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Gene: TIMM22 |
Gene summary for TIMM22 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | TIMM22 | Gene ID | 29928 |
| Gene name | translocase of inner mitochondrial membrane 22 | |
| Gene Alias | COXPD43 | |
| Cytomap | 17p13.3 | |
| Gene Type | protein-coding | GO ID | GO:0006605 | UniProtAcc | Q9Y584 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 29928 | TIMM22 | LZE4T | Human | Esophagus | ESCC | 6.75e-08 | 2.73e-01 | 0.0811 |
| 29928 | TIMM22 | LZE7T | Human | Esophagus | ESCC | 3.41e-14 | 3.81e-01 | 0.0667 |
| 29928 | TIMM22 | LZE8T | Human | Esophagus | ESCC | 2.95e-03 | 7.55e-02 | 0.067 |
| 29928 | TIMM22 | LZE22T | Human | Esophagus | ESCC | 2.05e-06 | 5.27e-01 | 0.068 |
| 29928 | TIMM22 | LZE24T | Human | Esophagus | ESCC | 9.25e-19 | 3.64e-01 | 0.0596 |
| 29928 | TIMM22 | LZE21T | Human | Esophagus | ESCC | 1.52e-02 | 1.97e-01 | 0.0655 |
| 29928 | TIMM22 | LZE6T | Human | Esophagus | ESCC | 8.10e-07 | 2.60e-01 | 0.0845 |
| 29928 | TIMM22 | P1T-E | Human | Esophagus | ESCC | 2.11e-04 | 2.50e-01 | 0.0875 |
| 29928 | TIMM22 | P2T-E | Human | Esophagus | ESCC | 1.24e-27 | 3.14e-01 | 0.1177 |
| 29928 | TIMM22 | P4T-E | Human | Esophagus | ESCC | 6.11e-28 | 6.92e-01 | 0.1323 |
| 29928 | TIMM22 | P5T-E | Human | Esophagus | ESCC | 1.58e-16 | 3.01e-01 | 0.1327 |
| 29928 | TIMM22 | P8T-E | Human | Esophagus | ESCC | 5.58e-14 | 2.48e-01 | 0.0889 |
| 29928 | TIMM22 | P9T-E | Human | Esophagus | ESCC | 7.47e-11 | 2.46e-01 | 0.1131 |
| 29928 | TIMM22 | P10T-E | Human | Esophagus | ESCC | 8.07e-20 | 3.09e-01 | 0.116 |
| 29928 | TIMM22 | P11T-E | Human | Esophagus | ESCC | 1.32e-14 | 3.09e-01 | 0.1426 |
| 29928 | TIMM22 | P12T-E | Human | Esophagus | ESCC | 9.84e-19 | 4.23e-01 | 0.1122 |
| 29928 | TIMM22 | P15T-E | Human | Esophagus | ESCC | 5.31e-22 | 2.56e-01 | 0.1149 |
| 29928 | TIMM22 | P16T-E | Human | Esophagus | ESCC | 1.84e-23 | 4.30e-01 | 0.1153 |
| 29928 | TIMM22 | P17T-E | Human | Esophagus | ESCC | 1.91e-08 | 3.21e-01 | 0.1278 |
| 29928 | TIMM22 | P19T-E | Human | Esophagus | ESCC | 1.08e-04 | 8.19e-01 | 0.1662 |
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| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias | ||
| Oral Cavity |  | EOLP: Erosive Oral lichen planus |
| LP: leukoplakia | ||
| NEOLP: Non-erosive oral lichen planus | ||
| OSCC: Oral squamous cell carcinoma | ||
| Skin |  | AK: Actinic keratosis |
| cSCC: Cutaneous squamous cell carcinoma | ||
| SCCIS:squamous cell carcinoma in situ | ||
| Thyroid |  | ATC: Anaplastic thyroid cancer |
| HT: Hashimoto's thyroiditis | ||
| PTC: Papillary thyroid cancer |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:0072594110 | Esophagus | ESCC | establishment of protein localization to organelle | 311/8552 | 422/18723 | 3.02e-32 | 2.13e-29 | 311 |
| GO:0006605111 | Esophagus | ESCC | protein targeting | 229/8552 | 314/18723 | 4.93e-23 | 1.01e-20 | 229 |
| GO:0006839110 | Esophagus | ESCC | mitochondrial transport | 187/8552 | 254/18723 | 8.35e-20 | 9.81e-18 | 187 |
| GO:0090150110 | Esophagus | ESCC | establishment of protein localization to membrane | 182/8552 | 260/18723 | 1.27e-15 | 8.19e-14 | 182 |
| GO:0072655110 | Esophagus | ESCC | establishment of protein localization to mitochondrion | 97/8552 | 120/18723 | 2.17e-15 | 1.33e-13 | 97 |
| GO:0070585110 | Esophagus | ESCC | protein localization to mitochondrion | 100/8552 | 125/18723 | 2.96e-15 | 1.77e-13 | 100 |
| GO:000700619 | Esophagus | ESCC | mitochondrial membrane organization | 93/8552 | 116/18723 | 2.16e-14 | 1.11e-12 | 93 |
| GO:0006626110 | Esophagus | ESCC | protein targeting to mitochondrion | 81/8552 | 100/18723 | 3.60e-13 | 1.67e-11 | 81 |
| GO:005120515 | Esophagus | ESCC | protein insertion into membrane | 46/8552 | 57/18723 | 5.90e-08 | 1.04e-06 | 46 |
| GO:00718069 | Esophagus | ESCC | protein transmembrane transport | 47/8552 | 59/18723 | 9.02e-08 | 1.51e-06 | 47 |
| GO:009015118 | Esophagus | ESCC | establishment of protein localization to mitochondrial membrane | 26/8552 | 30/18723 | 3.79e-06 | 4.12e-05 | 26 |
| GO:000700713 | Esophagus | ESCC | inner mitochondrial membrane organization | 31/8552 | 38/18723 | 5.93e-06 | 6.10e-05 | 31 |
| GO:005120416 | Esophagus | ESCC | protein insertion into mitochondrial membrane | 21/8552 | 25/18723 | 9.12e-05 | 6.54e-04 | 21 |
| GO:00450393 | Esophagus | ESCC | protein insertion into mitochondrial inner membrane | 11/8552 | 12/18723 | 1.26e-03 | 6.06e-03 | 11 |
| GO:007259418 | Oral cavity | OSCC | establishment of protein localization to organelle | 284/7305 | 422/18723 | 1.50e-32 | 1.35e-29 | 284 |
| GO:000660520 | Oral cavity | OSCC | protein targeting | 204/7305 | 314/18723 | 6.78e-21 | 1.13e-18 | 204 |
| GO:000683918 | Oral cavity | OSCC | mitochondrial transport | 162/7305 | 254/18723 | 8.96e-16 | 6.52e-14 | 162 |
| GO:009015018 | Oral cavity | OSCC | establishment of protein localization to membrane | 163/7305 | 260/18723 | 7.13e-15 | 4.47e-13 | 163 |
| GO:007058518 | Oral cavity | OSCC | protein localization to mitochondrion | 91/7305 | 125/18723 | 1.60e-14 | 9.27e-13 | 91 |
| GO:007265518 | Oral cavity | OSCC | establishment of protein localization to mitochondrion | 88/7305 | 120/18723 | 2.10e-14 | 1.19e-12 | 88 |
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| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| TIMM22 | SNV | Missense_Mutation | c.118N>T | p.Arg40Trp | p.R40W | Q9Y584 | protein_coding | tolerated(0.17) | benign(0) | TCGA-BH-A0HN-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD | |
| TIMM22 | SNV | Missense_Mutation | novel | c.172G>A | p.Glu58Lys | p.E58K | Q9Y584 | protein_coding | deleterious(0.01) | benign(0.409) | TCGA-JW-A5VL-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
| TIMM22 | SNV | Missense_Mutation | c.322N>G | p.Thr108Ala | p.T108A | Q9Y584 | protein_coding | tolerated(0.22) | benign(0.044) | TCGA-AA-3510-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
| TIMM22 | SNV | Missense_Mutation | novel | c.128A>C | p.Glu43Ala | p.E43A | Q9Y584 | protein_coding | tolerated(0.74) | benign(0.018) | TCGA-AA-3949-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
| TIMM22 | SNV | Missense_Mutation | novel | c.517N>C | p.Lys173Gln | p.K173Q | Q9Y584 | protein_coding | deleterious(0.02) | benign(0.071) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
| TIMM22 | SNV | Missense_Mutation | novel | c.467N>G | p.Val156Gly | p.V156G | Q9Y584 | protein_coding | deleterious(0.01) | possibly_damaging(0.522) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
| TIMM22 | SNV | Missense_Mutation | rs142652142 | c.274N>A | p.Ala92Thr | p.A92T | Q9Y584 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-CM-6162-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Chemotherapy | oxaliplatin | SD |
| TIMM22 | SNV | Missense_Mutation | c.121N>T | p.Leu41Phe | p.L41F | Q9Y584 | protein_coding | deleterious(0.05) | benign(0.033) | TCGA-AG-A02N-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | I/II | Chemotherapy | folinic | CR | |
| TIMM22 | SNV | Missense_Mutation | novel | c.305N>A | p.Pro102His | p.P102H | Q9Y584 | protein_coding | deleterious(0.01) | probably_damaging(0.938) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| TIMM22 | SNV | Missense_Mutation | rs372574724 | c.146N>A | p.Gly49Glu | p.G49E | Q9Y584 | protein_coding | tolerated(0.1) | possibly_damaging(0.784) | TCGA-AP-A1DK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
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