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Gene: TFEC |
Gene summary for TFEC |
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Gene information | Species | Human | Gene symbol | TFEC | Gene ID | 22797 |
Gene name | transcription factor EC | |
Gene Alias | TCFEC | |
Cytomap | 7q31.2 | |
Gene Type | protein-coding | GO ID | GO:0000122 | UniProtAcc | O14948 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
22797 | TFEC | Pt14.d | Human | Liver | HCC | 4.03e-02 | 1.54e-01 | 0.0143 |
22797 | TFEC | S027 | Human | Liver | HCC | 2.78e-14 | 1.01e+00 | 0.2446 |
22797 | TFEC | S028 | Human | Liver | HCC | 6.14e-17 | 8.54e-01 | 0.2503 |
22797 | TFEC | S029 | Human | Liver | HCC | 2.50e-18 | 5.76e-01 | 0.2581 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:003460512 | Liver | HCC | cellular response to heat | 53/7958 | 69/18723 | 6.62e-09 | 1.70e-07 | 53 |
GO:000940811 | Liver | HCC | response to heat | 76/7958 | 110/18723 | 1.48e-08 | 3.58e-07 | 76 |
GO:000926611 | Liver | HCC | response to temperature stimulus | 101/7958 | 178/18723 | 8.55e-05 | 7.48e-04 | 101 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TFEC | SNV | Missense_Mutation | c.697C>A | p.Pro233Thr | p.P233T | O14948 | protein_coding | tolerated(0.1) | probably_damaging(1) | TCGA-A8-A08R-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
TFEC | SNV | Missense_Mutation | novel | c.245N>G | p.Ser82Cys | p.S82C | O14948 | protein_coding | tolerated(0.37) | benign(0.338) | TCGA-D8-A27V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD |
TFEC | SNV | Missense_Mutation | rs764342019 | c.200N>G | p.Asp67Gly | p.D67G | O14948 | protein_coding | deleterious(0) | benign(0.283) | TCGA-E2-A14S-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | cytoxan | SD |
TFEC | SNV | Missense_Mutation | c.844T>C | p.Phe282Leu | p.F282L | O14948 | protein_coding | tolerated(0.14) | probably_damaging(0.994) | TCGA-FU-A3HZ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
TFEC | SNV | Missense_Mutation | c.24N>G | p.Ile8Met | p.I8M | O14948 | protein_coding | tolerated_low_confidence(0.11) | benign(0.047) | TCGA-IR-A3LH-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
TFEC | SNV | Missense_Mutation | rs367653280 | c.263N>T | p.Arg88Ile | p.R88I | O14948 | protein_coding | tolerated(0.06) | benign(0.037) | TCGA-AA-3510-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
TFEC | SNV | Missense_Mutation | novel | c.853N>A | p.Pro285Thr | p.P285T | O14948 | protein_coding | tolerated(0.05) | probably_damaging(1) | TCGA-AA-3715-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
TFEC | SNV | Missense_Mutation | novel | c.151C>A | p.Pro51Thr | p.P51T | protein_coding | deleterious(0.01) | benign(0.381) | TCGA-AU-6004-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
TFEC | SNV | Missense_Mutation | c.432N>A | p.His144Gln | p.H144Q | O14948 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AY-A54L-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
TFEC | SNV | Missense_Mutation | novel | c.464N>C | p.Ile155Thr | p.I155T | O14948 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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