Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: TFCP2

Gene summary for TFCP2

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

TFCP2

Gene ID

7024

Gene nametranscription factor CP2
Gene AliasLBP1C
Cytomap12q13.12-q13.13
Gene Typeprotein-coding
GO ID

GO:0006139

UniProtAcc

Q12800


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
7024TFCP2CCI_1HumanCervixCC2.03e-087.82e-010.528
7024TFCP2CCI_2HumanCervixCC4.85e-078.09e-010.5249
7024TFCP2CCI_3HumanCervixCC2.46e-138.04e-010.516
7024TFCP2HTA11_3410_2000001011HumanColorectumAD2.20e-06-2.58e-010.0155
7024TFCP2HTA11_5212_2000001011HumanColorectumAD3.05e-02-5.33e-01-0.2061
7024TFCP2F007HumanColorectumFAP4.07e-03-2.55e-010.1176
7024TFCP2A001-C-207HumanColorectumFAP9.39e-05-2.10e-010.1278
7024TFCP2A015-C-203HumanColorectumFAP8.80e-30-4.77e-01-0.1294
7024TFCP2A015-C-204HumanColorectumFAP1.69e-07-2.96e-01-0.0228
7024TFCP2A014-C-040HumanColorectumFAP5.56e-06-4.47e-01-0.1184
7024TFCP2A002-C-201HumanColorectumFAP5.54e-16-3.89e-010.0324
7024TFCP2A002-C-203HumanColorectumFAP2.06e-03-8.56e-020.2786
7024TFCP2A001-C-119HumanColorectumFAP2.02e-06-2.69e-01-0.1557
7024TFCP2A001-C-108HumanColorectumFAP3.74e-16-2.95e-01-0.0272
7024TFCP2A002-C-205HumanColorectumFAP5.75e-25-4.60e-01-0.1236
7024TFCP2A001-C-104HumanColorectumFAP3.52e-04-1.45e-010.0184
7024TFCP2A015-C-005HumanColorectumFAP5.32e-05-2.55e-01-0.0336
7024TFCP2A015-C-006HumanColorectumFAP1.19e-14-2.65e-01-0.0994
7024TFCP2A015-C-106HumanColorectumFAP7.41e-09-2.22e-01-0.0511
7024TFCP2A002-C-114HumanColorectumFAP7.78e-21-4.51e-01-0.1561
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
CervixThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.CC: Cervix cancer
HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions
N_HPV: HPV-infected normal cervix
Colorectum (GSE201348)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.FAP: Familial adenomatous polyposis
CRC: Colorectal cancer
Colorectum (HTA11)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AD: Adenomas
SER: Sessile serrated lesions
MSI-H: Microsatellite-high colorectal cancer
MSS: Microsatellite stable colorectal cancer
EndometriumThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AEH: Atypical endometrial hyperplasia
EEC: Endometrioid Cancer
EsophagusThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ESCC: Esophageal squamous cell carcinoma
HGIN: High-grade intraepithelial neoplasias
LGIN: Low-grade intraepithelial neoplasias
LiverThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.HCC: Hepatocellular carcinoma
NAFLD: Non-alcoholic fatty liver disease
LungThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AAH: Atypical adenomatous hyperplasia
AIS: Adenocarcinoma in situ
IAC: Invasive lung adenocarcinoma
MIA: Minimally invasive adenocarcinoma
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:0002064ColorectumADepithelial cell development89/3918220/187232.98e-113.52e-0989
GO:0048732ColorectumADgland development149/3918436/187236.07e-116.33e-09149
GO:0007568ColorectumADaging98/3918339/187232.77e-043.39e-0398
GO:0045927ColorectumADpositive regulation of growth77/3918259/187234.82e-045.27e-0377
GO:00487321ColorectumSERgland development112/2897436/187231.75e-081.28e-06112
GO:00020641ColorectumSERepithelial cell development64/2897220/187231.96e-071.10e-0564
GO:00459271ColorectumSERpositive regulation of growth56/2897259/187235.10e-033.91e-0256
GO:00487322ColorectumMSSgland development143/3467436/187233.85e-138.01e-11143
GO:00020642ColorectumMSSepithelial cell development81/3467220/187231.02e-101.06e-0881
GO:00075681ColorectumMSSaging90/3467339/187231.51e-042.19e-0390
GO:00459272ColorectumMSSpositive regulation of growth68/3467259/187231.24e-031.19e-0268
GO:00020644ColorectumFAPepithelial cell development62/2622220/187232.74e-082.54e-0662
GO:00487324ColorectumFAPgland development103/2622436/187233.61e-083.12e-06103
GO:00459273ColorectumFAPpositive regulation of growth66/2622259/187236.11e-073.05e-0566
GO:00075682ColorectumFAPaging69/2622339/187237.66e-048.12e-0369
GO:0021700ColorectumFAPdevelopmental maturation57/2622280/187232.08e-031.72e-0257
GO:0007028ColorectumFAPcytoplasm organization5/262210/187237.32e-034.38e-025
GO:00020645ColorectumCRCepithelial cell development55/2078220/187234.63e-091.16e-0655
GO:00487325ColorectumCRCgland development88/2078436/187231.62e-082.79e-0688
GO:00459274ColorectumCRCpositive regulation of growth51/2078259/187233.23e-058.27e-0451
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
TFCP2MSC.ADIPOCervixCCE2F5,NSMCE3,ALYREF, etc.2.02e-01The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
TFCP2DCColorectumADJKDM2B,PREX1,PDCD1LG2, etc.9.36e-02The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
TFCP2DCColorectumCRCKDM2B,PREX1,PDCD1LG2, etc.8.80e-02The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
TFCP2DCColorectumFAPKDM2B,PREX1,PDCD1LG2, etc.1.13e-01The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
TFCP2DCColorectumSERKDM2B,PREX1,PDCD1LG2, etc.8.13e-02The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
TFCP2LYMENDEsophagusESCCIRS2,TSLP,SLC5A3, etc.5.81e-02The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
TFCP2SMCEsophagusHealthyIRS2,TSLP,SLC5A3, etc.8.33e-02The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
TFCP2CD8TEREXLiverHealthyCD7,UHMK1,ETV5, etc.9.70e-03The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
TFCP2MMCLungHealthyF13A1,ATM,ADCY3, etc.2.23e-03The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
TFCP2cDCSkinAKLRRK1,TMCC3,NCKAP5, etc.4.96e-02The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
TFCP2SNVMissense_Mutationnovelc.543N>Tp.Lys181Asnp.K181NQ12800protein_codingdeleterious(0.02)possibly_damaging(0.735)TCGA-AN-A046-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownSD
TFCP2SNVMissense_Mutationnovelc.1441N>Ap.Glu481Lysp.E481KQ12800protein_codingdeleterious(0.01)benign(0.102)TCGA-D8-A73U-01Breastbreast invasive carcinomaFemale>=65I/IIHormone TherapytamoxiphenSD
TFCP2SNVMissense_Mutationc.794N>Tp.Tyr265Phep.Y265FQ12800protein_codingtolerated(0.07)benign(0.424)TCGA-EW-A1OY-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapydoxorubicinSD
TFCP2SNVMissense_Mutationnovelc.1129N>Tp.Leu377Phep.L377FQ12800protein_codingdeleterious(0.02)benign(0.32)TCGA-2W-A8YY-01Cervixcervical & endocervical cancerFemale<65I/IIChemotherapycisplatinCR
TFCP2SNVMissense_Mutationc.1365N>Gp.Ile455Metp.I455MQ12800protein_codingdeleterious(0)probably_damaging(0.98)TCGA-C5-A1BK-01Cervixcervical & endocervical cancerFemale<65I/IIUnknownUnknownSD
TFCP2SNVMissense_Mutationc.200T>Gp.Phe67Cysp.F67CQ12800protein_codingdeleterious(0)probably_damaging(0.967)TCGA-FU-A3HZ-01Cervixcervical & endocervical cancerFemale<65I/IIChemotherapycisplatinCR
TFCP2SNVMissense_Mutationnovelc.551N>Gp.Ser184Cysp.S184CQ12800protein_codingdeleterious(0.01)probably_damaging(0.95)TCGA-IR-A3LA-01Cervixcervical & endocervical cancerFemale<65I/IIChemotherapycisplatinCR
TFCP2SNVMissense_Mutationc.588N>Ap.Phe196Leup.F196LQ12800protein_codingdeleterious(0.02)probably_damaging(0.984)TCGA-IR-A3LI-01Cervixcervical & endocervical cancerFemale<65I/IIChemotherapycisplatinCR
TFCP2SNVMissense_Mutationnovelc.1117N>Cp.Asp373Hisp.D373HQ12800protein_codingdeleterious(0)probably_damaging(0.987)TCGA-VS-A958-01Cervixcervical & endocervical cancerFemale<65I/IIChemotherapycisplatinCR
TFCP2SNVMissense_Mutationnovelc.286N>Ap.Glu96Lysp.E96KQ12800protein_codingdeleterious(0)possibly_damaging(0.542)TCGA-VS-A958-01Cervixcervical & endocervical cancerFemale<65I/IIChemotherapycisplatinCR
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
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