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Gene: TIMM17B |
Gene summary for TIMM17B |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | TIMM17B | Gene ID | 10245 |
| Gene name | translocase of inner mitochondrial membrane 17B | |
| Gene Alias | DXS9822 | |
| Cytomap | Xp11.23 | |
| Gene Type | protein-coding | GO ID | GO:0006605 | UniProtAcc | O60830 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 10245 | TIMM17B | HTA11_3410_2000001011 | Human | Colorectum | AD | 1.23e-04 | 1.07e-01 | 0.0155 |
| 10245 | TIMM17B | HTA11_2487_2000001011 | Human | Colorectum | SER | 2.86e-10 | 2.51e-01 | -0.1808 |
| 10245 | TIMM17B | HTA11_1938_2000001011 | Human | Colorectum | AD | 1.73e-09 | 2.60e-01 | -0.0811 |
| 10245 | TIMM17B | HTA11_78_2000001011 | Human | Colorectum | AD | 6.68e-05 | 1.52e-01 | -0.1088 |
| 10245 | TIMM17B | HTA11_347_2000001011 | Human | Colorectum | AD | 2.61e-17 | 3.04e-01 | -0.1954 |
| 10245 | TIMM17B | HTA11_411_2000001011 | Human | Colorectum | SER | 1.86e-06 | 3.87e-01 | -0.2602 |
| 10245 | TIMM17B | HTA11_2112_2000001011 | Human | Colorectum | SER | 1.71e-03 | 3.51e-01 | -0.2196 |
| 10245 | TIMM17B | HTA11_3361_2000001011 | Human | Colorectum | AD | 1.34e-03 | 1.86e-01 | -0.1207 |
| 10245 | TIMM17B | HTA11_83_2000001011 | Human | Colorectum | SER | 2.92e-07 | 2.29e-01 | -0.1526 |
| 10245 | TIMM17B | HTA11_696_2000001011 | Human | Colorectum | AD | 7.69e-09 | 2.64e-01 | -0.1464 |
| 10245 | TIMM17B | HTA11_866_2000001011 | Human | Colorectum | AD | 1.76e-02 | 1.36e-01 | -0.1001 |
| 10245 | TIMM17B | HTA11_1391_2000001011 | Human | Colorectum | AD | 2.44e-13 | 3.16e-01 | -0.059 |
| 10245 | TIMM17B | HTA11_2992_2000001011 | Human | Colorectum | SER | 1.29e-03 | 2.23e-01 | -0.1706 |
| 10245 | TIMM17B | HTA11_5212_2000001011 | Human | Colorectum | AD | 3.97e-04 | 1.99e-01 | -0.2061 |
| 10245 | TIMM17B | HTA11_5216_2000001011 | Human | Colorectum | SER | 3.22e-05 | 3.20e-01 | -0.1462 |
| 10245 | TIMM17B | HTA11_546_2000001011 | Human | Colorectum | AD | 2.65e-04 | 1.83e-01 | -0.0842 |
| 10245 | TIMM17B | HTA11_866_3004761011 | Human | Colorectum | AD | 2.04e-08 | 1.73e-01 | 0.096 |
| 10245 | TIMM17B | HTA11_10623_2000001011 | Human | Colorectum | AD | 2.05e-04 | 2.47e-01 | -0.0177 |
| 10245 | TIMM17B | HTA11_10711_2000001011 | Human | Colorectum | AD | 2.62e-06 | 1.96e-01 | 0.0338 |
| 10245 | TIMM17B | HTA11_7696_3000711011 | Human | Colorectum | AD | 6.22e-04 | 1.94e-01 | 0.0674 |
| Page: 1 2 3 4 5 6 7 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Colorectum (GSE201348) |  | FAP: Familial adenomatous polyposis |
| CRC: Colorectal cancer | ||
| Colorectum (HTA11) |  | AD: Adenomas |
| SER: Sessile serrated lesions | ||
| MSI-H: Microsatellite-high colorectal cancer | ||
| MSS: Microsatellite stable colorectal cancer | ||
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias | ||
| Liver |  | HCC: Hepatocellular carcinoma |
| NAFLD: Non-alcoholic fatty liver disease | ||
| Oral Cavity |  | EOLP: Erosive Oral lichen planus |
| LP: leukoplakia | ||
| NEOLP: Non-erosive oral lichen planus | ||
| OSCC: Oral squamous cell carcinoma | ||
| Prostate |  | BPH: Benign Prostatic Hyperplasia |
| Skin |  | AK: Actinic keratosis |
| cSCC: Cutaneous squamous cell carcinoma | ||
| SCCIS:squamous cell carcinoma in situ |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:0006839 | Colorectum | AD | mitochondrial transport | 102/3918 | 254/18723 | 1.87e-12 | 3.08e-10 | 102 |
| GO:0072594 | Colorectum | AD | establishment of protein localization to organelle | 148/3918 | 422/18723 | 7.95e-12 | 1.04e-09 | 148 |
| GO:1990542 | Colorectum | AD | mitochondrial transmembrane transport | 47/3918 | 102/18723 | 1.09e-08 | 6.52e-07 | 47 |
| GO:0006605 | Colorectum | AD | protein targeting | 105/3918 | 314/18723 | 1.39e-07 | 6.44e-06 | 105 |
| GO:0070585 | Colorectum | AD | protein localization to mitochondrion | 51/3918 | 125/18723 | 3.40e-07 | 1.33e-05 | 51 |
| GO:0072655 | Colorectum | AD | establishment of protein localization to mitochondrion | 47/3918 | 120/18723 | 3.76e-06 | 1.04e-04 | 47 |
| GO:0017038 | Colorectum | AD | protein import | 67/3918 | 206/18723 | 6.34e-05 | 1.05e-03 | 67 |
| GO:0006626 | Colorectum | AD | protein targeting to mitochondrion | 37/3918 | 100/18723 | 1.58e-04 | 2.20e-03 | 37 |
| GO:0071806 | Colorectum | AD | protein transmembrane transport | 21/3918 | 59/18723 | 6.58e-03 | 4.08e-02 | 21 |
| GO:00068391 | Colorectum | SER | mitochondrial transport | 87/2897 | 254/18723 | 7.91e-14 | 3.03e-11 | 87 |
| GO:19905421 | Colorectum | SER | mitochondrial transmembrane transport | 42/2897 | 102/18723 | 3.65e-10 | 4.77e-08 | 42 |
| GO:00725941 | Colorectum | SER | establishment of protein localization to organelle | 111/2897 | 422/18723 | 4.98e-09 | 4.49e-07 | 111 |
| GO:00705851 | Colorectum | SER | protein localization to mitochondrion | 42/2897 | 125/18723 | 3.75e-07 | 1.98e-05 | 42 |
| GO:00726551 | Colorectum | SER | establishment of protein localization to mitochondrion | 38/2897 | 120/18723 | 6.60e-06 | 2.33e-04 | 38 |
| GO:00066051 | Colorectum | SER | protein targeting | 76/2897 | 314/18723 | 3.19e-05 | 8.47e-04 | 76 |
| GO:00066261 | Colorectum | SER | protein targeting to mitochondrion | 31/2897 | 100/18723 | 7.09e-05 | 1.61e-03 | 31 |
| GO:00170381 | Colorectum | SER | protein import | 49/2897 | 206/18723 | 1.12e-03 | 1.29e-02 | 49 |
| GO:00718061 | Colorectum | SER | protein transmembrane transport | 17/2897 | 59/18723 | 6.64e-03 | 4.69e-02 | 17 |
| GO:00725942 | Colorectum | MSS | establishment of protein localization to organelle | 139/3467 | 422/18723 | 5.75e-13 | 1.12e-10 | 139 |
| GO:00068392 | Colorectum | MSS | mitochondrial transport | 93/3467 | 254/18723 | 6.14e-12 | 9.82e-10 | 93 |
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| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| TIMM17B | SNV | Missense_Mutation | c.542N>C | p.Ile181Thr | p.I181T | O60830 | protein_coding | deleterious(0) | probably_damaging(0.969) | TCGA-A2-A0T0-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxotere | SD | |
| TIMM17B | insertion | Frame_Shift_Ins | novel | c.225_226insTGTAAACATTTGTCAACTCCCCATAAAGATGAAGGGAATGTTG | p.Thr76CysfsTer40 | p.T76Cfs*40 | O60830 | protein_coding | TCGA-B6-A0IA-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
| TIMM17B | insertion | In_Frame_Ins | novel | c.89_97dupTCTTCCAGG | p.Val30_Gln32dup | p.V30_Q32dup | O60830 | protein_coding | TCGA-UL-AAZ6-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | herceptin | SD | ||
| TIMM17B | SNV | Missense_Mutation | c.466N>T | p.Arg156Cys | p.R156C | O60830 | protein_coding | deleterious(0.02) | benign(0.233) | TCGA-CM-6162-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Chemotherapy | oxaliplatin | SD | |
| TIMM17B | SNV | Missense_Mutation | novel | c.13G>A | p.Ala5Thr | p.A5T | O60830 | protein_coding | tolerated(0.39) | possibly_damaging(0.578) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| TIMM17B | SNV | Missense_Mutation | novel | c.112N>T | p.Arg38Cys | p.R38C | O60830 | protein_coding | deleterious(0) | benign(0.104) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
| TIMM17B | SNV | Missense_Mutation | novel | c.58G>A | p.Ala20Thr | p.A20T | O60830 | protein_coding | deleterious(0) | probably_damaging(0.947) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
| TIMM17B | SNV | Missense_Mutation | novel | c.586C>A | p.Pro196Thr | p.P196T | O60830 | protein_coding | tolerated(0.06) | possibly_damaging(0.844) | TCGA-AP-A1DK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
| TIMM17B | SNV | Missense_Mutation | novel | c.113N>A | p.Arg38His | p.R38H | O60830 | protein_coding | deleterious(0.01) | benign(0.33) | TCGA-AP-A1DV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
| TIMM17B | SNV | Missense_Mutation | novel | c.400N>T | p.Arg134Trp | p.R134W | O60830 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-AP-A1E0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | SD |
| Page: 1 2 3 |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
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