Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

Home

Download

Statistics

Help

Contact

	Gene summary
	Malignant transformation analysis
	Malignant transformation related pathway analysis
	Cell-cell communication analysis
	Single-cell gene regulatory network inference analysis
	Somatic mutation of malignant transformation related genes
	Related drugs of malignant transformation related genes

Gene: TMEM117

Gene summary for TMEM117

Gene summary.

Gene information	Species	Human
	Gene symbol	TMEM117
	Gene ID	84216
	Gene name	transmembrane protein 117
	Gene Alias	TMEM117
	Cytomap	12q12
	Gene Type	protein-coding
	GO ID	GO:0006915
	UniProtAcc	F8VS00

Top

Malignant transformation analysis

Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells

Malignant transformation involving gene list.

Entrez ID	Symbol	Replicates	Species	Organ	Tissue	Adj P-value	Log2FC	Malignancy
84216	TMEM117	CCI_1	Human	Cervix	CC	2.49e-32	1.91e+00	0.528
84216	TMEM117	CCI_2	Human	Cervix	CC	2.81e-07	6.71e-01	0.5249
84216	TMEM117	CCI_3	Human	Cervix	CC	1.10e-19	1.26e+00	0.516
84216	TMEM117	CCII_1	Human	Cervix	CC	9.07e-03	2.02e-01	0.3249
84216	TMEM117	HTA11_3410_2000001011	Human	Colorectum	AD	6.63e-31	-8.07e-01	0.0155
84216	TMEM117	HTA11_2951_2000001011	Human	Colorectum	AD	1.15e-02	-6.88e-01	0.0216
84216	TMEM117	HTA11_78_2000001011	Human	Colorectum	AD	1.71e-06	-4.31e-01	-0.1088
84216	TMEM117	HTA11_3361_2000001011	Human	Colorectum	AD	3.82e-10	-6.30e-01	-0.1207
84216	TMEM117	HTA11_5216_2000001011	Human	Colorectum	SER	1.42e-04	-5.15e-01	-0.1462
84216	TMEM117	HTA11_546_2000001011	Human	Colorectum	AD	1.88e-04	-5.59e-01	-0.0842
84216	TMEM117	HTA11_7862_2000001011	Human	Colorectum	AD	2.48e-03	-6.57e-01	-0.0179
84216	TMEM117	HTA11_866_3004761011	Human	Colorectum	AD	7.68e-32	-8.60e-01	0.096
84216	TMEM117	HTA11_9408_2000001011	Human	Colorectum	AD	4.20e-02	-6.73e-01	0.0451
84216	TMEM117	HTA11_8622_2000001021	Human	Colorectum	SER	2.78e-05	-7.31e-01	0.0528
84216	TMEM117	HTA11_7663_2000001011	Human	Colorectum	SER	5.37e-04	-6.46e-01	0.0131
84216	TMEM117	HTA11_10623_2000001011	Human	Colorectum	AD	2.18e-03	-5.92e-01	-0.0177
84216	TMEM117	HTA11_6801_2000001011	Human	Colorectum	SER	4.56e-02	-6.90e-01	0.0171
84216	TMEM117	HTA11_10711_2000001011	Human	Colorectum	AD	7.38e-07	-5.93e-01	0.0338
84216	TMEM117	HTA11_7696_3000711011	Human	Colorectum	AD	3.24e-13	-5.48e-01	0.0674
84216	TMEM117	HTA11_7469_2000001011	Human	Colorectum	AD	9.46e-03	-8.78e-01	-0.0124

Page: 1 2 3 4 5 6 7

Transcriptomic changes along malignancy continuum.

Tissue	Expression Dynamics	Abbreviation
Cervix		CC: Cervix cancer
		HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions
		N_HPV: HPV-infected normal cervix
Colorectum (GSE201348)		FAP: Familial adenomatous polyposis
		CRC: Colorectal cancer
Colorectum (HTA11)		AD: Adenomas
		SER: Sessile serrated lesions
		MSI-H: Microsatellite-high colorectal cancer
		MSS: Microsatellite stable colorectal cancer
Endometrium		AEH: Atypical endometrial hyperplasia
		EEC: Endometrioid Cancer
Esophagus		ESCC: Esophageal squamous cell carcinoma
		HGIN: High-grade intraepithelial neoplasias
		LGIN: Low-grade intraepithelial neoplasias
Skin		AK: Actinic keratosis
		cSCC: Cutaneous squamous cell carcinoma
		SCCIS:squamous cell carcinoma in situ
Thyroid		ATC: Anaplastic thyroid cancer
		HT: Hashimoto's thyroiditis
		PTC: Papillary thyroid cancer

∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

Top

Malignant transformation related pathway analysis

Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer

Figure of enriched GO biological processes.

Tissue	Disease Stage	Enriched GO biological Processes
Colorectum	AD
Colorectum	SER
Colorectum	MSS
Colorectum	MSI-H
Colorectum	FAP

∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).

Page: 1 2 3 4 5 6 7 8 9

Enriched GO biological processes.

GO ID	Tissue	Disease Stage	Description	Gene Ratio	Bg Ratio	pvalue	p.adjust	Count
GO:009719310	Cervix	CC	intrinsic apoptotic signaling pathway	85/2311	288/18723	4.56e-15	6.46e-12	85
GO:003497610	Cervix	CC	response to endoplasmic reticulum stress	57/2311	256/18723	5.81e-06	1.42e-04	57
GO:00700599	Cervix	CC	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	21/2311	63/18723	1.18e-05	2.51e-04	21
GO:0097193	Colorectum	AD	intrinsic apoptotic signaling pathway	108/3918	288/18723	6.25e-11	6.41e-09	108
GO:0034976	Colorectum	AD	response to endoplasmic reticulum stress	90/3918	256/18723	8.48e-08	4.28e-06	90
GO:0070059	Colorectum	AD	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	29/3918	63/18723	7.03e-06	1.73e-04	29
GO:00971931	Colorectum	SER	intrinsic apoptotic signaling pathway	87/2897	288/18723	1.67e-10	2.32e-08	87
GO:00349761	Colorectum	SER	response to endoplasmic reticulum stress	74/2897	256/18723	3.01e-08	2.05e-06	74
GO:00700591	Colorectum	SER	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	25/2897	63/18723	2.92e-06	1.18e-04	25
GO:00971932	Colorectum	MSS	intrinsic apoptotic signaling pathway	102/3467	288/18723	6.06e-12	9.82e-10	102
GO:00349762	Colorectum	MSS	response to endoplasmic reticulum stress	81/3467	256/18723	2.65e-07	1.10e-05	81
GO:00700592	Colorectum	MSS	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	27/3467	63/18723	6.93e-06	1.79e-04	27
GO:00349764	Colorectum	FAP	response to endoplasmic reticulum stress	61/2622	256/18723	1.58e-05	4.10e-04	61
GO:00971934	Colorectum	FAP	intrinsic apoptotic signaling pathway	66/2622	288/18723	2.76e-05	6.33e-04	66
GO:00700593	Colorectum	FAP	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	18/2622	63/18723	1.95e-03	1.65e-02	18
GO:00971935	Colorectum	CRC	intrinsic apoptotic signaling pathway	57/2078	288/18723	9.77e-06	3.31e-04	57
GO:009719316	Endometrium	AEH	intrinsic apoptotic signaling pathway	75/2100	288/18723	1.46e-12	2.83e-10	75
GO:003497616	Endometrium	AEH	response to endoplasmic reticulum stress	62/2100	256/18723	2.88e-09	2.13e-07	62
GO:007005910	Endometrium	AEH	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	18/2100	63/18723	1.32e-04	1.80e-03	18
GO:009719317	Endometrium	EEC	intrinsic apoptotic signaling pathway	80/2168	288/18723	3.35e-14	9.13e-12	80

Page: 1 2

Enriched KEGG pathways.

Pathway ID

Tissue

Disease Stage

Description

Gene Ratio

Bg Ratio

pvalue

p.adjust

qvalue

Count

Page: 1

Top

Cell-cell communication analysis

Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states

Ligand

Receptor

LRpair

Pathway

Tissue

Disease Stage

Page: 1

Top

Single-cell gene regulatory network inference analysis

Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states

Cell Type

Tissue

Disease Stage

Target Gene

RSS

Regulon Activity

∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.

Page: 1

Top

Somatic mutation of malignant transformation related genes

Annotation of somatic variants for genes involved in malignant transformation

Hugo Symbol

Variant Class

Variant Classification

dbSNP RS

HGVSc

HGVSp

HGVSp Short

SWISSPROT

BIOTYPE

SIFT

PolyPhen

Tumor Sample Barcode

Tissue

Histology

Sex

Age

Stage

Therapy Types

Drugs

Outcome

TMEM117

SNV

Missense_Mutation

rs769011235

c.92C>T

p.Ala31Val

p.A31V

Q9H0C3

protein_coding

tolerated(0.14)

probably_damaging(0.987)

TCGA-A7-A26H-01

Breast

breast invasive carcinoma

Female

>=65

I/II

Hormone Therapy

anastrozole

TMEM117

SNV

Missense_Mutation

c.256C>A

p.Leu86Met

p.L86M

Q9H0C3

protein_coding

deleterious(0.04)

possibly_damaging(0.571)

TCGA-AO-A0JC-01

Breast

breast invasive carcinoma

Female

<65

I/II

Chemotherapy

fluorouracil

TMEM117

SNV

Missense_Mutation

c.719C>T

p.Ala240Val

p.A240V

Q9H0C3

protein_coding

deleterious(0)

benign(0.084)

TCGA-C8-A12V-01

Breast

breast invasive carcinoma

Female

<65

I/II

Unknown

TMEM117

SNV

Missense_Mutation

rs772555669

c.1429N>A

p.Val477Ile

p.V477I

Q9H0C3

protein_coding

tolerated_low_confidence(0.16)

benign(0.003)

TCGA-D8-A1XK-01

Breast

breast invasive carcinoma

Female

<65

I/II

Chemotherapy

doxorubicine+cyclophosphamide

TMEM117

deletion

In_Frame_Del

c.371_397delNNNNNNNNNNNNNNNNNNNNNNNNNNN

p.Ile125_Asp133del

p.I125_D133del

Q9H0C3

protein_coding

TCGA-A8-A08L-01

Breast

breast invasive carcinoma

Female

>=65

III/IV

Unknown

TMEM117

insertion

In_Frame_Ins

novel

c.1425_1426insGTTTATAAA

p.Glu475_Ile476insValTyrLys

p.E475_I476insVYK

Q9H0C3

protein_coding

TCGA-AR-A0U0-01

Breast

breast invasive carcinoma

Female

>=65

I/II

Unknown

TMEM117

SNV

Missense_Mutation

novel

c.617N>C

p.Leu206Pro

p.L206P

Q9H0C3

protein_coding

deleterious(0.02)

probably_damaging(0.98)

TCGA-2W-A8YY-01

Cervix

cervical & endocervical cancer

Female

<65

I/II

Chemotherapy

cisplatin

TMEM117

SNV

Missense_Mutation

novel

c.573C>G

p.Phe191Leu

p.F191L

Q9H0C3

protein_coding

tolerated(0.6)

benign(0.006)

TCGA-JW-A5VL-01

Cervix

cervical & endocervical cancer

Female

<65

I/II

Unknown

TMEM117

SNV

Missense_Mutation

c.700A>G

p.Ser234Gly

p.S234G

Q9H0C3

protein_coding

deleterious(0.01)

probably_damaging(0.953)

TCGA-JX-A3PZ-01

Cervix

cervical & endocervical cancer

Female

<65

I/II

Unknown

TMEM117

SNV

Missense_Mutation

rs145821678

c.443N>A

p.Arg148Gln

p.R148Q

Q9H0C3

protein_coding

tolerated(0.11)

probably_damaging(0.979)

TCGA-AA-3510-01

Colorectum

colon adenocarcinoma

Male

>=65

I/II

Unknown

Page: 1 2 3 4 5 6 7 8

Top

Related drugs of malignant transformation related genes

Identification of chemicals and drugs interact with genes involved in malignant transfromation

(DGIdb 4.0)

Entrez ID

Symbol

Category

Interaction Types

Drug Claim Name

Drug Name

PMIDs

Page: 1