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Gene: THNSL1 |
Gene summary for THNSL1 |
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Gene information | Species | Human | Gene symbol | THNSL1 | Gene ID | 79896 |
Gene name | threonine synthase like 1 | |
Gene Alias | TSH1 | |
Cytomap | 10p12.1 | |
Gene Type | protein-coding | GO ID | GO:0008150 | UniProtAcc | Q8IYQ7 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
79896 | THNSL1 | HCC1_Meng | Human | Liver | HCC | 2.89e-18 | 2.91e-02 | 0.0246 |
79896 | THNSL1 | HCC1 | Human | Liver | HCC | 1.70e-04 | 3.12e+00 | 0.5336 |
79896 | THNSL1 | HCC2 | Human | Liver | HCC | 6.93e-03 | 1.31e+00 | 0.5341 |
79896 | THNSL1 | S014 | Human | Liver | HCC | 1.45e-07 | 2.36e-01 | 0.2254 |
79896 | THNSL1 | S015 | Human | Liver | HCC | 8.45e-07 | 2.31e-01 | 0.2375 |
79896 | THNSL1 | S016 | Human | Liver | HCC | 6.38e-07 | 2.70e-01 | 0.2243 |
79896 | THNSL1 | S028 | Human | Liver | HCC | 9.65e-07 | 2.22e-01 | 0.2503 |
79896 | THNSL1 | S029 | Human | Liver | HCC | 5.82e-05 | 1.92e-01 | 0.2581 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
THNSL1 | SNV | Missense_Mutation | novel | c.989N>C | p.Val330Ala | p.V330A | Q8IYQ7 | protein_coding | deleterious(0) | probably_damaging(0.966) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
THNSL1 | SNV | Missense_Mutation | c.854N>T | p.Gly285Val | p.G285V | Q8IYQ7 | protein_coding | tolerated(0.21) | benign(0.197) | TCGA-D8-A141-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicine | SD | |
THNSL1 | SNV | Missense_Mutation | c.1259N>G | p.Ile420Arg | p.I420R | Q8IYQ7 | protein_coding | deleterious(0) | possibly_damaging(0.756) | TCGA-D8-A1JK-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
THNSL1 | SNV | Missense_Mutation | novel | c.1931N>T | p.Ala644Val | p.A644V | Q8IYQ7 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-GI-A2C9-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unspecific | SD | |
THNSL1 | SNV | Missense_Mutation | novel | c.220N>C | p.Ile74Leu | p.I74L | Q8IYQ7 | protein_coding | tolerated(0.08) | benign(0.416) | TCGA-LL-A5YO-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxotere | CR |
THNSL1 | SNV | Missense_Mutation | rs565237106 | c.1337G>T | p.Arg446Ile | p.R446I | Q8IYQ7 | protein_coding | deleterious(0.04) | benign(0.184) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
THNSL1 | SNV | Missense_Mutation | novel | c.2103A>T | p.Leu701Phe | p.L701F | Q8IYQ7 | protein_coding | tolerated(0.24) | possibly_damaging(0.862) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
THNSL1 | SNV | Missense_Mutation | c.1270C>G | p.Gln424Glu | p.Q424E | Q8IYQ7 | protein_coding | tolerated(0.21) | possibly_damaging(0.519) | TCGA-DR-A0ZM-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unspecific | Cisplatin | SD | |
THNSL1 | SNV | Missense_Mutation | c.404N>C | p.Asn135Thr | p.N135T | Q8IYQ7 | protein_coding | deleterious(0.04) | benign(0.104) | TCGA-AA-3510-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
THNSL1 | SNV | Missense_Mutation | c.1199N>T | p.Arg400Met | p.R400M | Q8IYQ7 | protein_coding | deleterious(0.04) | probably_damaging(0.942) | TCGA-AA-3833-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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