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Gene: TMC7 |
Gene summary for TMC7 |
Gene summary. |
Gene information | Species | Human | Gene symbol | TMC7 | Gene ID | 79905 |
Gene name | transmembrane channel like 7 | |
Gene Alias | TMC7 | |
Cytomap | 16p12.3 | |
Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | Q7Z402 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
79905 | TMC7 | HCC1_Meng | Human | Liver | HCC | 3.52e-04 | 1.17e-02 | 0.0246 |
79905 | TMC7 | HCC2_Meng | Human | Liver | HCC | 4.57e-18 | 1.91e-01 | 0.0107 |
79905 | TMC7 | HCC1 | Human | Liver | HCC | 3.20e-13 | 1.32e+00 | 0.5336 |
79905 | TMC7 | HCC2 | Human | Liver | HCC | 1.26e-24 | 1.65e+00 | 0.5341 |
79905 | TMC7 | HCC5 | Human | Liver | HCC | 1.51e-13 | 1.75e+00 | 0.4932 |
79905 | TMC7 | S027 | Human | Liver | HCC | 1.22e-04 | 3.51e-01 | 0.2446 |
79905 | TMC7 | S028 | Human | Liver | HCC | 7.75e-07 | 3.13e-01 | 0.2503 |
79905 | TMC7 | S029 | Human | Liver | HCC | 1.18e-04 | 2.13e-01 | 0.2581 |
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Transcriptomic changes along malignancy continuum. |
Tissue | Expression Dynamics | Abbreviation |
Liver | HCC: Hepatocellular carcinoma | |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TMC7 | SNV | Missense_Mutation | novel | c.1105N>A | p.Val369Ile | p.V369I | protein_coding | tolerated(0.07) | possibly_damaging(0.668) | TCGA-A1-A0SP-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | SD | ||
TMC7 | SNV | Missense_Mutation | c.1993N>C | p.Glu665Gln | p.E665Q | protein_coding | tolerated(0.28) | benign(0.392) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | ||
TMC7 | SNV | Missense_Mutation | rs200072588 | c.118C>T | p.Leu40Phe | p.L40F | protein_coding | deleterious(0.04) | benign(0.328) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
TMC7 | SNV | Missense_Mutation | novel | c.272G>A | p.Arg91Gln | p.R91Q | protein_coding | deleterious(0.03) | probably_damaging(0.981) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
TMC7 | SNV | Missense_Mutation | novel | c.1222T>C | p.Tyr408His | p.Y408H | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
TMC7 | SNV | Missense_Mutation | c.155N>A | p.Arg52Lys | p.R52K | protein_coding | tolerated(0.06) | benign(0.05) | TCGA-AR-A1AK-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | anastrozole | SD | ||
TMC7 | SNV | Missense_Mutation | c.2060N>A | p.Gly687Glu | p.G687E | protein_coding | deleterious(0.05) | possibly_damaging(0.561) | TCGA-E9-A1RA-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | ||
TMC7 | insertion | Frame_Shift_Ins | novel | c.1641_1642insCAATTAGCCAAGCATGCACATGTAGTCTCAGCCACTTG | p.Val548GlnfsTer36 | p.V548Qfs*36 | protein_coding | TCGA-A2-A04Q-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD | |||
TMC7 | insertion | Nonsense_Mutation | novel | c.841_842insACATGCACCTCTATGCCTAGCTAATTTT | p.Leu281HisfsTer7 | p.L281Hfs*7 | protein_coding | TCGA-A8-A06U-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |||
TMC7 | insertion | Frame_Shift_Ins | novel | c.460_460+1insCCGCACCGGGCCAGGAA | p.Gly154AlafsTer20 | p.G154Afs*20 | protein_coding | TCGA-BH-A0BD-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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