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Gene: THAP6 |
Gene summary for THAP6 |
Gene summary. |
Gene information | Species | Human | Gene symbol | THAP6 | Gene ID | 152815 |
Gene name | THAP domain containing 6 | |
Gene Alias | THAP6 | |
Cytomap | 4q21.1 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | Q8TBB0 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
152815 | THAP6 | LZE4T | Human | Esophagus | ESCC | 9.29e-05 | 1.26e-01 | 0.0811 |
152815 | THAP6 | LZE24T | Human | Esophagus | ESCC | 1.96e-03 | 1.26e-01 | 0.0596 |
152815 | THAP6 | P2T-E | Human | Esophagus | ESCC | 6.34e-10 | 2.46e-01 | 0.1177 |
152815 | THAP6 | P4T-E | Human | Esophagus | ESCC | 7.12e-12 | 2.26e-01 | 0.1323 |
152815 | THAP6 | P5T-E | Human | Esophagus | ESCC | 8.70e-12 | 1.53e-01 | 0.1327 |
152815 | THAP6 | P8T-E | Human | Esophagus | ESCC | 3.80e-08 | 1.48e-01 | 0.0889 |
152815 | THAP6 | P9T-E | Human | Esophagus | ESCC | 9.36e-03 | 8.50e-02 | 0.1131 |
152815 | THAP6 | P10T-E | Human | Esophagus | ESCC | 1.18e-09 | 2.03e-01 | 0.116 |
152815 | THAP6 | P11T-E | Human | Esophagus | ESCC | 1.53e-07 | 3.06e-01 | 0.1426 |
152815 | THAP6 | P12T-E | Human | Esophagus | ESCC | 1.86e-07 | 1.80e-01 | 0.1122 |
152815 | THAP6 | P15T-E | Human | Esophagus | ESCC | 2.23e-11 | 1.87e-01 | 0.1149 |
152815 | THAP6 | P16T-E | Human | Esophagus | ESCC | 1.42e-10 | 2.83e-01 | 0.1153 |
152815 | THAP6 | P17T-E | Human | Esophagus | ESCC | 3.93e-03 | 1.90e-01 | 0.1278 |
152815 | THAP6 | P20T-E | Human | Esophagus | ESCC | 2.88e-11 | 1.74e-01 | 0.1124 |
152815 | THAP6 | P21T-E | Human | Esophagus | ESCC | 3.36e-09 | 1.96e-01 | 0.1617 |
152815 | THAP6 | P22T-E | Human | Esophagus | ESCC | 6.34e-11 | 1.66e-01 | 0.1236 |
152815 | THAP6 | P23T-E | Human | Esophagus | ESCC | 8.55e-11 | 1.47e-01 | 0.108 |
152815 | THAP6 | P24T-E | Human | Esophagus | ESCC | 8.88e-06 | 1.60e-01 | 0.1287 |
152815 | THAP6 | P26T-E | Human | Esophagus | ESCC | 1.41e-18 | 3.15e-01 | 0.1276 |
152815 | THAP6 | P27T-E | Human | Esophagus | ESCC | 2.47e-08 | 1.50e-01 | 0.1055 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
THAP6 | SNV | Missense_Mutation | c.492N>A | p.Asp164Glu | p.D164E | Q8TBB0 | protein_coding | tolerated(0.49) | benign(0.055) | TCGA-CK-4951-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
THAP6 | SNV | Missense_Mutation | novel | c.295N>G | p.Arg99Gly | p.R99G | Q8TBB0 | protein_coding | tolerated(0.4) | benign(0.025) | TCGA-CM-6674-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
THAP6 | SNV | Missense_Mutation | novel | c.305N>G | p.Leu102Arg | p.L102R | Q8TBB0 | protein_coding | tolerated(0.46) | benign(0.293) | TCGA-A5-A2K5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
THAP6 | SNV | Missense_Mutation | c.53N>T | p.Ser18Leu | p.S18L | Q8TBB0 | protein_coding | deleterious(0.01) | possibly_damaging(0.881) | TCGA-B5-A0JY-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicin | SD | |
THAP6 | SNV | Missense_Mutation | rs370307359 | c.188C>T | p.Ser63Leu | p.S63L | Q8TBB0 | protein_coding | deleterious(0) | probably_damaging(0.979) | TCGA-B5-A1MR-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
THAP6 | SNV | Missense_Mutation | novel | c.137N>G | p.Asp46Gly | p.D46G | Q8TBB0 | protein_coding | tolerated(0.24) | probably_damaging(0.933) | TCGA-B5-A3FA-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
THAP6 | SNV | Missense_Mutation | novel | c.468N>A | p.Asp156Glu | p.D156E | Q8TBB0 | protein_coding | tolerated(0.22) | probably_damaging(0.967) | TCGA-DI-A1BU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | paclitaxel | SD |
THAP6 | SNV | Missense_Mutation | novel | c.569N>C | p.Leu190Ser | p.L190S | Q8TBB0 | protein_coding | deleterious(0) | probably_damaging(0.991) | TCGA-EO-A22R-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
THAP6 | SNV | Missense_Mutation | novel | c.562N>G | p.Arg188Gly | p.R188G | Q8TBB0 | protein_coding | tolerated(0.24) | benign(0.067) | TCGA-EY-A2OP-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
THAP6 | SNV | Missense_Mutation | novel | c.629N>G | p.Asp210Gly | p.D210G | Q8TBB0 | protein_coding | deleterious_low_confidence(0.03) | benign(0.014) | TCGA-SL-A6JA-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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