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Gene: TMEM110 |
Gene summary for TMEM110 |
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Gene information | Species | Human | Gene symbol | TMEM110 | Gene ID | 375346 |
Gene name | STIM activating enhancer | |
Gene Alias | TMEM110 | |
Cytomap | 3p21.1 | |
Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | Q86TL2 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
375346 | TMEM110 | HCC1_Meng | Human | Liver | HCC | 8.46e-19 | 2.45e-02 | 0.0246 |
375346 | TMEM110 | HCC1 | Human | Liver | HCC | 1.33e-05 | 1.51e+00 | 0.5336 |
375346 | TMEM110 | HCC2 | Human | Liver | HCC | 3.10e-11 | 2.22e+00 | 0.5341 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TMEM110 | SNV | Missense_Mutation | rs775254081 | c.412C>T | p.Arg138Cys | p.R138C | Q86TL2 | protein_coding | tolerated(0.17) | possibly_damaging(0.873) | TCGA-CM-6674-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
TMEM110 | SNV | Missense_Mutation | rs549819429 | c.880N>A | p.Val294Ile | p.V294I | Q86TL2 | protein_coding | deleterious_low_confidence(0.03) | probably_damaging(0.959) | TCGA-F5-6810-01 | Colorectum | rectum adenocarcinoma | Unknown | Unknown | I/II | Unknown | Unknown | Unknown |
TMEM110 | SNV | Missense_Mutation | novel | c.526N>T | p.Leu176Phe | p.L176F | Q86TL2 | protein_coding | tolerated(0.05) | benign(0.015) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TMEM110 | SNV | Missense_Mutation | rs779411931 | c.370N>A | p.Ala124Thr | p.A124T | Q86TL2 | protein_coding | tolerated(0.27) | benign(0.031) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TMEM110 | SNV | Missense_Mutation | novel | c.740N>T | p.Ala247Val | p.A247V | Q86TL2 | protein_coding | tolerated(0.17) | benign(0.196) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
TMEM110 | SNV | Missense_Mutation | rs775254081 | c.412N>T | p.Arg138Cys | p.R138C | Q86TL2 | protein_coding | tolerated(0.17) | possibly_damaging(0.873) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
TMEM110 | SNV | Missense_Mutation | novel | c.193N>T | p.Arg65Cys | p.R65C | Q86TL2 | protein_coding | deleterious(0.02) | probably_damaging(1) | TCGA-AP-A051-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TMEM110 | SNV | Missense_Mutation | novel | c.650T>C | p.Leu217Pro | p.L217P | Q86TL2 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-AP-A1DK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TMEM110 | SNV | Missense_Mutation | rs377432257 | c.782N>T | p.Ala261Val | p.A261V | Q86TL2 | protein_coding | tolerated(0.09) | probably_damaging(0.98) | TCGA-AP-A1DV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TMEM110 | SNV | Missense_Mutation | c.583G>A | p.Ala195Thr | p.A195T | Q86TL2 | protein_coding | tolerated(0.16) | possibly_damaging(0.511) | TCGA-AX-A0J1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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