Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

Home

Download

Statistics

Help

Contact

	Gene summary
	Malignant transformation analysis
	Malignant transformation related pathway analysis
	Cell-cell communication analysis
	Single-cell gene regulatory network inference analysis
	Somatic mutation of malignant transformation related genes
	Related drugs of malignant transformation related genes

Gene: TMEM102

Gene summary for TMEM102

Gene summary.

Gene information	Species	Human
	Gene symbol	TMEM102
	Gene ID	284114
	Gene name	transmembrane protein 102
	Gene Alias	CBAP
	Cytomap	17p13.1
	Gene Type	protein-coding
	GO ID	GO:0001932
	UniProtAcc	Q8N9M5

Top

Malignant transformation analysis

Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells

Malignant transformation involving gene list.

Entrez ID	Symbol	Replicates	Species	Organ	Tissue	Adj P-value	Log2FC	Malignancy
284114	TMEM102	C21	Human	Oral cavity	OSCC	4.93e-03	2.18e-01	0.2678
284114	TMEM102	C30	Human	Oral cavity	OSCC	7.09e-16	6.17e-01	0.3055
284114	TMEM102	C51	Human	Oral cavity	OSCC	2.87e-04	3.17e-01	0.2674
284114	TMEM102	C08	Human	Oral cavity	OSCC	4.86e-06	2.05e-01	0.1919
284114	TMEM102	SYSMH1	Human	Oral cavity	OSCC	3.93e-05	2.19e-01	0.1127
284114	TMEM102	SYSMH3	Human	Oral cavity	OSCC	1.24e-28	7.17e-01	0.2442

Page: 1

Transcriptomic changes along malignancy continuum.

Tissue	Expression Dynamics	Abbreviation
Oral Cavity		EOLP: Erosive Oral lichen planus
		LP: leukoplakia
		NEOLP: Non-erosive oral lichen planus
		OSCC: Oral squamous cell carcinoma

∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

Top

Malignant transformation related pathway analysis

Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer

Figure of enriched GO biological processes.

Tissue	Disease Stage	Enriched GO biological Processes
Colorectum	AD
Colorectum	SER
Colorectum	MSS
Colorectum	MSI-H
Colorectum	FAP

∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).

Page: 1 2 3 4 5 6 7 8 9

Enriched GO biological processes.

GO ID	Tissue	Disease Stage	Description	Gene Ratio	Bg Ratio	pvalue	p.adjust	Count
GO:000683918	Oral cavity	OSCC	mitochondrial transport	162/7305	254/18723	8.96e-16	6.52e-14	162
GO:000700610	Oral cavity	OSCC	mitochondrial membrane organization	85/7305	116/18723	6.29e-14	3.40e-12	85
GO:000863718	Oral cavity	OSCC	apoptotic mitochondrial changes	78/7305	107/18723	1.06e-12	4.78e-11	78
GO:001082117	Oral cavity	OSCC	regulation of mitochondrion organization	97/7305	144/18723	4.78e-12	1.83e-10	97
GO:00905598	Oral cavity	OSCC	regulation of membrane permeability	54/7305	78/18723	6.05e-08	1.09e-06	54
GO:004578520	Oral cavity	OSCC	positive regulation of cell adhesion	225/7305	437/18723	6.06e-08	1.09e-06	225
GO:00469028	Oral cavity	OSCC	regulation of mitochondrial membrane permeability	45/7305	63/18723	1.80e-07	2.92e-06	45
GO:000268714	Oral cavity	OSCC	positive regulation of leukocyte migration	78/7305	135/18723	7.43e-06	8.08e-05	78
GO:00357947	Oral cavity	OSCC	positive regulation of mitochondrial membrane permeability	31/7305	43/18723	1.10e-05	1.14e-04	31
GO:00973459	Oral cavity	OSCC	mitochondrial outer membrane permeabilization	24/7305	32/18723	3.83e-05	3.37e-04	24
GO:19026868	Oral cavity	OSCC	mitochondrial outer membrane permeabilization involved in programmed cell death	28/7305	40/18723	7.00e-05	5.60e-04	28
GO:19057107	Oral cavity	OSCC	positive regulation of membrane permeability	32/7305	48/18723	9.60e-05	7.25e-04	32
GO:000268510	Oral cavity	OSCC	regulation of leukocyte migration	108/7305	210/18723	1.63e-04	1.13e-03	108
GO:00321037	Oral cavity	OSCC	positive regulation of response to external stimulus	203/7305	427/18723	1.79e-04	1.22e-03	203
GO:19021107	Oral cavity	OSCC	positive regulation of mitochondrial membrane permeability involved in apoptotic process	26/7305	38/18723	2.29e-04	1.49e-03	26
GO:00509216	Oral cavity	OSCC	positive regulation of chemotaxis	76/7305	141/18723	2.30e-04	1.49e-03	76
GO:00182123	Oral cavity	OSCC	peptidyl-tyrosine modification	180/7305	378/18723	3.63e-04	2.22e-03	180
GO:005090010	Oral cavity	OSCC	leukocyte migration	176/7305	369/18723	3.80e-04	2.31e-03	176
GO:00026908	Oral cavity	OSCC	positive regulation of leukocyte chemotaxis	53/7305	94/18723	4.71e-04	2.79e-03	53
GO:19021085	Oral cavity	OSCC	regulation of mitochondrial membrane permeability involved in apoptotic process	29/7305	45/18723	4.85e-04	2.86e-03	29

Page: 1 2

Enriched KEGG pathways.

Pathway ID

Tissue

Disease Stage

Description

Gene Ratio

Bg Ratio

pvalue

p.adjust

qvalue

Count

Page: 1

Top

Cell-cell communication analysis

Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states

Ligand

Receptor

LRpair

Pathway

Tissue

Disease Stage

Page: 1

Top

Single-cell gene regulatory network inference analysis

Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states

Cell Type

Tissue

Disease Stage

Target Gene

RSS

Regulon Activity

∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.

Page: 1

Top

Somatic mutation of malignant transformation related genes

Annotation of somatic variants for genes involved in malignant transformation

Hugo Symbol

Variant Class

Variant Classification

dbSNP RS

HGVSc

HGVSp

HGVSp Short

SWISSPROT

BIOTYPE

SIFT

PolyPhen

Tumor Sample Barcode

Tissue

Histology

Sex

Age

Stage

Therapy Types

Drugs

Outcome

TMEM102

SNV

Missense_Mutation

c.68T>A

p.Leu23His

p.L23H

Q8N9M5

protein_coding

deleterious(0)

probably_damaging(0.994)

TCGA-Q1-A6DT-01

Cervix

cervical & endocervical cancer

Female

<65

I/II

Unknown

TMEM102

SNV

Missense_Mutation

rs781113230

c.397C>G

p.Leu133Val

p.L133V

Q8N9M5

protein_coding

tolerated(0.32)

benign(0.037)

TCGA-A5-A7WJ-01

Endometrium

uterine corpus endometrioid carcinoma

Female

<65

I/II

Unknown

TMEM102

SNV

Missense_Mutation

novel

c.316N>A

p.Leu106Met

p.L106M

Q8N9M5

protein_coding

deleterious(0.02)

probably_damaging(0.998)

TCGA-AP-A051-01

Endometrium

uterine corpus endometrioid carcinoma

Female

>=65

I/II

Unknown

TMEM102

SNV

Missense_Mutation

novel

c.860C>T

p.Ala287Val

p.A287V

Q8N9M5

protein_coding

tolerated(0.18)

possibly_damaging(0.824)

TCGA-AP-A0LM-01

Endometrium

uterine corpus endometrioid carcinoma

Female

<65

III/IV

Chemotherapy

cisplatin

TMEM102

SNV

Missense_Mutation

rs759373786

c.61N>T

p.Arg21Trp

p.R21W

Q8N9M5

protein_coding

deleterious(0)

benign(0.279)

TCGA-BK-A13B-01

Endometrium

uterine corpus endometrioid carcinoma

Female

<65

I/II

Unknown

TMEM102

SNV

Missense_Mutation

rs757787595

c.352N>A

p.Gly118Ser

p.G118S

Q8N9M5

protein_coding

tolerated(0.13)

benign(0.017)

TCGA-EO-A22R-01

Endometrium

uterine corpus endometrioid carcinoma

Female

<65

I/II

Unknown

TMEM102

SNV

Missense_Mutation

novel

c.502N>T

p.Pro168Ser

p.P168S

Q8N9M5

protein_coding

tolerated_low_confidence(0.13)

benign(0.041)

TCGA-FI-A2D0-01

Endometrium

uterine corpus endometrioid carcinoma

Female

<65

I/II

Unknown

TMEM102

SNV

Missense_Mutation

rs746348316

c.787N>C

p.Ser263Pro

p.S263P

Q8N9M5

protein_coding

tolerated(1)

benign(0)

TCGA-FI-A2D5-01

Endometrium

uterine corpus endometrioid carcinoma

Female

<65

III/IV

Chemotherapy

carboplatinum

TMEM102

insertion

Frame_Shift_Ins

novel

c.16_17insG

p.Ser8GlufsTer45

p.S8Efs*45

Q8N9M5

protein_coding

TCGA-DF-A2KY-01

Endometrium

uterine corpus endometrioid carcinoma

Female

<65

III/IV

Chemotherapy

carboplatin

TMEM102

SNV

Missense_Mutation

c.188N>T

p.Ala63Val

p.A63V

Q8N9M5

protein_coding

deleterious(0)

probably_damaging(0.984)

TCGA-DD-A1EE-01

Liver

liver hepatocellular carcinoma

Male

>=65

III/IV

Unknown

Page: 1 2 3

Top

Related drugs of malignant transformation related genes

Identification of chemicals and drugs interact with genes involved in malignant transfromation

(DGIdb 4.0)

Entrez ID

Symbol

Category

Interaction Types

Drug Claim Name

Drug Name

PMIDs

Page: 1