Tissue | Expression Dynamics | Abbreviation |
Colorectum (GSE201348) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Becker/TMCC3_pca_on_diff_genes.png) | FAP: Familial adenomatous polyposis |
CRC: Colorectal cancer |
Colorectum (HTA11) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Chen/TMCC3_pca_on_diff_genes.png) | AD: Adenomas |
SER: Sessile serrated lesions |
MSI-H: Microsatellite-high colorectal cancer |
MSS: Microsatellite stable colorectal cancer |
Esophagus | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Esophagus/TMCC3_pca_on_diff_genes.png) | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
GC | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/GC/TMCC3_pca_on_diff_genes.png) | CAG: Chronic atrophic gastritis |
CAG with IM: Chronic atrophic gastritis with intestinal metaplasia |
CSG: Chronic superficial gastritis |
GC: Gastric cancer |
SIM: Severe intestinal metaplasia |
WIM: Wild intestinal metaplasia |
Thyroid | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Thyroid/TMCC3_pca_on_diff_genes.png) | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis |
PTC: Papillary thyroid cancer |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TMCC3 | SNV | Missense_Mutation | | c.1379N>C | p.Cys460Ser | p.C460S | Q9ULS5 | protein_coding | deleterious(0) | possibly_damaging(0.82) | TCGA-A2-A0EV-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TMCC3 | SNV | Missense_Mutation | rs371831752 | c.446N>G | p.Ser149Cys | p.S149C | Q9ULS5 | protein_coding | deleterious(0.04) | possibly_damaging(0.661) | TCGA-A8-A094-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TMCC3 | SNV | Missense_Mutation | | c.1323N>C | p.Lys441Asn | p.K441N | Q9ULS5 | protein_coding | deleterious(0) | possibly_damaging(0.836) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
TMCC3 | SNV | Missense_Mutation | novel | c.483N>T | p.Lys161Asn | p.K161N | Q9ULS5 | protein_coding | deleterious(0) | possibly_damaging(0.463) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TMCC3 | SNV | Missense_Mutation | novel | c.473A>G | p.Asp158Gly | p.D158G | Q9ULS5 | protein_coding | tolerated(0.11) | possibly_damaging(0.609) | TCGA-AN-A0AK-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TMCC3 | SNV | Missense_Mutation | novel | c.424N>C | p.Glu142Gln | p.E142Q | Q9ULS5 | protein_coding | deleterious(0) | possibly_damaging(0.685) | TCGA-BH-A0B6-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TMCC3 | SNV | Missense_Mutation | | c.1417N>G | p.Met473Val | p.M473V | Q9ULS5 | protein_coding | tolerated(1) | benign(0) | TCGA-BH-A18G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TMCC3 | SNV | Missense_Mutation | | c.982G>C | p.Glu328Gln | p.E328Q | Q9ULS5 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-C8-A26W-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | CR |
TMCC3 | SNV | Missense_Mutation | | c.1092N>C | p.Lys364Asn | p.K364N | Q9ULS5 | protein_coding | deleterious(0) | probably_damaging(0.984) | TCGA-D8-A1JN-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Hormone Therapy | anastrozolum | SD |
TMCC3 | insertion | Nonsense_Mutation | novel | c.1240_1241insCCACAGCAGTCAGTCGTGTATGACCCTGTAACGTGGAAA | p.Cys414delinsSerThrAlaValSerArgValTerProCysAsnValGluSer | p.C414delinsSTAVSRV*PCNVES | Q9ULS5 | protein_coding | | | TCGA-AN-A0FT-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |