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Gene: TM2D2 |
Gene summary for TM2D2 |
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Gene information | Species | Human | Gene symbol | TM2D2 | Gene ID | 83877 |
Gene name | TM2 domain containing 2 | |
Gene Alias | BLP1 | |
Cytomap | 8p11.22 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | Q9BX73 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
83877 | TM2D2 | LZE4T | Human | Esophagus | ESCC | 6.67e-20 | 7.41e-01 | 0.0811 |
83877 | TM2D2 | LZE8T | Human | Esophagus | ESCC | 5.26e-16 | 2.79e-01 | 0.067 |
83877 | TM2D2 | LZE20T | Human | Esophagus | ESCC | 6.70e-21 | 9.15e-01 | 0.0662 |
83877 | TM2D2 | LZE24T | Human | Esophagus | ESCC | 1.13e-33 | 9.61e-01 | 0.0596 |
83877 | TM2D2 | LZE6T | Human | Esophagus | ESCC | 6.79e-04 | 1.47e-01 | 0.0845 |
83877 | TM2D2 | P1T-E | Human | Esophagus | ESCC | 5.89e-08 | 4.78e-01 | 0.0875 |
83877 | TM2D2 | P2T-E | Human | Esophagus | ESCC | 1.23e-28 | 5.67e-01 | 0.1177 |
83877 | TM2D2 | P4T-E | Human | Esophagus | ESCC | 1.41e-51 | 1.44e+00 | 0.1323 |
83877 | TM2D2 | P5T-E | Human | Esophagus | ESCC | 2.15e-15 | 2.37e-01 | 0.1327 |
83877 | TM2D2 | P8T-E | Human | Esophagus | ESCC | 1.87e-27 | 4.61e-01 | 0.0889 |
83877 | TM2D2 | P9T-E | Human | Esophagus | ESCC | 1.35e-15 | 3.68e-01 | 0.1131 |
83877 | TM2D2 | P10T-E | Human | Esophagus | ESCC | 4.03e-33 | 5.74e-01 | 0.116 |
83877 | TM2D2 | P11T-E | Human | Esophagus | ESCC | 1.19e-22 | 9.83e-01 | 0.1426 |
83877 | TM2D2 | P12T-E | Human | Esophagus | ESCC | 2.16e-42 | 7.97e-01 | 0.1122 |
83877 | TM2D2 | P15T-E | Human | Esophagus | ESCC | 7.94e-08 | 9.91e-02 | 0.1149 |
83877 | TM2D2 | P16T-E | Human | Esophagus | ESCC | 2.26e-19 | 2.75e-01 | 0.1153 |
83877 | TM2D2 | P17T-E | Human | Esophagus | ESCC | 2.31e-09 | 3.06e-01 | 0.1278 |
83877 | TM2D2 | P19T-E | Human | Esophagus | ESCC | 1.29e-03 | 6.04e-01 | 0.1662 |
83877 | TM2D2 | P20T-E | Human | Esophagus | ESCC | 9.51e-27 | 4.21e-01 | 0.1124 |
83877 | TM2D2 | P21T-E | Human | Esophagus | ESCC | 2.89e-49 | 8.83e-01 | 0.1617 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TM2D2 | SNV | Missense_Mutation | c.253N>C | p.Asp85His | p.D85H | Q9BX73 | protein_coding | deleterious(0.01) | benign(0.351) | TCGA-AR-A256-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | PD | |
TM2D2 | SNV | Missense_Mutation | novel | c.121N>A | p.Glu41Lys | p.E41K | Q9BX73 | protein_coding | tolerated_low_confidence(0.79) | benign(0.039) | TCGA-HM-A4S6-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Chemotherapy | cisplatin | CR |
TM2D2 | SNV | Missense_Mutation | c.343N>C | p.Glu115Gln | p.E115Q | Q9BX73 | protein_coding | tolerated(0.18) | benign(0.001) | TCGA-AA-3955-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | capecitabine | CR | |
TM2D2 | SNV | Missense_Mutation | novel | c.407N>C | p.Leu136Pro | p.L136P | Q9BX73 | protein_coding | deleterious(0.05) | probably_damaging(0.997) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
TM2D2 | SNV | Missense_Mutation | rs765267190 | c.322N>A | p.Gly108Ser | p.G108S | Q9BX73 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-CK-4951-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
TM2D2 | SNV | Missense_Mutation | c.620G>A | p.Gly207Asp | p.G207D | Q9BX73 | protein_coding | tolerated(0.23) | benign(0.186) | TCGA-D5-6930-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
TM2D2 | SNV | Missense_Mutation | rs763366754 | c.626N>G | p.Asn209Ser | p.N209S | Q9BX73 | protein_coding | tolerated(0.09) | probably_damaging(0.978) | TCGA-A5-A0GG-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TM2D2 | SNV | Missense_Mutation | novel | c.266A>G | p.His89Arg | p.H89R | Q9BX73 | protein_coding | tolerated(0.27) | possibly_damaging(0.502) | TCGA-AP-A1DK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TM2D2 | SNV | Missense_Mutation | c.437N>T | p.Thr146Ile | p.T146I | Q9BX73 | protein_coding | deleterious(0) | probably_damaging(0.986) | TCGA-AX-A0J1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
TM2D2 | SNV | Missense_Mutation | rs199739639 | c.383A>G | p.Glu128Gly | p.E128G | Q9BX73 | protein_coding | deleterious(0) | probably_damaging(0.991) | TCGA-AX-A3FT-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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