![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: TIGD5 |
Gene summary for TIGD5 |
![]() |
Gene information | Species | Human | Gene symbol | TIGD5 | Gene ID | 84948 |
Gene name | tigger transposable element derived 5 | |
Gene Alias | TIGD5 | |
Cytomap | 8q24.3 | |
Gene Type | protein-coding | GO ID | GO:0008150 | UniProtAcc | Q53EQ6 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
84948 | TIGD5 | HCC1_Meng | Human | Liver | HCC | 5.15e-28 | 3.92e-02 | 0.0246 |
84948 | TIGD5 | HCC2_Meng | Human | Liver | HCC | 3.43e-02 | 2.55e-02 | 0.0107 |
84948 | TIGD5 | S014 | Human | Liver | HCC | 1.23e-12 | 4.05e-01 | 0.2254 |
84948 | TIGD5 | S015 | Human | Liver | HCC | 2.96e-08 | 3.52e-01 | 0.2375 |
84948 | TIGD5 | S016 | Human | Liver | HCC | 7.20e-11 | 3.40e-01 | 0.2243 |
84948 | TIGD5 | S027 | Human | Liver | HCC | 7.10e-10 | 6.54e-01 | 0.2446 |
84948 | TIGD5 | S028 | Human | Liver | HCC | 3.79e-19 | 5.95e-01 | 0.2503 |
84948 | TIGD5 | S029 | Human | Liver | HCC | 8.74e-17 | 5.73e-01 | 0.2581 |
Page: 1 |
![]() |
Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TIGD5 | SNV | Missense_Mutation | rs760644970 | c.1711G>A | p.Gly571Arg | p.G571R | Q53EQ6 | protein_coding | tolerated(0.57) | benign(0.027) | TCGA-EA-A410-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
TIGD5 | SNV | Missense_Mutation | c.1190G>A | p.Gly397Asp | p.G397D | Q53EQ6 | protein_coding | deleterious(0) | probably_damaging(0.988) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
TIGD5 | SNV | Missense_Mutation | c.1592A>G | p.Glu531Gly | p.E531G | Q53EQ6 | protein_coding | tolerated(0.05) | benign(0.015) | TCGA-AM-5821-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
TIGD5 | SNV | Missense_Mutation | c.1771N>A | p.Ala591Thr | p.A591T | Q53EQ6 | protein_coding | deleterious(0) | probably_damaging(0.972) | TCGA-WS-AB45-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
TIGD5 | SNV | Missense_Mutation | c.1209N>G | p.Phe403Leu | p.F403L | Q53EQ6 | protein_coding | deleterious(0.01) | benign(0.203) | TCGA-AF-6655-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
TIGD5 | insertion | In_Frame_Ins | novel | c.318_319insCAA | p.Gly106_Gly107insGln | p.G106_G107insQ | Q53EQ6 | protein_coding | TCGA-D5-6534-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
TIGD5 | SNV | Missense_Mutation | novel | c.1919N>G | p.Asp640Gly | p.D640G | Q53EQ6 | protein_coding | tolerated_low_confidence(0.1) | benign(0.003) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TIGD5 | SNV | Missense_Mutation | novel | c.1838T>C | p.Leu613Pro | p.L613P | Q53EQ6 | protein_coding | tolerated(0.09) | benign(0.003) | TCGA-AP-A1DK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TIGD5 | SNV | Missense_Mutation | rs760644970 | c.1711N>A | p.Gly571Arg | p.G571R | Q53EQ6 | protein_coding | tolerated(0.57) | benign(0.027) | TCGA-B5-A11Y-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TIGD5 | SNV | Missense_Mutation | novel | c.1357N>G | p.Met453Val | p.M453V | Q53EQ6 | protein_coding | tolerated(0.24) | benign(0) | TCGA-D1-A175-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | paclitaxel | SD |
Page: 1 2 3 4 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |