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Gene: TMEM129 |
Gene summary for TMEM129 |
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Gene information | Species | Human | Gene symbol | TMEM129 | Gene ID | 92305 |
Gene name | transmembrane protein 129, E3 ubiquitin ligase | |
Gene Alias | D4S2561E | |
Cytomap | 4p16.3 | |
Gene Type | protein-coding | GO ID | GO:0000209 | UniProtAcc | A0AVI4 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
92305 | TMEM129 | HTA11_347_2000001011 | Human | Colorectum | AD | 4.84e-07 | 2.10e-01 | -0.1954 |
92305 | TMEM129 | HTA11_696_2000001011 | Human | Colorectum | AD | 1.20e-03 | 2.33e-01 | -0.1464 |
92305 | TMEM129 | HTA11_1391_2000001011 | Human | Colorectum | AD | 6.39e-08 | 3.67e-01 | -0.059 |
92305 | TMEM129 | HTA11_866_3004761011 | Human | Colorectum | AD | 1.31e-04 | 2.02e-01 | 0.096 |
92305 | TMEM129 | HTA11_8622_2000001021 | Human | Colorectum | SER | 1.00e-02 | 2.84e-01 | 0.0528 |
92305 | TMEM129 | HTA11_10623_2000001011 | Human | Colorectum | AD | 2.85e-06 | 5.20e-01 | -0.0177 |
92305 | TMEM129 | HTA11_6801_2000001011 | Human | Colorectum | SER | 1.93e-06 | 5.54e-01 | 0.0171 |
92305 | TMEM129 | HTA11_7696_3000711011 | Human | Colorectum | AD | 3.31e-08 | 3.24e-01 | 0.0674 |
92305 | TMEM129 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 2.13e-12 | 3.79e-01 | 0.3859 |
92305 | TMEM129 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 3.35e-08 | 3.25e-01 | 0.3005 |
92305 | TMEM129 | C21 | Human | Oral cavity | OSCC | 3.13e-08 | 3.95e-01 | 0.2678 |
92305 | TMEM129 | C30 | Human | Oral cavity | OSCC | 7.85e-25 | 1.05e+00 | 0.3055 |
92305 | TMEM129 | C38 | Human | Oral cavity | OSCC | 5.85e-10 | 7.38e-01 | 0.172 |
92305 | TMEM129 | C43 | Human | Oral cavity | OSCC | 2.98e-23 | 4.80e-01 | 0.1704 |
92305 | TMEM129 | C46 | Human | Oral cavity | OSCC | 2.71e-17 | 4.72e-01 | 0.1673 |
92305 | TMEM129 | C51 | Human | Oral cavity | OSCC | 1.61e-16 | 7.25e-01 | 0.2674 |
92305 | TMEM129 | C57 | Human | Oral cavity | OSCC | 2.96e-02 | 2.28e-01 | 0.1679 |
92305 | TMEM129 | C06 | Human | Oral cavity | OSCC | 4.12e-03 | 8.85e-01 | 0.2699 |
92305 | TMEM129 | C08 | Human | Oral cavity | OSCC | 3.31e-08 | 2.37e-01 | 0.1919 |
92305 | TMEM129 | C09 | Human | Oral cavity | OSCC | 1.52e-03 | 2.33e-01 | 0.1431 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0010498 | Colorectum | AD | proteasomal protein catabolic process | 174/3918 | 490/18723 | 3.18e-14 | 7.66e-12 | 174 |
GO:0043161 | Colorectum | AD | proteasome-mediated ubiquitin-dependent protein catabolic process | 141/3918 | 412/18723 | 1.77e-10 | 1.68e-08 | 141 |
GO:0034976 | Colorectum | AD | response to endoplasmic reticulum stress | 90/3918 | 256/18723 | 8.48e-08 | 4.28e-06 | 90 |
GO:0000209 | Colorectum | AD | protein polyubiquitination | 78/3918 | 236/18723 | 8.71e-06 | 2.06e-04 | 78 |
GO:0035966 | Colorectum | AD | response to topologically incorrect protein | 54/3918 | 159/18723 | 8.85e-05 | 1.36e-03 | 54 |
GO:0006986 | Colorectum | AD | response to unfolded protein | 45/3918 | 137/18723 | 7.43e-04 | 7.48e-03 | 45 |
GO:0036503 | Colorectum | AD | ERAD pathway | 34/3918 | 107/18723 | 5.57e-03 | 3.63e-02 | 34 |
GO:00104981 | Colorectum | SER | proteasomal protein catabolic process | 132/2897 | 490/18723 | 3.08e-11 | 5.55e-09 | 132 |
GO:00349761 | Colorectum | SER | response to endoplasmic reticulum stress | 74/2897 | 256/18723 | 3.01e-08 | 2.05e-06 | 74 |
GO:00431611 | Colorectum | SER | proteasome-mediated ubiquitin-dependent protein catabolic process | 105/2897 | 412/18723 | 7.48e-08 | 4.70e-06 | 105 |
GO:00359661 | Colorectum | SER | response to topologically incorrect protein | 46/2897 | 159/18723 | 1.14e-05 | 3.63e-04 | 46 |
GO:00069861 | Colorectum | SER | response to unfolded protein | 38/2897 | 137/18723 | 1.68e-04 | 3.16e-03 | 38 |
GO:00002091 | Colorectum | SER | protein polyubiquitination | 58/2897 | 236/18723 | 1.69e-04 | 3.18e-03 | 58 |
GO:0030970 | Colorectum | SER | retrograde protein transport, ER to cytosol | 12/2897 | 29/18723 | 7.22e-04 | 9.44e-03 | 12 |
GO:1903513 | Colorectum | SER | endoplasmic reticulum to cytosol transport | 12/2897 | 29/18723 | 7.22e-04 | 9.44e-03 | 12 |
GO:00365031 | Colorectum | SER | ERAD pathway | 28/2897 | 107/18723 | 2.92e-03 | 2.59e-02 | 28 |
GO:0032527 | Colorectum | SER | protein exit from endoplasmic reticulum | 15/2897 | 48/18723 | 4.60e-03 | 3.64e-02 | 15 |
GO:00104982 | Colorectum | MSS | proteasomal protein catabolic process | 157/3467 | 490/18723 | 2.39e-13 | 5.25e-11 | 157 |
GO:00431612 | Colorectum | MSS | proteasome-mediated ubiquitin-dependent protein catabolic process | 127/3467 | 412/18723 | 7.70e-10 | 6.32e-08 | 127 |
GO:00349762 | Colorectum | MSS | response to endoplasmic reticulum stress | 81/3467 | 256/18723 | 2.65e-07 | 1.10e-05 | 81 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TMEM129 | SNV | Missense_Mutation | c.584N>A | p.Arg195Gln | p.R195Q | A0AVI4 | protein_coding | tolerated(0.54) | benign(0.001) | TCGA-EA-A5O9-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
TMEM129 | SNV | Missense_Mutation | rs11945830 | c.301N>A | p.Val101Met | p.V101M | A0AVI4 | protein_coding | deleterious(0.03) | benign(0.354) | TCGA-AD-6895-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
TMEM129 | SNV | Missense_Mutation | c.944N>A | p.Arg315His | p.R315H | A0AVI4 | protein_coding | tolerated(0.05) | possibly_damaging(0.511) | TCGA-CM-6674-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
TMEM129 | deletion | Frame_Shift_Del | c.368delN | p.Pro123HisfsTer42 | p.P123Hfs*42 | A0AVI4 | protein_coding | TCGA-G4-6302-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |||
TMEM129 | SNV | Missense_Mutation | novel | c.266C>A | p.Ala89Asp | p.A89D | A0AVI4 | protein_coding | tolerated(0.21) | benign(0.327) | TCGA-A5-A2K3-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | SD |
TMEM129 | SNV | Missense_Mutation | rs781162476 | c.541G>A | p.Val181Met | p.V181M | A0AVI4 | protein_coding | tolerated(0.17) | benign(0.172) | TCGA-AX-A1C4-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TMEM129 | SNV | Missense_Mutation | novel | c.1055G>A | p.Arg352His | p.R352H | A0AVI4 | protein_coding | deleterious(0.04) | possibly_damaging(0.616) | TCGA-B5-A3FC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TMEM129 | SNV | Missense_Mutation | novel | c.544N>A | p.Ala182Thr | p.A182T | A0AVI4 | protein_coding | deleterious(0.03) | probably_damaging(0.989) | TCGA-DI-A1BU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | paclitaxel | SD |
TMEM129 | SNV | Missense_Mutation | novel | c.544N>A | p.Ala182Thr | p.A182T | A0AVI4 | protein_coding | deleterious(0.03) | probably_damaging(0.989) | TCGA-EO-A22S-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TMEM129 | SNV | Missense_Mutation | c.944G>A | p.Arg315His | p.R315H | A0AVI4 | protein_coding | tolerated(0.05) | possibly_damaging(0.511) | TCGA-EO-A22U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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