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Gene: TDRD9 |
Gene summary for TDRD9 |
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Gene information | Species | Human | Gene symbol | TDRD9 | Gene ID | 122402 |
Gene name | tudor domain containing 9 | |
Gene Alias | C14orf75 | |
Cytomap | 14q32.33 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | Q86WA0 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
122402 | TDRD9 | Adj_PTCwithHT_6 | Human | Thyroid | HT | 2.56e-04 | -2.41e-01 | 0.02 |
122402 | TDRD9 | PTCwithHT_6 | Human | Thyroid | HT | 2.43e-03 | -2.34e-01 | 0.02 |
122402 | TDRD9 | PTCwithHT_8 | Human | Thyroid | HT | 5.67e-05 | -2.41e-01 | 0.0351 |
122402 | TDRD9 | PTCwithoutHT_2 | Human | Thyroid | PTC | 2.56e-04 | -2.41e-01 | 0.0419 |
122402 | TDRD9 | male-WTA | Human | Thyroid | PTC | 4.84e-04 | -2.04e-01 | 0.1037 |
122402 | TDRD9 | PTC01 | Human | Thyroid | PTC | 1.14e-02 | -2.32e-01 | 0.1899 |
122402 | TDRD9 | PTC03 | Human | Thyroid | PTC | 1.88e-02 | -5.48e-02 | 0.1784 |
122402 | TDRD9 | PTC06 | Human | Thyroid | PTC | 1.59e-03 | -1.63e-01 | 0.2057 |
122402 | TDRD9 | PTC07 | Human | Thyroid | PTC | 1.10e-11 | 6.74e-03 | 0.2044 |
122402 | TDRD9 | ATC12 | Human | Thyroid | ATC | 2.18e-11 | -1.20e-01 | 0.34 |
122402 | TDRD9 | ATC13 | Human | Thyroid | ATC | 1.35e-02 | -2.36e-01 | 0.34 |
122402 | TDRD9 | ATC4 | Human | Thyroid | ATC | 1.08e-10 | -9.63e-02 | 0.34 |
122402 | TDRD9 | ATC5 | Human | Thyroid | ATC | 1.04e-02 | -2.35e-01 | 0.34 |
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Tissue | Expression Dynamics | Abbreviation |
Thyroid | ![]() | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis | ||
PTC: Papillary thyroid cancer |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00346608 | Thyroid | PTC | ncRNA metabolic process | 239/5968 | 485/18723 | 5.54e-16 | 4.26e-14 | 239 |
GO:00322594 | Thyroid | PTC | methylation | 146/5968 | 364/18723 | 4.99e-04 | 3.26e-03 | 146 |
GO:00482855 | Thyroid | PTC | organelle fission | 188/5968 | 488/18723 | 9.64e-04 | 5.77e-03 | 188 |
GO:00434145 | Thyroid | PTC | macromolecule methylation | 127/5968 | 316/18723 | 1.02e-03 | 6.07e-03 | 127 |
GO:00002804 | Thyroid | PTC | nuclear division | 167/5968 | 439/18723 | 3.27e-03 | 1.60e-02 | 167 |
GO:003466021 | Thyroid | ATC | ncRNA metabolic process | 240/6293 | 485/18723 | 2.03e-13 | 9.91e-12 | 240 |
GO:004828512 | Thyroid | ATC | organelle fission | 229/6293 | 488/18723 | 4.79e-10 | 1.29e-08 | 229 |
GO:000028011 | Thyroid | ATC | nuclear division | 207/6293 | 439/18723 | 1.98e-09 | 4.80e-08 | 207 |
GO:004341412 | Thyroid | ATC | macromolecule methylation | 131/6293 | 316/18723 | 2.01e-03 | 9.60e-03 | 131 |
GO:003225911 | Thyroid | ATC | methylation | 148/6293 | 364/18723 | 2.69e-03 | 1.23e-02 | 148 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TDRD9 | SNV | Missense_Mutation | rs376816009 | c.772N>A | p.Glu258Lys | p.E258K | Q8NDG6 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TDRD9 | SNV | Missense_Mutation | novel | c.1099N>T | p.Asp367Tyr | p.D367Y | Q8NDG6 | protein_coding | deleterious(0) | possibly_damaging(0.707) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TDRD9 | SNV | Missense_Mutation | c.2384T>C | p.Leu795Pro | p.L795P | Q8NDG6 | protein_coding | deleterious(0) | probably_damaging(0.929) | TCGA-AR-A1AR-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unspecific | Docetaxel | PD | |
TDRD9 | SNV | Missense_Mutation | c.2824N>T | p.Pro942Ser | p.P942S | Q8NDG6 | protein_coding | tolerated(0.57) | benign(0.013) | TCGA-AR-A1AT-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | anastrozole | SD | |
TDRD9 | SNV | Missense_Mutation | rs867694067 | c.3805N>A | p.Asp1269Asn | p.D1269N | Q8NDG6 | protein_coding | deleterious(0.01) | probably_damaging(0.936) | TCGA-E2-A1IN-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | arimidex | SD |
TDRD9 | SNV | Missense_Mutation | novel | c.1556C>G | p.Pro519Arg | p.P519R | Q8NDG6 | protein_coding | deleterious(0.03) | benign(0.067) | TCGA-E9-A3X8-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cyclophosphane | CR |
TDRD9 | insertion | In_Frame_Ins | novel | c.2040_2041insTTTAGTTATGTTATTATTTCTAAT | p.Leu680_Arg681insPheSerTyrValIleIleSerAsn | p.L680_R681insFSYVIISN | Q8NDG6 | protein_coding | TCGA-A8-A0A1-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | SD | ||
TDRD9 | SNV | Missense_Mutation | c.2642C>A | p.Pro881His | p.P881H | Q8NDG6 | protein_coding | deleterious(0) | possibly_damaging(0.619) | TCGA-A6-3809-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
TDRD9 | SNV | Missense_Mutation | c.497C>T | p.Pro166Leu | p.P166L | Q8NDG6 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AA-3492-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
TDRD9 | SNV | Missense_Mutation | c.1067N>A | p.Ala356Asp | p.A356D | Q8NDG6 | protein_coding | deleterious(0) | probably_damaging(0.943) | TCGA-AA-3842-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | folinic | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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