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Gene: TDRD3 |
Gene summary for TDRD3 |
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Gene information | Species | Human | Gene symbol | TDRD3 | Gene ID | 81550 |
Gene name | tudor domain containing 3 | |
Gene Alias | TDRD3 | |
Cytomap | 13q21.2 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q9H7E2 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
81550 | TDRD3 | HTA11_3410_2000001011 | Human | Colorectum | AD | 2.52e-12 | -4.79e-01 | 0.0155 |
81550 | TDRD3 | HTA11_2487_2000001011 | Human | Colorectum | SER | 2.33e-02 | -3.13e-01 | -0.1808 |
81550 | TDRD3 | HTA11_3361_2000001011 | Human | Colorectum | AD | 1.69e-04 | -4.03e-01 | -0.1207 |
81550 | TDRD3 | HTA11_866_3004761011 | Human | Colorectum | AD | 1.39e-09 | -4.60e-01 | 0.096 |
81550 | TDRD3 | HTA11_7696_3000711011 | Human | Colorectum | AD | 4.37e-08 | -4.05e-01 | 0.0674 |
81550 | TDRD3 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 1.26e-06 | -3.70e-01 | 0.294 |
81550 | TDRD3 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 1.25e-10 | -4.64e-01 | 0.3005 |
81550 | TDRD3 | A002-C-010 | Human | Colorectum | FAP | 1.26e-02 | -1.15e-01 | 0.242 |
81550 | TDRD3 | A001-C-207 | Human | Colorectum | FAP | 4.98e-04 | -2.38e-01 | 0.1278 |
81550 | TDRD3 | A015-C-203 | Human | Colorectum | FAP | 3.90e-31 | -5.38e-01 | -0.1294 |
81550 | TDRD3 | A015-C-204 | Human | Colorectum | FAP | 4.10e-08 | -3.04e-01 | -0.0228 |
81550 | TDRD3 | A014-C-040 | Human | Colorectum | FAP | 7.02e-06 | -5.15e-01 | -0.1184 |
81550 | TDRD3 | A002-C-201 | Human | Colorectum | FAP | 8.94e-12 | -3.39e-01 | 0.0324 |
81550 | TDRD3 | A002-C-203 | Human | Colorectum | FAP | 3.14e-04 | -2.17e-01 | 0.2786 |
81550 | TDRD3 | A001-C-119 | Human | Colorectum | FAP | 3.90e-07 | -4.72e-01 | -0.1557 |
81550 | TDRD3 | A001-C-108 | Human | Colorectum | FAP | 2.27e-15 | -2.66e-01 | -0.0272 |
81550 | TDRD3 | A002-C-205 | Human | Colorectum | FAP | 1.65e-21 | -3.43e-01 | -0.1236 |
81550 | TDRD3 | A001-C-104 | Human | Colorectum | FAP | 4.33e-06 | -3.12e-01 | 0.0184 |
81550 | TDRD3 | A015-C-005 | Human | Colorectum | FAP | 6.47e-06 | -3.33e-01 | -0.0336 |
81550 | TDRD3 | A015-C-006 | Human | Colorectum | FAP | 1.01e-17 | -5.09e-01 | -0.0994 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0006325 | Colorectum | AD | chromatin organization | 119/3918 | 409/18723 | 4.85e-05 | 8.33e-04 | 119 |
GO:00063251 | Colorectum | SER | chromatin organization | 89/2897 | 409/18723 | 4.15e-04 | 6.17e-03 | 89 |
GO:00063252 | Colorectum | MSS | chromatin organization | 107/3467 | 409/18723 | 7.22e-05 | 1.21e-03 | 107 |
GO:00063253 | Colorectum | FAP | chromatin organization | 84/2622 | 409/18723 | 1.62e-04 | 2.47e-03 | 84 |
GO:00063254 | Colorectum | CRC | chromatin organization | 74/2078 | 409/18723 | 1.48e-05 | 4.61e-04 | 74 |
GO:00063255 | Liver | NAFLD | chromatin organization | 64/1882 | 409/18723 | 2.31e-04 | 3.89e-03 | 64 |
GO:000632511 | Liver | HCC | chromatin organization | 206/7958 | 409/18723 | 7.23e-04 | 4.41e-03 | 206 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TDRD3 | SNV | Missense_Mutation | c.121N>G | p.Leu41Val | p.L41V | Q9H7E2 | protein_coding | deleterious(0) | possibly_damaging(0.83) | TCGA-A8-A09V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | |
TDRD3 | SNV | Missense_Mutation | c.1853T>A | p.Ile618Lys | p.I618K | Q9H7E2 | protein_coding | tolerated(0.83) | benign(0.054) | TCGA-A8-A09Z-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
TDRD3 | deletion | Frame_Shift_Del | c.887delN | p.Thr296ArgfsTer21 | p.T296Rfs*21 | Q9H7E2 | protein_coding | TCGA-BH-A0DH-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cyclophosphamide | SD | |||
TDRD3 | SNV | Missense_Mutation | novel | c.644A>G | p.Lys215Arg | p.K215R | Q9H7E2 | protein_coding | deleterious(0.04) | probably_damaging(0.99) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
TDRD3 | SNV | Missense_Mutation | novel | c.1768G>A | p.Glu590Lys | p.E590K | Q9H7E2 | protein_coding | tolerated(0.22) | benign(0.228) | TCGA-C5-A2LZ-01 | Cervix | cervical & endocervical cancer | Female | >=65 | III/IV | Unknown | Unknown | PD |
TDRD3 | SNV | Missense_Mutation | novel | c.2125N>A | p.Glu709Lys | p.E709K | Q9H7E2 | protein_coding | deleterious(0.03) | possibly_damaging(0.829) | TCGA-C5-A8XJ-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Chemotherapy | cisplatin | SD |
TDRD3 | SNV | Missense_Mutation | c.475N>A | p.Glu159Lys | p.E159K | Q9H7E2 | protein_coding | deleterious(0) | benign(0.158) | TCGA-EK-A3GK-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
TDRD3 | SNV | Missense_Mutation | novel | c.248N>T | p.Lys83Met | p.K83M | Q9H7E2 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-Q1-A5R2-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | PR |
TDRD3 | SNV | Missense_Mutation | c.1508N>C | p.Met503Thr | p.M503T | Q9H7E2 | protein_coding | tolerated(0.19) | benign(0.027) | TCGA-A6-5661-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
TDRD3 | SNV | Missense_Mutation | novel | c.1007C>T | p.Pro336Leu | p.P336L | Q9H7E2 | protein_coding | deleterious(0.01) | probably_damaging(0.962) | TCGA-AA-3968-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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