gene information | Species | Human | Gene symbol | TMEM132A | Gene ID | 54972 |
Gene name | transmembrane protein 132A | |
Gene Alias | GBP | |
Cytomap | 11q12.2 | |
Gene Type | protein-coding | GO ID | GO:0008150 | UniProtAcc | Q24JP5 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
54972 | TMEM132A | LZE21D1 | Human | Esophagus | HGIN | 2.03e-03 | 2.18e-01 | 0.0632 |
54972 | TMEM132A | LZE24T | Human | Esophagus | ESCC | 8.60e-05 | 8.47e-02 | 0.0596 |
54972 | TMEM132A | P1T-E | Human | Esophagus | ESCC | 3.24e-03 | 1.62e-01 | 0.0875 |
54972 | TMEM132A | P2T-E | Human | Esophagus | ESCC | 2.21e-18 | 3.13e-01 | 0.1177 |
54972 | TMEM132A | P4T-E | Human | Esophagus | ESCC | 4.74e-10 | 3.64e-01 | 0.1323 |
54972 | TMEM132A | P5T-E | Human | Esophagus | ESCC | 3.61e-02 | 2.46e-02 | 0.1327 |
54972 | TMEM132A | P8T-E | Human | Esophagus | ESCC | 1.45e-02 | 5.18e-02 | 0.0889 |
54972 | TMEM132A | P9T-E | Human | Esophagus | ESCC | 2.94e-04 | 2.59e-01 | 0.1131 |
54972 | TMEM132A | P10T-E | Human | Esophagus | ESCC | 1.76e-06 | 1.03e-01 | 0.116 |
54972 | TMEM132A | P11T-E | Human | Esophagus | ESCC | 7.93e-10 | 4.83e-01 | 0.1426 |
54972 | TMEM132A | P12T-E | Human | Esophagus | ESCC | 7.10e-17 | 3.46e-01 | 0.1122 |
54972 | TMEM132A | P15T-E | Human | Esophagus | ESCC | 9.03e-17 | 4.29e-01 | 0.1149 |
54972 | TMEM132A | P16T-E | Human | Esophagus | ESCC | 1.96e-14 | 2.21e-01 | 0.1153 |
54972 | TMEM132A | P17T-E | Human | Esophagus | ESCC | 6.68e-05 | 2.05e-01 | 0.1278 |
54972 | TMEM132A | P20T-E | Human | Esophagus | ESCC | 9.97e-13 | 2.12e-01 | 0.1124 |
54972 | TMEM132A | P21T-E | Human | Esophagus | ESCC | 6.63e-09 | 1.70e-01 | 0.1617 |
54972 | TMEM132A | P22T-E | Human | Esophagus | ESCC | 9.64e-07 | 7.80e-02 | 0.1236 |
54972 | TMEM132A | P23T-E | Human | Esophagus | ESCC | 1.45e-04 | 8.45e-02 | 0.108 |
54972 | TMEM132A | P24T-E | Human | Esophagus | ESCC | 2.34e-09 | 1.48e-01 | 0.1287 |
54972 | TMEM132A | P26T-E | Human | Esophagus | ESCC | 4.24e-12 | 1.75e-01 | 0.1276 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TMEM132A | SNV | Missense_Mutation | c.874G>A | p.Val292Met | p.V292M | Q24JP5 | protein_coding | deleterious(0) | benign(0.329) | TCGA-A8-A08F-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | 5-fluorouracil | CR | |
TMEM132A | SNV | Missense_Mutation | c.218C>G | p.Ser73Cys | p.S73C | Q24JP5 | protein_coding | deleterious(0) | possibly_damaging(0.8) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
TMEM132A | SNV | Missense_Mutation | novel | c.2393N>G | p.Val798Gly | p.V798G | Q24JP5 | protein_coding | tolerated(0.47) | benign(0) | TCGA-AN-A0G0-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TMEM132A | SNV | Missense_Mutation | rs763174302 | c.1892N>T | p.Thr631Met | p.T631M | Q24JP5 | protein_coding | deleterious(0.02) | probably_damaging(0.958) | TCGA-AO-A128-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD |
TMEM132A | insertion | Nonsense_Mutation | novel | c.1261_1262insGGTAGGGA | p.His421ArgfsTer2 | p.H421Rfs*2 | Q24JP5 | protein_coding | TCGA-A8-A08H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
TMEM132A | insertion | In_Frame_Ins | novel | c.1111_1112insGCTTCA | p.Gln371delinsArgPheLys | p.Q371delinsRFK | Q24JP5 | protein_coding | TCGA-BH-A0B1-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | adriamycin | SD | ||
TMEM132A | insertion | Frame_Shift_Ins | novel | c.1113_1114insGGCTCCAGGCACCACACCACCCTCATCAC | p.Leu372GlyfsTer49 | p.L372Gfs*49 | Q24JP5 | protein_coding | TCGA-BH-A0B1-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | adriamycin | SD | ||
TMEM132A | SNV | Missense_Mutation | c.1956N>C | p.Leu652Phe | p.L652F | Q24JP5 | protein_coding | deleterious(0) | probably_damaging(0.988) | TCGA-DR-A0ZM-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unspecific | Cisplatin | SD | |
TMEM132A | SNV | Missense_Mutation | rs760024959 | c.2263N>T | p.Arg755Cys | p.R755C | Q24JP5 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-EA-A1QT-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
TMEM132A | SNV | Missense_Mutation | novel | c.1907N>T | p.Ser636Leu | p.S636L | Q24JP5 | protein_coding | deleterious(0.03) | probably_damaging(0.963) | TCGA-JW-A5VL-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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