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Gene: TMC1 |
Gene summary for TMC1 |
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Gene information | Species | Human | Gene symbol | TMC1 | Gene ID | 117531 |
Gene name | transmembrane channel like 1 | |
Gene Alias | DFNA36 | |
Cytomap | 9q21.13 | |
Gene Type | protein-coding | GO ID | GO:0002064 | UniProtAcc | Q8TDI8 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
117531 | TMC1 | HTA11_2487_2000001011 | Human | Colorectum | SER | 2.89e-04 | 1.68e-01 | -0.1808 |
117531 | TMC1 | HTA11_1938_2000001011 | Human | Colorectum | AD | 2.86e-06 | 2.17e-01 | -0.0811 |
117531 | TMC1 | HTA11_347_2000001011 | Human | Colorectum | AD | 3.72e-05 | 1.38e-01 | -0.1954 |
117531 | TMC1 | HTA11_411_2000001011 | Human | Colorectum | SER | 4.01e-04 | 2.91e-01 | -0.2602 |
117531 | TMC1 | HTA11_3361_2000001011 | Human | Colorectum | AD | 5.46e-03 | 1.42e-01 | -0.1207 |
117531 | TMC1 | HTA11_83_2000001011 | Human | Colorectum | SER | 3.64e-05 | 2.15e-01 | -0.1526 |
117531 | TMC1 | HTA11_696_2000001011 | Human | Colorectum | AD | 7.82e-13 | 2.51e-01 | -0.1464 |
117531 | TMC1 | HTA11_866_2000001011 | Human | Colorectum | AD | 3.74e-03 | 1.32e-01 | -0.1001 |
117531 | TMC1 | HTA11_1391_2000001011 | Human | Colorectum | AD | 1.88e-04 | 1.40e-01 | -0.059 |
117531 | TMC1 | HTA11_2992_2000001011 | Human | Colorectum | SER | 1.94e-06 | 2.84e-01 | -0.1706 |
117531 | TMC1 | HTA11_5212_2000001011 | Human | Colorectum | AD | 2.28e-02 | 2.34e-01 | -0.2061 |
117531 | TMC1 | HTA11_5216_2000001011 | Human | Colorectum | SER | 2.49e-08 | 4.12e-01 | -0.1462 |
117531 | TMC1 | HTA11_546_2000001011 | Human | Colorectum | AD | 4.83e-05 | 1.96e-01 | -0.0842 |
117531 | TMC1 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 3.85e-03 | 8.65e-02 | 0.294 |
117531 | TMC1 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 3.26e-04 | 1.54e-01 | 0.281 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0002064 | Colorectum | AD | epithelial cell development | 89/3918 | 220/18723 | 2.98e-11 | 3.52e-09 | 89 |
GO:0035315 | Colorectum | AD | hair cell differentiation | 21/3918 | 47/18723 | 2.14e-04 | 2.82e-03 | 21 |
GO:0060117 | Colorectum | AD | auditory receptor cell development | 12/3918 | 21/18723 | 3.02e-04 | 3.62e-03 | 12 |
GO:0042491 | Colorectum | AD | inner ear auditory receptor cell differentiation | 17/3918 | 38/18723 | 8.26e-04 | 8.13e-03 | 17 |
GO:0042490 | Colorectum | AD | mechanoreceptor differentiation | 24/3918 | 67/18723 | 3.48e-03 | 2.52e-02 | 24 |
GO:0009913 | Colorectum | AD | epidermal cell differentiation | 58/3918 | 202/18723 | 5.16e-03 | 3.42e-02 | 58 |
GO:0008544 | Colorectum | AD | epidermis development | 87/3918 | 324/18723 | 5.99e-03 | 3.76e-02 | 87 |
GO:0060119 | Colorectum | AD | inner ear receptor cell development | 17/3918 | 45/18723 | 7.10e-03 | 4.33e-02 | 17 |
GO:00020641 | Colorectum | SER | epithelial cell development | 64/2897 | 220/18723 | 1.96e-07 | 1.10e-05 | 64 |
GO:00601171 | Colorectum | SER | auditory receptor cell development | 9/2897 | 21/18723 | 2.50e-03 | 2.33e-02 | 9 |
GO:00353151 | Colorectum | SER | hair cell differentiation | 15/2897 | 47/18723 | 3.68e-03 | 3.07e-02 | 15 |
GO:00020642 | Colorectum | MSS | epithelial cell development | 81/3467 | 220/18723 | 1.02e-10 | 1.06e-08 | 81 |
GO:00601172 | Colorectum | MSS | auditory receptor cell development | 12/3467 | 21/18723 | 8.83e-05 | 1.41e-03 | 12 |
GO:00353152 | Colorectum | MSS | hair cell differentiation | 19/3467 | 47/18723 | 3.88e-04 | 4.86e-03 | 19 |
GO:00424911 | Colorectum | MSS | inner ear auditory receptor cell differentiation | 16/3467 | 38/18723 | 6.47e-04 | 7.06e-03 | 16 |
GO:00601191 | Colorectum | MSS | inner ear receptor cell development | 17/3467 | 45/18723 | 1.89e-03 | 1.65e-02 | 17 |
GO:00424901 | Colorectum | MSS | mechanoreceptor differentiation | 22/3467 | 67/18723 | 3.57e-03 | 2.64e-02 | 22 |
GO:00099131 | Colorectum | MSS | epidermal cell differentiation | 52/3467 | 202/18723 | 6.59e-03 | 4.38e-02 | 52 |
GO:0060113 | Colorectum | MSS | inner ear receptor cell differentiation | 20/3467 | 62/18723 | 6.63e-03 | 4.38e-02 | 20 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TMC1 | SNV | Missense_Mutation | novel | c.1987N>T | p.Asp663Tyr | p.D663Y | Q8TDI8 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TMC1 | SNV | Missense_Mutation | c.2251N>A | p.Ala751Thr | p.A751T | Q8TDI8 | protein_coding | tolerated(0.19) | benign(0.227) | TCGA-EW-A1IZ-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | taxotere | SD | |
TMC1 | SNV | Missense_Mutation | c.820N>A | p.Pro274Thr | p.P274T | Q8TDI8 | protein_coding | deleterious(0) | probably_damaging(0.979) | TCGA-C5-A3HL-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Unknown | Unknown | SD | |
TMC1 | SNV | Missense_Mutation | novel | c.1631N>G | p.Phe544Cys | p.F544C | Q8TDI8 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-EA-A3HU-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
TMC1 | SNV | Missense_Mutation | c.340N>A | p.Glu114Lys | p.E114K | Q8TDI8 | protein_coding | tolerated(1) | benign(0.003) | TCGA-EK-A2R8-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
TMC1 | SNV | Missense_Mutation | novel | c.1411N>C | p.Glu471Gln | p.E471Q | Q8TDI8 | protein_coding | tolerated(0.1) | benign(0.119) | TCGA-MY-A5BF-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Chemotherapy | cisplatin | CR |
TMC1 | SNV | Missense_Mutation | novel | c.1844N>G | p.Ala615Gly | p.A615G | Q8TDI8 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-A6-5665-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
TMC1 | SNV | Missense_Mutation | c.1177N>A | p.Phe393Ile | p.F393I | Q8TDI8 | protein_coding | tolerated(0.07) | probably_damaging(0.998) | TCGA-AA-3821-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
TMC1 | SNV | Missense_Mutation | c.299N>T | p.Arg100Ile | p.R100I | Q8TDI8 | protein_coding | deleterious(0) | benign(0.07) | TCGA-AA-3977-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
TMC1 | SNV | Missense_Mutation | novel | c.1089C>A | p.Phe363Leu | p.F363L | Q8TDI8 | protein_coding | tolerated(0.05) | probably_damaging(0.995) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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