Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: TFDP2

Gene summary for TFDP2

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

TFDP2

Gene ID

7029

Gene nametranscription factor Dp-2
Gene AliasDP2
Cytomap3q23
Gene Typeprotein-coding
GO ID

GO:0006139

UniProtAcc

Q14188


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
7029TFDP2CA_HPV_1HumanCervixCC4.96e-07-1.98e-010.0264
7029TFDP2CCI_1HumanCervixCC3.02e-078.94e-010.528
7029TFDP2CCI_2HumanCervixCC3.84e-051.51e+000.5249
7029TFDP2CCI_3HumanCervixCC1.14e-171.35e+000.516
7029TFDP2HTA11_347_2000001011HumanColorectumAD3.13e-065.40e-01-0.1954
7029TFDP2A015-C-203HumanColorectumFAP2.66e-20-2.69e-01-0.1294
7029TFDP2A015-C-204HumanColorectumFAP1.34e-03-2.38e-01-0.0228
7029TFDP2A014-C-040HumanColorectumFAP7.75e-03-3.09e-01-0.1184
7029TFDP2A002-C-201HumanColorectumFAP3.29e-09-2.26e-010.0324
7029TFDP2A001-C-119HumanColorectumFAP8.42e-03-1.35e-01-0.1557
7029TFDP2A001-C-108HumanColorectumFAP4.15e-084.55e-02-0.0272
7029TFDP2A002-C-205HumanColorectumFAP1.56e-17-2.59e-01-0.1236
7029TFDP2A015-C-006HumanColorectumFAP3.86e-13-4.01e-01-0.0994
7029TFDP2A015-C-106HumanColorectumFAP6.70e-04-8.11e-02-0.0511
7029TFDP2A002-C-114HumanColorectumFAP2.13e-15-3.99e-01-0.1561
7029TFDP2A015-C-104HumanColorectumFAP3.97e-22-3.48e-01-0.1899
7029TFDP2A001-C-014HumanColorectumFAP4.82e-05-1.78e-010.0135
7029TFDP2A002-C-016HumanColorectumFAP3.30e-15-2.66e-010.0521
7029TFDP2A015-C-002HumanColorectumFAP1.85e-10-3.67e-01-0.0763
7029TFDP2A001-C-203HumanColorectumFAP4.55e-06-3.45e-02-0.0481
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
CervixThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.CC: Cervix cancer
HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions
N_HPV: HPV-infected normal cervix
Colorectum (GSE201348)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.FAP: Familial adenomatous polyposis
CRC: Colorectal cancer
Colorectum (HTA11)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AD: Adenomas
SER: Sessile serrated lesions
MSI-H: Microsatellite-high colorectal cancer
MSS: Microsatellite stable colorectal cancer
EsophagusThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ESCC: Esophageal squamous cell carcinoma
HGIN: High-grade intraepithelial neoplasias
LGIN: Low-grade intraepithelial neoplasias
LiverThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.HCC: Hepatocellular carcinoma
NAFLD: Non-alcoholic fatty liver disease
LungThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AAH: Atypical adenomatous hyperplasia
AIS: Adenocarcinoma in situ
IAC: Invasive lung adenocarcinoma
MIA: Minimally invasive adenocarcinoma
Oral CavityThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.EOLP: Erosive Oral lichen planus
LP: leukoplakia
NEOLP: Non-erosive oral lichen planus
OSCC: Oral squamous cell carcinoma
ProstateThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.BPH: Benign Prostatic Hyperplasia
SkinThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AK: Actinic keratosis
cSCC: Cutaneous squamous cell carcinoma
SCCIS:squamous cell carcinoma in situ
ThyroidThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ATC: Anaplastic thyroid cancer
HT: Hashimoto's thyroiditis
PTC: Papillary thyroid cancer
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
hsa041106CervixCCCell cycle36/1267157/84654.94e-031.67e-029.86e-0336
hsa0411013CervixCCCell cycle36/1267157/84654.94e-031.67e-029.86e-0336
hsa04110ColorectumFAPCell cycle37/1404157/84651.44e-024.77e-022.90e-0237
hsa041101ColorectumFAPCell cycle37/1404157/84651.44e-024.77e-022.90e-0237
hsa041109EsophagusHGINCell cycle38/1383157/84656.70e-034.37e-023.47e-0238
hsa0411016EsophagusHGINCell cycle38/1383157/84656.70e-034.37e-023.47e-0238
hsa0411023EsophagusESCCCell cycle126/4205157/84651.34e-155.60e-142.87e-14126
hsa0411033EsophagusESCCCell cycle126/4205157/84651.34e-155.60e-142.87e-14126
hsa041104LiverCirrhoticCell cycle61/2530157/84659.53e-033.21e-021.98e-0261
hsa0411011LiverCirrhoticCell cycle61/2530157/84659.53e-033.21e-021.98e-0261
hsa041102LiverHCCCell cycle106/4020157/84652.54e-073.04e-061.69e-06106
hsa041103LiverHCCCell cycle106/4020157/84652.54e-073.04e-061.69e-06106
hsa041105LungIACCell cycle30/1053157/84651.03e-023.83e-022.54e-0230
hsa0411012LungIACCell cycle30/1053157/84651.03e-023.83e-022.54e-0230
hsa041108Oral cavityOSCCCell cycle118/3704157/84657.15e-162.66e-141.35e-14118
hsa0411015Oral cavityOSCCCell cycle118/3704157/84657.15e-162.66e-141.35e-14118
hsa0411022Oral cavityLPCell cycle70/2418157/84651.17e-058.27e-055.33e-0570
hsa0411032Oral cavityLPCell cycle70/2418157/84651.17e-058.27e-055.33e-0570
hsa041107ProstateBPHCell cycle49/1718157/84657.39e-043.59e-032.22e-0349
hsa0411014ProstateBPHCell cycle49/1718157/84657.39e-043.59e-032.22e-0349
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
TFDP2STMBreastHealthyAL354733.3,CADM1,SOX4, etc.1.57e-01The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
TFDP2MSC.ADIPOCervixCCHLTF,SLC25A36,ACAP2, etc.2.53e-01The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
TFDP2MSC.MVACervixCCHLTF,SLC25A36,ACAP2, etc.1.85e-01The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
TFDP2STMEsophagusADJSLC25A36,U2SURP,ATP1B3, etc.4.54e-01The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
TFDP2CD8TEXINTEsophagusADJPPM1K,LRRFIP2,APOC1, etc.2.45e-01The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
TFDP2GDTOral cavityEOLPTGFBR3,IL18RAP,GALNT11, etc.1.31e-01The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
TFDP2INMONOral cavityHealthyTGFBR3,IL18RAP,GALNT11, etc.4.54e-02The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
TFDP2INMONOral cavityLPTGFBR3,IL18RAP,GALNT11, etc.9.49e-02The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
TFDP2MYOFIBOral cavityLPCCDC138,RMDN2-AS1,ZFPM2, etc.7.38e-02The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
TFDP2MYOFIBOral cavityOSCCCCDC138,RMDN2-AS1,ZFPM2, etc.1.76e-01The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
TFDP2SNVMissense_Mutationnovelc.1334N>Ap.Pro445Glnp.P445QQ14188protein_codingdeleterious_low_confidence(0)probably_damaging(0.994)TCGA-A7-A0DB-01Breastbreast invasive carcinomaFemale<65I/IIHormone TherapyarimidexSD
TFDP2SNVMissense_Mutationrs776411928c.1010N>Tp.Ala337Valp.A337VQ14188protein_codingtolerated(0.08)probably_damaging(0.997)TCGA-AN-A0AK-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownSD
TFDP2SNVMissense_Mutationc.889N>Cp.Glu297Glnp.E297QQ14188protein_codingdeleterious(0)probably_damaging(0.996)TCGA-D8-A1X9-01Breastbreast invasive carcinomaFemale>=65I/IIChemotherapyadriamycin+cyclophosphamideSD
TFDP2insertionFrame_Shift_Insnovelc.1274_1275insACTAATCCAATATTTAGTGTTTCACAGAAACACTAGAAAACp.Thr426LeufsTer59p.T426Lfs*59Q14188protein_codingTCGA-A8-A07U-01Breastbreast invasive carcinomaFemale>=65III/IVChemotherapy5-fluorouracilSD
TFDP2deletionFrame_Shift_Delc.1203_1228delNNNNNNNNNNNNNNNNNNNNNNNNNNp.Gly402ProfsTer22p.G402Pfs*22Q14188protein_codingTCGA-AN-A041-01Breastbreast invasive carcinomaFemale<65I/IIUnknownUnknownSD
TFDP2SNVMissense_Mutationnovelc.7G>Ap.Ala3Thrp.A3TQ14188protein_codingdeleterious(0.03)benign(0)TCGA-2W-A8YY-01Cervixcervical & endocervical cancerFemale<65I/IIChemotherapycisplatinCR
TFDP2SNVMissense_Mutationnovelc.514N>Ap.Asp172Asnp.D172NQ14188protein_codingtolerated(0.09)probably_damaging(0.955)TCGA-MA-AA3Y-01Cervixcervical & endocervical cancerFemale<65I/IIUnknownUnknownSD
TFDP2SNVMissense_Mutationc.151N>Gp.Leu51Valp.L51VQ14188protein_codingdeleterious(0.05)possibly_damaging(0.482)TCGA-A6-3809-01Colorectumcolon adenocarcinomaFemale>=65I/IIUnknownUnknownSD
TFDP2SNVMissense_Mutationnovelc.878G>Tp.Ser293Ilep.S293IQ14188protein_codingdeleterious(0)probably_damaging(0.999)TCGA-AA-3950-01Colorectumcolon adenocarcinomaFemale>=65I/IIUnknownUnknownSD
TFDP2SNVMissense_Mutationc.545G>Ap.Arg182Glnp.R182QQ14188protein_codingdeleterious(0)probably_damaging(0.998)TCGA-AA-A010-01Colorectumcolon adenocarcinomaFemale<65I/IIChemotherapyfolinicCR
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
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