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Gene: TGOLN2 |
Gene summary for TGOLN2 |
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Gene information | Species | Human | Gene symbol | TGOLN2 | Gene ID | 10618 |
Gene name | trans-golgi network protein 2 | |
Gene Alias | TGN38 | |
Cytomap | 2p11.2 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | O43493 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
10618 | TGOLN2 | HTA11_2487_2000001011 | Human | Colorectum | SER | 2.24e-12 | 7.44e-01 | -0.1808 |
10618 | TGOLN2 | HTA11_1938_2000001011 | Human | Colorectum | AD | 4.45e-11 | 6.90e-01 | -0.0811 |
10618 | TGOLN2 | HTA11_78_2000001011 | Human | Colorectum | AD | 1.71e-11 | 6.81e-01 | -0.1088 |
10618 | TGOLN2 | HTA11_347_2000001011 | Human | Colorectum | AD | 1.02e-36 | 9.91e-01 | -0.1954 |
10618 | TGOLN2 | HTA11_411_2000001011 | Human | Colorectum | SER | 9.22e-06 | 1.08e+00 | -0.2602 |
10618 | TGOLN2 | HTA11_2112_2000001011 | Human | Colorectum | SER | 1.93e-02 | 7.82e-01 | -0.2196 |
10618 | TGOLN2 | HTA11_3361_2000001011 | Human | Colorectum | AD | 2.44e-02 | 4.69e-01 | -0.1207 |
10618 | TGOLN2 | HTA11_83_2000001011 | Human | Colorectum | SER | 4.56e-09 | 7.36e-01 | -0.1526 |
10618 | TGOLN2 | HTA11_696_2000001011 | Human | Colorectum | AD | 9.55e-25 | 7.44e-01 | -0.1464 |
10618 | TGOLN2 | HTA11_866_2000001011 | Human | Colorectum | AD | 4.15e-10 | 5.12e-01 | -0.1001 |
10618 | TGOLN2 | HTA11_1391_2000001011 | Human | Colorectum | AD | 4.12e-09 | 6.64e-01 | -0.059 |
10618 | TGOLN2 | HTA11_2992_2000001011 | Human | Colorectum | SER | 5.22e-04 | 6.16e-01 | -0.1706 |
10618 | TGOLN2 | HTA11_5212_2000001011 | Human | Colorectum | AD | 3.19e-09 | 9.48e-01 | -0.2061 |
10618 | TGOLN2 | HTA11_546_2000001011 | Human | Colorectum | AD | 6.38e-05 | 5.98e-01 | -0.0842 |
10618 | TGOLN2 | HTA11_7862_2000001011 | Human | Colorectum | AD | 9.96e-04 | 4.72e-01 | -0.0179 |
10618 | TGOLN2 | HTA11_866_3004761011 | Human | Colorectum | AD | 5.36e-07 | 4.19e-01 | 0.096 |
10618 | TGOLN2 | HTA11_7663_2000001011 | Human | Colorectum | SER | 7.64e-04 | 7.51e-01 | 0.0131 |
10618 | TGOLN2 | HTA11_6801_2000001011 | Human | Colorectum | SER | 3.01e-04 | 5.94e-01 | 0.0171 |
10618 | TGOLN2 | HTA11_10711_2000001011 | Human | Colorectum | AD | 1.33e-04 | 4.86e-01 | 0.0338 |
10618 | TGOLN2 | HTA11_7696_3000711011 | Human | Colorectum | AD | 8.46e-05 | 4.10e-01 | 0.0674 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TGOLN2 | SNV | Missense_Mutation | novel | c.72N>C | p.Glu24Asp | p.E24D | O43493 | protein_coding | tolerated(0.46) | benign(0.01) | TCGA-A8-A08H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TGOLN2 | SNV | Missense_Mutation | novel | c.391C>G | p.Gln131Glu | p.Q131E | O43493 | protein_coding | deleterious(0.01) | benign(0.005) | TCGA-LL-A5YO-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxotere | CR |
TGOLN2 | insertion | Frame_Shift_Ins | novel | c.971_972insGCCTC | p.Glu325ProfsTer68 | p.E325Pfs*68 | O43493 | protein_coding | TCGA-A2-A0CM-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | PD | ||
TGOLN2 | insertion | Frame_Shift_Ins | novel | c.970_971insC | p.Lys324ThrfsTer4 | p.K324Tfs*4 | O43493 | protein_coding | TCGA-A2-A0CM-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | PD | ||
TGOLN2 | insertion | Frame_Shift_Ins | novel | c.73_74insTTGTTCTTCTGTGTTCCCTTTATTTATGCTGG | p.Ser25IlefsTer33 | p.S25Ifs*33 | O43493 | protein_coding | TCGA-A8-A08H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
TGOLN2 | insertion | Nonsense_Mutation | novel | c.890_891insGGATTCTGATGTAATTAGGCTCTGTCTTTCTTAAAATGGTTAT | p.Ser298AspfsTer11 | p.S298Dfs*11 | O43493 | protein_coding | TCGA-AO-A0JM-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD | ||
TGOLN2 | SNV | Missense_Mutation | novel | c.469G>C | p.Glu157Gln | p.E157Q | O43493 | protein_coding | tolerated(0.63) | benign(0.068) | TCGA-HM-A4S6-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Chemotherapy | cisplatin | CR |
TGOLN2 | SNV | Missense_Mutation | c.1030N>C | p.Glu344Gln | p.E344Q | O43493 | protein_coding | deleterious(0.02) | probably_damaging(0.919) | TCGA-Q1-A73O-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
TGOLN2 | SNV | Missense_Mutation | c.745C>A | p.Pro249Thr | p.P249T | O43493 | protein_coding | tolerated(0.06) | benign(0.038) | TCGA-AA-3833-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
TGOLN2 | SNV | Missense_Mutation | c.211N>T | p.Ser71Cys | p.S71C | O43493 | protein_coding | deleterious(0.05) | benign(0.325) | TCGA-AZ-5407-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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