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Gene: TENT4B |
Gene summary for TENT4B |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | TENT4B | Gene ID | 64282 |
| Gene name | terminal nucleotidyltransferase 4B | |
| Gene Alias | PAPD5 | |
| Cytomap | 16q12.1 | |
| Gene Type | protein-coding | GO ID | GO:0000288 | UniProtAcc | Q8NDF8 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 64282 | TENT4B | HTA11_3410_2000001011 | Human | Colorectum | AD | 1.09e-06 | -3.48e-01 | 0.0155 |
| 64282 | TENT4B | HTA11_99999970781_79442 | Human | Colorectum | MSS | 2.71e-26 | -5.12e-01 | 0.294 |
| 64282 | TENT4B | HTA11_99999965104_69814 | Human | Colorectum | MSS | 1.14e-10 | -5.12e-01 | 0.281 |
| 64282 | TENT4B | HTA11_99999971662_82457 | Human | Colorectum | MSS | 6.56e-26 | -5.12e-01 | 0.3859 |
| 64282 | TENT4B | HTA11_99999973899_84307 | Human | Colorectum | MSS | 5.60e-08 | -5.12e-01 | 0.2585 |
| 64282 | TENT4B | HTA11_99999974143_84620 | Human | Colorectum | MSS | 2.71e-26 | -5.12e-01 | 0.3005 |
| 64282 | TENT4B | F007 | Human | Colorectum | FAP | 1.37e-02 | -2.79e-01 | 0.1176 |
| 64282 | TENT4B | A001-C-207 | Human | Colorectum | FAP | 4.02e-02 | -2.27e-01 | 0.1278 |
| 64282 | TENT4B | A015-C-203 | Human | Colorectum | FAP | 8.58e-14 | -2.62e-01 | -0.1294 |
| 64282 | TENT4B | A015-C-204 | Human | Colorectum | FAP | 2.40e-02 | -5.07e-02 | -0.0228 |
| 64282 | TENT4B | A002-C-201 | Human | Colorectum | FAP | 1.16e-08 | -1.77e-01 | 0.0324 |
| 64282 | TENT4B | A001-C-119 | Human | Colorectum | FAP | 4.30e-06 | -3.26e-01 | -0.1557 |
| 64282 | TENT4B | A001-C-108 | Human | Colorectum | FAP | 3.19e-08 | -2.65e-01 | -0.0272 |
| 64282 | TENT4B | A002-C-205 | Human | Colorectum | FAP | 2.51e-13 | -1.90e-01 | -0.1236 |
| 64282 | TENT4B | A001-C-104 | Human | Colorectum | FAP | 7.81e-03 | -2.05e-01 | 0.0184 |
| 64282 | TENT4B | A015-C-005 | Human | Colorectum | FAP | 8.27e-04 | -1.94e-01 | -0.0336 |
| 64282 | TENT4B | A015-C-006 | Human | Colorectum | FAP | 7.80e-14 | -4.44e-01 | -0.0994 |
| 64282 | TENT4B | A015-C-106 | Human | Colorectum | FAP | 3.19e-09 | -2.94e-01 | -0.0511 |
| 64282 | TENT4B | A002-C-114 | Human | Colorectum | FAP | 6.24e-14 | -3.82e-01 | -0.1561 |
| 64282 | TENT4B | A015-C-104 | Human | Colorectum | FAP | 2.20e-16 | -3.01e-01 | -0.1899 |
| Page: 1 2 3 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Colorectum (GSE201348) |  | FAP: Familial adenomatous polyposis |
| CRC: Colorectal cancer | ||
| Colorectum (HTA11) |  | AD: Adenomas |
| SER: Sessile serrated lesions | ||
| MSI-H: Microsatellite-high colorectal cancer | ||
| MSS: Microsatellite stable colorectal cancer | ||
| Thyroid |  | ATC: Anaplastic thyroid cancer |
| HT: Hashimoto's thyroiditis | ||
| PTC: Papillary thyroid cancer |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:0009896 | Colorectum | AD | positive regulation of catabolic process | 180/3918 | 492/18723 | 4.33e-16 | 1.94e-13 | 180 |
| GO:1903311 | Colorectum | AD | regulation of mRNA metabolic process | 117/3918 | 288/18723 | 1.69e-14 | 4.23e-12 | 117 |
| GO:0031331 | Colorectum | AD | positive regulation of cellular catabolic process | 156/3918 | 427/18723 | 4.68e-14 | 1.05e-11 | 156 |
| GO:0009895 | Colorectum | AD | negative regulation of catabolic process | 124/3918 | 320/18723 | 1.66e-13 | 3.35e-11 | 124 |
| GO:0031330 | Colorectum | AD | negative regulation of cellular catabolic process | 104/3918 | 262/18723 | 2.66e-12 | 3.96e-10 | 104 |
| GO:0006401 | Colorectum | AD | RNA catabolic process | 102/3918 | 278/18723 | 8.64e-10 | 6.76e-08 | 102 |
| GO:0022613 | Colorectum | AD | ribonucleoprotein complex biogenesis | 151/3918 | 463/18723 | 1.96e-09 | 1.39e-07 | 151 |
| GO:0044270 | Colorectum | AD | cellular nitrogen compound catabolic process | 147/3918 | 451/18723 | 3.35e-09 | 2.23e-07 | 147 |
| GO:0046700 | Colorectum | AD | heterocycle catabolic process | 145/3918 | 445/18723 | 4.37e-09 | 2.84e-07 | 145 |
| GO:0006402 | Colorectum | AD | mRNA catabolic process | 87/3918 | 232/18723 | 4.40e-09 | 2.84e-07 | 87 |
| GO:0034655 | Colorectum | AD | nucleobase-containing compound catabolic process | 133/3918 | 407/18723 | 1.56e-08 | 9.12e-07 | 133 |
| GO:0019439 | Colorectum | AD | aromatic compound catabolic process | 146/3918 | 467/18723 | 7.48e-08 | 3.84e-06 | 146 |
| GO:1901361 | Colorectum | AD | organic cyclic compound catabolic process | 153/3918 | 495/18723 | 8.23e-08 | 4.18e-06 | 153 |
| GO:0010639 | Colorectum | AD | negative regulation of organelle organization | 114/3918 | 348/18723 | 1.41e-07 | 6.49e-06 | 114 |
| GO:0061013 | Colorectum | AD | regulation of mRNA catabolic process | 64/3918 | 166/18723 | 1.44e-07 | 6.59e-06 | 64 |
| GO:0051052 | Colorectum | AD | regulation of DNA metabolic process | 116/3918 | 359/18723 | 2.47e-07 | 1.00e-05 | 116 |
| GO:0043487 | Colorectum | AD | regulation of RNA stability | 63/3918 | 170/18723 | 9.17e-07 | 3.12e-05 | 63 |
| GO:0006417 | Colorectum | AD | regulation of translation | 141/3918 | 468/18723 | 1.32e-06 | 4.22e-05 | 141 |
| GO:0043488 | Colorectum | AD | regulation of mRNA stability | 59/3918 | 158/18723 | 1.50e-06 | 4.66e-05 | 59 |
| GO:0033500 | Colorectum | AD | carbohydrate homeostasis | 84/3918 | 259/18723 | 9.10e-06 | 2.15e-04 | 84 |
| Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| Page: 1 |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
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