|
|||||
|
 | |
| |
| |
| |
| |
| |
|
Gene: TIMM23B |
Gene summary for TIMM23B |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | TIMM23B | Gene ID | 100652748 |
| Gene name | translocase of inner mitochondrial membrane 23 homolog B | |
| Gene Alias | TIMM23B | |
| Cytomap | 10q11.23 | |
| Gene Type | protein-coding | GO ID | GO:0006605 | UniProtAcc | B4DDK6 |
Top |
Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 100652748 | TIMM23B | HTA11_3410_2000001011 | Human | Colorectum | AD | 1.37e-40 | -1.00e+00 | 0.0155 |
| 100652748 | TIMM23B | HTA11_2487_2000001011 | Human | Colorectum | SER | 4.80e-24 | -9.88e-01 | -0.1808 |
| 100652748 | TIMM23B | HTA11_2951_2000001011 | Human | Colorectum | AD | 3.58e-05 | -9.47e-01 | 0.0216 |
| 100652748 | TIMM23B | HTA11_1938_2000001011 | Human | Colorectum | AD | 1.42e-17 | -9.70e-01 | -0.0811 |
| 100652748 | TIMM23B | HTA11_78_2000001011 | Human | Colorectum | AD | 3.29e-27 | -9.81e-01 | -0.1088 |
| 100652748 | TIMM23B | HTA11_347_2000001011 | Human | Colorectum | AD | 1.13e-36 | -9.43e-01 | -0.1954 |
| 100652748 | TIMM23B | HTA11_2112_2000001011 | Human | Colorectum | SER | 1.10e-05 | -1.01e+00 | -0.2196 |
| 100652748 | TIMM23B | HTA11_3361_2000001011 | Human | Colorectum | AD | 7.18e-20 | -9.97e-01 | -0.1207 |
| 100652748 | TIMM23B | HTA11_83_2000001011 | Human | Colorectum | SER | 3.34e-12 | -9.12e-01 | -0.1526 |
| 100652748 | TIMM23B | HTA11_696_2000001011 | Human | Colorectum | AD | 8.51e-45 | -9.82e-01 | -0.1464 |
| 100652748 | TIMM23B | HTA11_866_2000001011 | Human | Colorectum | AD | 1.37e-39 | -9.54e-01 | -0.1001 |
| 100652748 | TIMM23B | HTA11_1391_2000001011 | Human | Colorectum | AD | 3.20e-26 | -9.17e-01 | -0.059 |
| 100652748 | TIMM23B | HTA11_2992_2000001011 | Human | Colorectum | SER | 9.20e-09 | -1.02e+00 | -0.1706 |
| 100652748 | TIMM23B | HTA11_5212_2000001011 | Human | Colorectum | AD | 3.36e-09 | -9.96e-01 | -0.2061 |
| 100652748 | TIMM23B | HTA11_5216_2000001011 | Human | Colorectum | SER | 4.81e-09 | -1.05e+00 | -0.1462 |
| 100652748 | TIMM23B | HTA11_546_2000001011 | Human | Colorectum | AD | 3.60e-16 | -1.03e+00 | -0.0842 |
| 100652748 | TIMM23B | HTA11_9341_2000001011 | Human | Colorectum | SER | 5.34e-06 | -1.05e+00 | -0.00410000000000005 |
| 100652748 | TIMM23B | HTA11_7862_2000001011 | Human | Colorectum | AD | 4.91e-12 | -1.01e+00 | -0.0179 |
| 100652748 | TIMM23B | HTA11_866_3004761011 | Human | Colorectum | AD | 1.99e-35 | -9.96e-01 | 0.096 |
| 100652748 | TIMM23B | HTA11_4255_2000001011 | Human | Colorectum | SER | 5.27e-05 | -9.47e-01 | 0.0446 |
| Page: 1 2 3 4 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Colorectum (GSE201348) |  | FAP: Familial adenomatous polyposis |
| CRC: Colorectal cancer | ||
| Colorectum (HTA11) |  | AD: Adenomas |
| SER: Sessile serrated lesions | ||
| MSI-H: Microsatellite-high colorectal cancer | ||
| MSS: Microsatellite stable colorectal cancer |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:0006839 | Colorectum | AD | mitochondrial transport | 102/3918 | 254/18723 | 1.87e-12 | 3.08e-10 | 102 |
| GO:0072594 | Colorectum | AD | establishment of protein localization to organelle | 148/3918 | 422/18723 | 7.95e-12 | 1.04e-09 | 148 |
| GO:1990542 | Colorectum | AD | mitochondrial transmembrane transport | 47/3918 | 102/18723 | 1.09e-08 | 6.52e-07 | 47 |
| GO:0006605 | Colorectum | AD | protein targeting | 105/3918 | 314/18723 | 1.39e-07 | 6.44e-06 | 105 |
| GO:0070585 | Colorectum | AD | protein localization to mitochondrion | 51/3918 | 125/18723 | 3.40e-07 | 1.33e-05 | 51 |
| GO:0072655 | Colorectum | AD | establishment of protein localization to mitochondrion | 47/3918 | 120/18723 | 3.76e-06 | 1.04e-04 | 47 |
| GO:0017038 | Colorectum | AD | protein import | 67/3918 | 206/18723 | 6.34e-05 | 1.05e-03 | 67 |
| GO:0006626 | Colorectum | AD | protein targeting to mitochondrion | 37/3918 | 100/18723 | 1.58e-04 | 2.20e-03 | 37 |
| GO:0071806 | Colorectum | AD | protein transmembrane transport | 21/3918 | 59/18723 | 6.58e-03 | 4.08e-02 | 21 |
| GO:00068391 | Colorectum | SER | mitochondrial transport | 87/2897 | 254/18723 | 7.91e-14 | 3.03e-11 | 87 |
| GO:19905421 | Colorectum | SER | mitochondrial transmembrane transport | 42/2897 | 102/18723 | 3.65e-10 | 4.77e-08 | 42 |
| GO:00725941 | Colorectum | SER | establishment of protein localization to organelle | 111/2897 | 422/18723 | 4.98e-09 | 4.49e-07 | 111 |
| GO:00705851 | Colorectum | SER | protein localization to mitochondrion | 42/2897 | 125/18723 | 3.75e-07 | 1.98e-05 | 42 |
| GO:00726551 | Colorectum | SER | establishment of protein localization to mitochondrion | 38/2897 | 120/18723 | 6.60e-06 | 2.33e-04 | 38 |
| GO:00066051 | Colorectum | SER | protein targeting | 76/2897 | 314/18723 | 3.19e-05 | 8.47e-04 | 76 |
| GO:00066261 | Colorectum | SER | protein targeting to mitochondrion | 31/2897 | 100/18723 | 7.09e-05 | 1.61e-03 | 31 |
| GO:00170381 | Colorectum | SER | protein import | 49/2897 | 206/18723 | 1.12e-03 | 1.29e-02 | 49 |
| GO:00718061 | Colorectum | SER | protein transmembrane transport | 17/2897 | 59/18723 | 6.64e-03 | 4.69e-02 | 17 |
| GO:00725942 | Colorectum | MSS | establishment of protein localization to organelle | 139/3467 | 422/18723 | 5.75e-13 | 1.12e-10 | 139 |
| GO:00068392 | Colorectum | MSS | mitochondrial transport | 93/3467 | 254/18723 | 6.14e-12 | 9.82e-10 | 93 |
| Page: 1 2 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
Top |
Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| TIMM23B | SNV | Missense_Mutation | novel | c.220N>C | p.Glu74Gln | p.E74Q | Q5SRD1 | protein_coding | deleterious(0) | possibly_damaging(0.486) | TCGA-A8-A06X-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| TIMM23B | SNV | Missense_Mutation | novel | c.46N>A | p.Ala16Thr | p.A16T | Q5SRD1 | protein_coding | deleterious_low_confidence(0.02) | benign(0.022) | TCGA-AA-3492-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| TIMM23B | SNV | Missense_Mutation | novel | c.79T>G | p.Ser27Ala | p.S27A | Q5SRD1 | protein_coding | tolerated_low_confidence(0.23) | benign(0.383) | TCGA-DM-A1DA-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
| TIMM23B | SNV | Missense_Mutation | novel | c.286N>A | p.Leu96Ile | p.L96I | Q5SRD1 | protein_coding | tolerated(0.06) | possibly_damaging(0.692) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
| TIMM23B | SNV | Missense_Mutation | novel | c.289N>T | p.Arg97Trp | p.R97W | Q5SRD1 | protein_coding | tolerated(0.13) | probably_damaging(0.961) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
| TIMM23B | SNV | Missense_Mutation | novel | c.238N>G | p.Ile80Val | p.I80V | Q5SRD1 | protein_coding | deleterious(0.01) | benign(0.169) | TCGA-AP-A051-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| TIMM23B | SNV | Missense_Mutation | novel | c.337N>C | p.Asn113His | p.N113H | Q5SRD1 | protein_coding | tolerated(0.12) | benign(0.222) | TCGA-B5-A3FC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
| TIMM23B | SNV | Missense_Mutation | novel | c.277N>G | p.Met93Val | p.M93V | Q5SRD1 | protein_coding | tolerated(1) | benign(0) | TCGA-EO-A3AS-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| TIMM23B | SNV | Missense_Mutation | novel | c.368A>C | p.Gln123Pro | p.Q123P | Q5SRD1 | protein_coding | deleterious(0.02) | probably_damaging(0.921) | TCGA-21-1075-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
| TIMM23B | SNV | Missense_Mutation | novel | c.373N>T | p.Ala125Ser | p.A125S | Q5SRD1 | protein_coding | tolerated(0.21) | probably_damaging(0.929) | TCGA-63-7023-01 | Lung | lung squamous cell carcinoma | Male | Unknown | I/II | Unspecific | Vinorelbine Tartrate | SD |
| Page: 1 2 |
Top |
Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
Copyright 2023-Present -The University of Texas Health Science Center at Houston |