GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00181055 | Liver | NAFLD | peptidyl-serine phosphorylation | 63/1882 | 315/18723 | 7.45e-08 | 6.60e-06 | 63 |
GO:00182094 | Liver | NAFLD | peptidyl-serine modification | 64/1882 | 338/18723 | 4.65e-07 | 2.89e-05 | 64 |
GO:00070157 | Liver | NAFLD | actin filament organization | 78/1882 | 442/18723 | 5.44e-07 | 3.21e-05 | 78 |
GO:19029037 | Liver | NAFLD | regulation of supramolecular fiber organization | 66/1882 | 383/18723 | 8.97e-06 | 2.96e-04 | 66 |
GO:00512227 | Liver | NAFLD | positive regulation of protein transport | 55/1882 | 303/18723 | 1.07e-05 | 3.35e-04 | 55 |
GO:00458606 | Liver | NAFLD | positive regulation of protein kinase activity | 65/1882 | 386/18723 | 2.22e-05 | 6.13e-04 | 65 |
GO:00329707 | Liver | NAFLD | regulation of actin filament-based process | 66/1882 | 397/18723 | 2.92e-05 | 7.72e-04 | 66 |
GO:19049517 | Liver | NAFLD | positive regulation of establishment of protein localization | 55/1882 | 319/18723 | 4.79e-05 | 1.14e-03 | 55 |
GO:19029057 | Liver | NAFLD | positive regulation of supramolecular fiber organization | 40/1882 | 209/18723 | 4.88e-05 | 1.15e-03 | 40 |
GO:00336747 | Liver | NAFLD | positive regulation of kinase activity | 74/1882 | 467/18723 | 5.16e-05 | 1.19e-03 | 74 |
GO:00329567 | Liver | NAFLD | regulation of actin cytoskeleton organization | 60/1882 | 358/18723 | 5.20e-05 | 1.20e-03 | 60 |
GO:01100537 | Liver | NAFLD | regulation of actin filament organization | 49/1882 | 278/18723 | 6.88e-05 | 1.46e-03 | 49 |
GO:00313465 | Liver | NAFLD | positive regulation of cell projection organization | 57/1882 | 353/18723 | 2.19e-04 | 3.73e-03 | 57 |
GO:00432547 | Liver | NAFLD | regulation of protein-containing complex assembly | 66/1882 | 428/18723 | 2.83e-04 | 4.53e-03 | 66 |
GO:00512587 | Liver | NAFLD | protein polymerization | 49/1882 | 297/18723 | 3.54e-04 | 5.36e-03 | 49 |
GO:00903166 | Liver | NAFLD | positive regulation of intracellular protein transport | 29/1882 | 160/18723 | 1.24e-03 | 1.41e-02 | 29 |
GO:00322717 | Liver | NAFLD | regulation of protein polymerization | 38/1882 | 233/18723 | 1.90e-03 | 1.93e-02 | 38 |
GO:00081547 | Liver | NAFLD | actin polymerization or depolymerization | 36/1882 | 218/18723 | 1.98e-03 | 1.98e-02 | 36 |
GO:00514957 | Liver | NAFLD | positive regulation of cytoskeleton organization | 37/1882 | 226/18723 | 2.02e-03 | 2.00e-02 | 37 |
GO:0033135 | Liver | NAFLD | regulation of peptidyl-serine phosphorylation | 26/1882 | 144/18723 | 2.28e-03 | 2.19e-02 | 26 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TENM1 | SNV | Missense_Mutation | novel | c.2285N>A | p.Arg762Gln | p.R762Q | Q9UKZ4 | protein_coding | tolerated(0.2) | benign(0) | TCGA-3C-AALI-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unspecific | Poly E | Complete Response |
TENM1 | SNV | Missense_Mutation | novel | c.3210N>T | p.Trp1070Cys | p.W1070C | Q9UKZ4 | protein_coding | deleterious(0.03) | benign(0.237) | TCGA-A2-A0CS-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Hormone Therapy | anastrozole | SD |
TENM1 | SNV | Missense_Mutation | | c.3745G>T | p.Ala1249Ser | p.A1249S | Q9UKZ4 | protein_coding | deleterious(0.05) | benign(0.14) | TCGA-A2-A0T3-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD |
TENM1 | SNV | Missense_Mutation | novel | c.5852C>A | p.Thr1951Asn | p.T1951N | Q9UKZ4 | protein_coding | deleterious(0.02) | benign(0.034) | TCGA-A7-A3IY-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | anastrozole | SD |
TENM1 | SNV | Missense_Mutation | rs758151979 | c.2608N>A | p.Asp870Asn | p.D870N | Q9UKZ4 | protein_coding | tolerated(0.22) | benign(0.007) | TCGA-A8-A07P-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | 5-fluorouracil | SD |
TENM1 | SNV | Missense_Mutation | | c.1548N>C | p.Met516Ile | p.M516I | Q9UKZ4 | protein_coding | tolerated(0.17) | benign(0.001) | TCGA-A8-A08L-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
TENM1 | SNV | Missense_Mutation | | c.6070N>G | p.Gln2024Glu | p.Q2024E | Q9UKZ4 | protein_coding | deleterious(0.02) | benign(0.057) | TCGA-A8-A08R-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TENM1 | SNV | Missense_Mutation | | c.3254A>C | p.Lys1085Thr | p.K1085T | Q9UKZ4 | protein_coding | deleterious(0) | possibly_damaging(0.787) | TCGA-A8-A093-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD |
TENM1 | SNV | Missense_Mutation | | c.7543N>A | p.Glu2515Lys | p.E2515K | Q9UKZ4 | protein_coding | tolerated(0.52) | benign(0.038) | TCGA-A8-A09Z-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TENM1 | SNV | Missense_Mutation | novel | c.4348N>A | p.Glu1450Lys | p.E1450K | Q9UKZ4 | protein_coding | deleterious(0) | probably_damaging(0.985) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |