Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

Home

Download

Statistics

Help

Contact
Center for Computational Systems Medicine
leaf

Gene summary

leaf

Malignant transformation analysis

leaf

Malignant transformation related pathway analysis

leaf

Cell-cell communication analysis

leaf

Single-cell gene regulatory network inference analysis

leaf

Somatic mutation of malignant transformation related genes

leaf

Related drugs of malignant transformation related genes

Gene: TGFBR3

Gene summary for TGFBR3

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

TGFBR3

Gene ID

7049

Gene nametransforming growth factor beta receptor 3
Gene AliasBGCAN
Cytomap1p22.1
Gene Typeprotein-coding
GO ID

GO:0001568

UniProtAcc

A0A0A8KWK3


Top

Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
7049TGFBR3HTA11_99999970781_79442HumanColorectumMSS2.48e-114.28e-010.294
7049TGFBR3HTA11_99999965062_69753HumanColorectumMSI-H1.47e-061.40e+000.3487
7049TGFBR3HTA11_99999965104_69814HumanColorectumMSS2.61e-055.21e-010.281
7049TGFBR3HTA11_99999971662_82457HumanColorectumMSS3.17e-208.14e-010.3859
7049TGFBR3A002-C-010HumanColorectumFAP2.94e-073.51e-010.242
7049TGFBR3A002-C-021HumanColorectumFAP5.95e-124.77e-010.1171
7049TGFBR3CRC-3-11773HumanColorectumCRC8.42e-075.28e-010.2564
7049TGFBR3S41HumanLiverCirrhotic1.36e-026.64e-01-0.0343
7049TGFBR3HCC1_MengHumanLiverHCC1.19e-02-1.57e-010.0246
7049TGFBR3HCC2_MengHumanLiverHCC2.97e-07-5.08e-020.0107
7049TGFBR3S014HumanLiverHCC9.09e-189.80e-010.2254
7049TGFBR3S015HumanLiverHCC3.01e-141.11e+000.2375
7049TGFBR3S016HumanLiverHCC9.83e-241.12e+000.2243
Page: 1 

check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
Colorectum (GSE201348)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.FAP: Familial adenomatous polyposis
CRC: Colorectal cancer
Colorectum (HTA11)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AD: Adenomas
SER: Sessile serrated lesions
MSI-H: Microsatellite-high colorectal cancer
MSS: Microsatellite stable colorectal cancer
LiverThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.HCC: Hepatocellular carcinoma
NAFLD: Non-alcoholic fatty liver disease
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

Top

Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
Page: 1 2 3 4 5 6 7 8 9 

check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:00487322ColorectumMSSgland development143/3467436/187233.85e-138.01e-11143
GO:00510982ColorectumMSSregulation of binding113/3467363/187233.55e-092.41e-07113
GO:00341012ColorectumMSSerythrocyte homeostasis49/3467129/187231.58e-077.19e-0649
GO:00300992ColorectumMSSmyeloid cell differentiation110/3467381/187234.48e-071.75e-05110
GO:00022622ColorectumMSSmyeloid cell homeostasis55/3467157/187236.35e-072.34e-0555
GO:00488722ColorectumMSShomeostasis of number of cells82/3467272/187232.02e-066.28e-0582
GO:00302182ColorectumMSSerythrocyte differentiation44/3467120/187232.03e-066.28e-0544
GO:00610082ColorectumMSShepaticobiliary system development51/3467150/187234.33e-061.23e-0451
GO:00018892ColorectumMSSliver development50/3467147/187235.28e-061.44e-0450
GO:00433932ColorectumMSSregulation of protein binding62/3467196/187236.44e-061.69e-0462
GO:19016542ColorectumMSSresponse to ketone58/3467194/187237.70e-051.28e-0358
GO:00434342ColorectumMSSresponse to peptide hormone104/3467414/187234.58e-045.43e-03104
GO:00506731ColorectumMSSepithelial cell proliferation108/3467437/187236.76e-047.30e-03108
GO:00486381ColorectumMSSregulation of developmental growth84/3467330/187231.01e-031.01e-0284
GO:00486391ColorectumMSSpositive regulation of developmental growth49/3467174/187231.17e-031.13e-0249
GO:00459272ColorectumMSSpositive regulation of growth68/3467259/187231.24e-031.19e-0268
GO:00973051ColorectumMSSresponse to alcohol66/3467253/187231.73e-031.54e-0266
GO:00311001ColorectumMSSanimal organ regeneration25/346776/187231.91e-031.66e-0225
GO:00704822ColorectumMSSresponse to oxygen levels85/3467347/187233.08e-032.34e-0285
GO:00071781ColorectumMSStransmembrane receptor protein serine/threonine kinase signaling pathway86/3467355/187234.04e-032.95e-0286
Page: 1 2 3 4 5 6 7 8 9 

check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
Page: 1 

Top

Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
Page: 1 

Top

Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
Page: 1 

Top

Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
TGFBR3SNVMissense_Mutationnovelc.448N>Ap.Glu150Lysp.E150KQ03167protein_codingtolerated(0.13)benign(0.085)TCGA-A8-A06Q-01Breastbreast invasive carcinomaFemale<65III/IVUnknownUnknownSD
TGFBR3SNVMissense_Mutationnovelc.1621N>Cp.Glu541Glnp.E541QQ03167protein_codingtolerated(0.13)probably_damaging(0.971)TCGA-A8-A07J-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapy5-fluorouracilCR
TGFBR3SNVMissense_Mutationrs776276219c.1100N>Cp.Val367Alap.V367AQ03167protein_codingtolerated(0.71)benign(0.055)TCGA-AN-A0AK-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownSD
TGFBR3SNVMissense_Mutationc.2429N>Ap.Ser810Tyrp.S810YQ03167protein_codingdeleterious(0)probably_damaging(0.99)TCGA-AO-A03V-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapyfluorouracilSD
TGFBR3SNVMissense_Mutationc.293N>Cp.Lys98Thrp.K98TQ03167protein_codingdeleterious(0)probably_damaging(0.999)TCGA-AO-A128-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapydoxorubicinSD
TGFBR3SNVMissense_Mutationnovelc.67N>Cp.Glu23Glnp.E23QQ03167protein_codingtolerated(0.1)benign(0.412)TCGA-C8-A12P-01Breastbreast invasive carcinomaFemale<65I/IIUnknownUnknownSD
TGFBR3SNVMissense_Mutationc.947T>Cp.Ile316Thrp.I316TQ03167protein_codingtolerated(0.75)benign(0.055)TCGA-EW-A2FS-01Breastbreast invasive carcinomaFemale<65I/IIHormone TherapygoserelinSD
TGFBR3insertionFrame_Shift_Insnovelc.1618_1619insCCCTGCACAGTCCCCTTAGCCCCCAGCAGGGCAGCCAAp.Tyr540SerfsTer51p.Y540Sfs*51Q03167protein_codingTCGA-A8-A07J-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapy5-fluorouracilCR
TGFBR3insertionFrame_Shift_Insnovelc.2012_2013insATTAGATTCAAATAp.Lys672LeufsTer41p.K672Lfs*41Q03167protein_codingTCGA-AO-A128-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapydoxorubicinSD
TGFBR3SNVMissense_Mutationrs373781090c.2240C>Tp.Thr747Metp.T747MQ03167protein_codingdeleterious(0.03)probably_damaging(0.944)TCGA-2W-A8YY-01Cervixcervical & endocervical cancerFemale<65I/IIChemotherapycisplatinCR
Page: 1 2 3 4 5 6 7 8 9 10 11 

Top

Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
7049TGFBR3CELL SURFACE, EXTERNAL SIDE OF PLASMA MEMBRANE, DRUGGABLE GENOMECYTOKINES16634800
7049TGFBR3CELL SURFACE, EXTERNAL SIDE OF PLASMA MEMBRANE, DRUGGABLE GENOMEDEXAMETHASONEDEXAMETHASONE8143777
7049TGFBR3CELL SURFACE, EXTERNAL SIDE OF PLASMA MEMBRANE, DRUGGABLE GENOMERANTES14637022
7049TGFBR3CELL SURFACE, EXTERNAL SIDE OF PLASMA MEMBRANE, DRUGGABLE GENOMEBFGF1556106
7049TGFBR3CELL SURFACE, EXTERNAL SIDE OF PLASMA MEMBRANE, DRUGGABLE GENOMEantidepressants23092981
7049TGFBR3CELL SURFACE, EXTERNAL SIDE OF PLASMA MEMBRANE, DRUGGABLE GENOMEGM-CSFREGRAMOSTIM12471017
7049TGFBR3CELL SURFACE, EXTERNAL SIDE OF PLASMA MEMBRANE, DRUGGABLE GENOMETG-C
7049TGFBR3CELL SURFACE, EXTERNAL SIDE OF PLASMA MEMBRANE, DRUGGABLE GENOMETGF-BETA 21744125
7049TGFBR3CELL SURFACE, EXTERNAL SIDE OF PLASMA MEMBRANE, DRUGGABLE GENOMERETINOIC ACID8143777
Page: 1