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Gene: TIMM9 |
Gene summary for TIMM9 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | TIMM9 | Gene ID | 26520 |
| Gene name | translocase of inner mitochondrial membrane 9 | |
| Gene Alias | TIM9 | |
| Cytomap | 14q23.1 | |
| Gene Type | protein-coding | GO ID | GO:0003008 | UniProtAcc | A0A024R648 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 26520 | TIMM9 | LZE2D | Human | Esophagus | HGIN | 5.38e-04 | 2.22e-01 | 0.0642 |
| 26520 | TIMM9 | LZE2T | Human | Esophagus | ESCC | 4.81e-02 | 6.30e-01 | 0.082 |
| 26520 | TIMM9 | LZE4T | Human | Esophagus | ESCC | 3.72e-06 | 3.89e-01 | 0.0811 |
| 26520 | TIMM9 | LZE8T | Human | Esophagus | ESCC | 7.63e-03 | 4.36e-02 | 0.067 |
| 26520 | TIMM9 | LZE20T | Human | Esophagus | ESCC | 5.63e-05 | 3.22e-01 | 0.0662 |
| 26520 | TIMM9 | LZE24T | Human | Esophagus | ESCC | 4.81e-07 | 2.93e-01 | 0.0596 |
| 26520 | TIMM9 | P2T-E | Human | Esophagus | ESCC | 8.14e-18 | 4.17e-01 | 0.1177 |
| 26520 | TIMM9 | P4T-E | Human | Esophagus | ESCC | 1.10e-21 | 6.99e-01 | 0.1323 |
| 26520 | TIMM9 | P5T-E | Human | Esophagus | ESCC | 5.53e-22 | 6.56e-01 | 0.1327 |
| 26520 | TIMM9 | P8T-E | Human | Esophagus | ESCC | 1.14e-20 | 5.22e-01 | 0.0889 |
| 26520 | TIMM9 | P9T-E | Human | Esophagus | ESCC | 7.09e-16 | 3.19e-01 | 0.1131 |
| 26520 | TIMM9 | P10T-E | Human | Esophagus | ESCC | 1.80e-30 | 7.30e-01 | 0.116 |
| 26520 | TIMM9 | P11T-E | Human | Esophagus | ESCC | 2.66e-12 | 7.11e-01 | 0.1426 |
| 26520 | TIMM9 | P12T-E | Human | Esophagus | ESCC | 1.46e-43 | 8.71e-01 | 0.1122 |
| 26520 | TIMM9 | P15T-E | Human | Esophagus | ESCC | 5.77e-50 | 1.38e+00 | 0.1149 |
| 26520 | TIMM9 | P16T-E | Human | Esophagus | ESCC | 1.51e-27 | 6.73e-01 | 0.1153 |
| 26520 | TIMM9 | P17T-E | Human | Esophagus | ESCC | 2.20e-10 | 6.80e-01 | 0.1278 |
| 26520 | TIMM9 | P20T-E | Human | Esophagus | ESCC | 9.68e-26 | 5.66e-01 | 0.1124 |
| 26520 | TIMM9 | P21T-E | Human | Esophagus | ESCC | 2.65e-26 | 6.29e-01 | 0.1617 |
| 26520 | TIMM9 | P22T-E | Human | Esophagus | ESCC | 1.03e-28 | 6.32e-01 | 0.1236 |
| Page: 1 2 3 4 5 6 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias | ||
| Liver |  | HCC: Hepatocellular carcinoma |
| NAFLD: Non-alcoholic fatty liver disease | ||
| Oral Cavity |  | EOLP: Erosive Oral lichen planus |
| LP: leukoplakia | ||
| NEOLP: Non-erosive oral lichen planus | ||
| OSCC: Oral squamous cell carcinoma | ||
| Prostate |  | BPH: Benign Prostatic Hyperplasia |
| Skin |  | AK: Actinic keratosis |
| cSCC: Cutaneous squamous cell carcinoma | ||
| SCCIS:squamous cell carcinoma in situ | ||
| Thyroid |  | ATC: Anaplastic thyroid cancer |
| HT: Hashimoto's thyroiditis | ||
| PTC: Papillary thyroid cancer |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:007259420 | Esophagus | HGIN | establishment of protein localization to organelle | 120/2587 | 422/18723 | 1.73e-15 | 4.00e-13 | 120 |
| GO:000683920 | Esophagus | HGIN | mitochondrial transport | 74/2587 | 254/18723 | 1.32e-10 | 1.32e-08 | 74 |
| GO:007058520 | Esophagus | HGIN | protein localization to mitochondrion | 43/2587 | 125/18723 | 4.43e-09 | 3.03e-07 | 43 |
| GO:007265520 | Esophagus | HGIN | establishment of protein localization to mitochondrion | 41/2587 | 120/18723 | 1.26e-08 | 7.96e-07 | 41 |
| GO:000660525 | Esophagus | HGIN | protein targeting | 78/2587 | 314/18723 | 1.08e-07 | 5.47e-06 | 78 |
| GO:009015020 | Esophagus | HGIN | establishment of protein localization to membrane | 67/2587 | 260/18723 | 1.96e-07 | 9.57e-06 | 67 |
| GO:000700618 | Esophagus | HGIN | mitochondrial membrane organization | 37/2587 | 116/18723 | 4.61e-07 | 2.07e-05 | 37 |
| GO:000662620 | Esophagus | HGIN | protein targeting to mitochondrion | 33/2587 | 100/18723 | 7.99e-07 | 3.35e-05 | 33 |
| GO:00512057 | Esophagus | HGIN | protein insertion into membrane | 21/2587 | 57/18723 | 1.16e-05 | 3.29e-04 | 21 |
| GO:00070076 | Esophagus | HGIN | inner mitochondrial membrane organization | 16/2587 | 38/18723 | 1.82e-05 | 4.93e-04 | 16 |
| GO:009015117 | Esophagus | HGIN | establishment of protein localization to mitochondrial membrane | 13/2587 | 30/18723 | 7.76e-05 | 1.74e-03 | 13 |
| GO:00512049 | Esophagus | HGIN | protein insertion into mitochondrial membrane | 10/2587 | 25/18723 | 1.12e-03 | 1.36e-02 | 10 |
| GO:0072594110 | Esophagus | ESCC | establishment of protein localization to organelle | 311/8552 | 422/18723 | 3.02e-32 | 2.13e-29 | 311 |
| GO:0006605111 | Esophagus | ESCC | protein targeting | 229/8552 | 314/18723 | 4.93e-23 | 1.01e-20 | 229 |
| GO:0006839110 | Esophagus | ESCC | mitochondrial transport | 187/8552 | 254/18723 | 8.35e-20 | 9.81e-18 | 187 |
| GO:0090150110 | Esophagus | ESCC | establishment of protein localization to membrane | 182/8552 | 260/18723 | 1.27e-15 | 8.19e-14 | 182 |
| GO:0072655110 | Esophagus | ESCC | establishment of protein localization to mitochondrion | 97/8552 | 120/18723 | 2.17e-15 | 1.33e-13 | 97 |
| GO:0070585110 | Esophagus | ESCC | protein localization to mitochondrion | 100/8552 | 125/18723 | 2.96e-15 | 1.77e-13 | 100 |
| GO:000700619 | Esophagus | ESCC | mitochondrial membrane organization | 93/8552 | 116/18723 | 2.16e-14 | 1.11e-12 | 93 |
| GO:0006626110 | Esophagus | ESCC | protein targeting to mitochondrion | 81/8552 | 100/18723 | 3.60e-13 | 1.67e-11 | 81 |
| Page: 1 2 3 4 5 6 7 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| TIMM9 | SNV | Missense_Mutation | c.176N>C | p.Met59Thr | p.M59T | Q9Y5J7 | protein_coding | tolerated(0.11) | possibly_damaging(0.56) | TCGA-AO-A128-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD | |
| TIMM9 | SNV | Missense_Mutation | novel | c.76G>A | p.Glu26Lys | p.E26K | Q9Y5J7 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
| Page: 1 |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
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