![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: THAP3 |
Gene summary for THAP3 |
![]() |
Gene information | Species | Human | Gene symbol | THAP3 | Gene ID | 90326 |
Gene name | THAP domain containing 3 | |
Gene Alias | THAP3 | |
Cytomap | 1p36.31 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q8WTV1 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
90326 | THAP3 | LZE4T | Human | Esophagus | ESCC | 9.11e-03 | 1.30e-01 | 0.0811 |
90326 | THAP3 | LZE7T | Human | Esophagus | ESCC | 4.91e-03 | 1.92e-01 | 0.0667 |
90326 | THAP3 | LZE24T | Human | Esophagus | ESCC | 1.55e-02 | 9.92e-02 | 0.0596 |
90326 | THAP3 | P1T-E | Human | Esophagus | ESCC | 9.28e-03 | 2.56e-01 | 0.0875 |
90326 | THAP3 | P2T-E | Human | Esophagus | ESCC | 4.52e-16 | 3.04e-01 | 0.1177 |
90326 | THAP3 | P4T-E | Human | Esophagus | ESCC | 1.16e-14 | 3.12e-01 | 0.1323 |
90326 | THAP3 | P5T-E | Human | Esophagus | ESCC | 7.32e-17 | 3.09e-01 | 0.1327 |
90326 | THAP3 | P8T-E | Human | Esophagus | ESCC | 6.72e-06 | 1.53e-01 | 0.0889 |
90326 | THAP3 | P9T-E | Human | Esophagus | ESCC | 8.60e-04 | 1.27e-01 | 0.1131 |
90326 | THAP3 | P10T-E | Human | Esophagus | ESCC | 4.94e-20 | 3.54e-01 | 0.116 |
90326 | THAP3 | P11T-E | Human | Esophagus | ESCC | 1.07e-10 | 3.80e-01 | 0.1426 |
90326 | THAP3 | P12T-E | Human | Esophagus | ESCC | 2.48e-15 | 2.69e-01 | 0.1122 |
90326 | THAP3 | P15T-E | Human | Esophagus | ESCC | 6.22e-10 | 2.41e-01 | 0.1149 |
90326 | THAP3 | P16T-E | Human | Esophagus | ESCC | 9.05e-14 | 2.21e-01 | 0.1153 |
90326 | THAP3 | P17T-E | Human | Esophagus | ESCC | 8.81e-04 | 2.32e-01 | 0.1278 |
90326 | THAP3 | P19T-E | Human | Esophagus | ESCC | 2.09e-06 | 4.41e-01 | 0.1662 |
90326 | THAP3 | P20T-E | Human | Esophagus | ESCC | 4.23e-19 | 4.26e-01 | 0.1124 |
90326 | THAP3 | P21T-E | Human | Esophagus | ESCC | 1.16e-16 | 2.66e-01 | 0.1617 |
90326 | THAP3 | P22T-E | Human | Esophagus | ESCC | 4.14e-09 | 1.84e-01 | 0.1236 |
90326 | THAP3 | P23T-E | Human | Esophagus | ESCC | 9.47e-12 | 2.95e-01 | 0.108 |
Page: 1 2 3 |
![]() |
Tissue | Expression Dynamics | Abbreviation |
Esophagus | ![]() | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias | ||
LGIN: Low-grade intraepithelial neoplasias |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
THAP3 | SNV | Missense_Mutation | novel | c.172N>T | p.His58Tyr | p.H58Y | Q8WTV1 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-A8-A0A1-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | SD |
THAP3 | SNV | Missense_Mutation | c.209G>A | p.Arg70His | p.R70H | Q8WTV1 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
THAP3 | SNV | Missense_Mutation | novel | c.621N>T | p.Gln207His | p.Q207H | Q8WTV1 | protein_coding | deleterious(0) | benign(0.041) | TCGA-C5-A2LT-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | SD |
THAP3 | SNV | Missense_Mutation | c.179N>A | p.Arg60Gln | p.R60Q | Q8WTV1 | protein_coding | tolerated(0.19) | benign(0.353) | TCGA-DR-A0ZM-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unspecific | Cisplatin | SD | |
THAP3 | SNV | Missense_Mutation | c.695G>A | p.Arg232Lys | p.R232K | Q8WTV1 | protein_coding | tolerated(0.36) | benign(0.05) | TCGA-MU-A51Y-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
THAP3 | SNV | Missense_Mutation | rs774544046 | c.656N>A | p.Arg219His | p.R219H | Q8WTV1 | protein_coding | tolerated(0.08) | possibly_damaging(0.683) | TCGA-QG-A5Z2-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
THAP3 | deletion | In_Frame_Del | c.502_504delNNN | p.Arg169del | p.R169del | Q8WTV1 | protein_coding | TCGA-AA-3811-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD | |||
THAP3 | SNV | Missense_Mutation | novel | c.157N>A | p.Val53Ile | p.V53I | Q8WTV1 | protein_coding | deleterious(0.02) | probably_damaging(0.923) | TCGA-A5-A7WJ-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
THAP3 | SNV | Missense_Mutation | c.286G>A | p.Asp96Asn | p.D96N | Q8WTV1 | protein_coding | tolerated(0.05) | benign(0.003) | TCGA-B5-A11E-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
THAP3 | SNV | Missense_Mutation | novel | c.200N>A | p.Phe67Tyr | p.F67Y | Q8WTV1 | protein_coding | tolerated(0.1) | possibly_damaging(0.907) | TCGA-B5-A1MR-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
Page: 1 2 3 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |