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Gene: THEM6 |
Gene summary for THEM6 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | THEM6 | Gene ID | 51337 |
| Gene name | thioesterase superfamily member 6 | |
| Gene Alias | C8orf55 | |
| Cytomap | 8q24.3 | |
| Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | Q8WUY1 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 51337 | THEM6 | LZE5T | Human | Esophagus | ESCC | 4.21e-02 | 3.22e-01 | 0.0514 |
| 51337 | THEM6 | LZE22T | Human | Esophagus | ESCC | 1.22e-02 | 4.00e-01 | 0.068 |
| 51337 | THEM6 | LZE24T | Human | Esophagus | ESCC | 8.05e-11 | 4.38e-01 | 0.0596 |
| 51337 | THEM6 | P1T-E | Human | Esophagus | ESCC | 2.19e-04 | 3.90e-01 | 0.0875 |
| 51337 | THEM6 | P2T-E | Human | Esophagus | ESCC | 4.85e-12 | 2.84e-01 | 0.1177 |
| 51337 | THEM6 | P4T-E | Human | Esophagus | ESCC | 9.97e-14 | 3.46e-01 | 0.1323 |
| 51337 | THEM6 | P5T-E | Human | Esophagus | ESCC | 7.21e-18 | 4.34e-01 | 0.1327 |
| 51337 | THEM6 | P8T-E | Human | Esophagus | ESCC | 2.36e-26 | 5.39e-01 | 0.0889 |
| 51337 | THEM6 | P9T-E | Human | Esophagus | ESCC | 1.12e-10 | 2.85e-01 | 0.1131 |
| 51337 | THEM6 | P10T-E | Human | Esophagus | ESCC | 3.34e-10 | 2.12e-01 | 0.116 |
| 51337 | THEM6 | P11T-E | Human | Esophagus | ESCC | 4.65e-14 | 6.65e-01 | 0.1426 |
| 51337 | THEM6 | P12T-E | Human | Esophagus | ESCC | 1.16e-10 | 2.56e-01 | 0.1122 |
| 51337 | THEM6 | P15T-E | Human | Esophagus | ESCC | 1.25e-18 | 4.94e-01 | 0.1149 |
| 51337 | THEM6 | P16T-E | Human | Esophagus | ESCC | 1.55e-22 | 5.15e-01 | 0.1153 |
| 51337 | THEM6 | P17T-E | Human | Esophagus | ESCC | 4.48e-08 | 3.88e-01 | 0.1278 |
| 51337 | THEM6 | P20T-E | Human | Esophagus | ESCC | 1.28e-25 | 5.30e-01 | 0.1124 |
| 51337 | THEM6 | P21T-E | Human | Esophagus | ESCC | 2.46e-40 | 7.89e-01 | 0.1617 |
| 51337 | THEM6 | P22T-E | Human | Esophagus | ESCC | 8.39e-06 | 1.24e-01 | 0.1236 |
| 51337 | THEM6 | P23T-E | Human | Esophagus | ESCC | 4.94e-31 | 9.17e-01 | 0.108 |
| 51337 | THEM6 | P24T-E | Human | Esophagus | ESCC | 3.57e-15 | 3.09e-01 | 0.1287 |
| Page: 1 2 3 4 5 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias | ||
| Liver |  | HCC: Hepatocellular carcinoma |
| NAFLD: Non-alcoholic fatty liver disease | ||
| Oral Cavity |  | EOLP: Erosive Oral lichen planus |
| LP: leukoplakia | ||
| NEOLP: Non-erosive oral lichen planus | ||
| OSCC: Oral squamous cell carcinoma |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| Page: 1 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| THEM6 | SNV | Missense_Mutation | c.519N>T | p.Glu173Asp | p.E173D | Q8WUY1 | protein_coding | tolerated(0.23) | benign(0.04) | TCGA-AA-3972-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | capecitabine | PD | |
| THEM6 | SNV | Missense_Mutation | rs200343822 | c.535N>A | p.Ala179Thr | p.A179T | Q8WUY1 | protein_coding | tolerated(0.06) | benign(0.335) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| THEM6 | SNV | Missense_Mutation | rs764843549 | c.563A>G | p.Asn188Ser | p.N188S | Q8WUY1 | protein_coding | tolerated(0.14) | possibly_damaging(0.628) | TCGA-EO-A2CG-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | CR |
| Page: 1 |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
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