Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: TDGF1

Gene summary for TDGF1

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

TDGF1

Gene ID

6997

Gene nameteratocarcinoma-derived growth factor 1
Gene AliasCR
Cytomap3p21.31
Gene Typeprotein-coding
GO ID

GO:0000165

UniProtAcc

F5H1T8


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
6997TDGF1Pt13.aHumanLiverHCC1.93e-021.32e-010.021
6997TDGF1S014HumanLiverHCC3.54e-251.01e+000.2254
6997TDGF1S015HumanLiverHCC4.15e-381.49e+000.2375
6997TDGF1S016HumanLiverHCC1.14e-371.32e+000.2243
6997TDGF1S029HumanLiverHCC5.90e-031.26e-010.2581
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
LiverThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.HCC: Hepatocellular carcinoma
NAFLD: Non-alcoholic fatty liver disease
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:004873222LiverHCCgland development242/7958436/187232.26e-085.28e-07242
GO:007084911LiverHCCresponse to epidermal growth factor37/795849/187232.70e-063.61e-0537
GO:007136411LiverHCCcellular response to epidermal growth factor stimulus34/795845/187236.75e-068.08e-0534
GO:001810511LiverHCCpeptidyl-serine phosphorylation169/7958315/187233.86e-053.81e-04169
GO:007190021LiverHCCregulation of protein serine/threonine kinase activity189/7958359/187235.97e-055.47e-04189
GO:00343411LiverHCCresponse to interferon-gamma82/7958141/187231.25e-041.03e-0382
GO:001820911LiverHCCpeptidyl-serine modification177/7958338/187231.45e-041.17e-03177
GO:00713461LiverHCCcellular response to interferon-gamma70/7958118/187231.66e-041.32e-0370
GO:0035729LiverHCCcellular response to hepatocyte growth factor stimulus14/795817/187239.39e-045.47e-0314
GO:003461211LiverHCCresponse to tumor necrosis factor132/7958253/187231.14e-036.48e-03132
GO:004586021LiverHCCpositive regulation of protein kinase activity194/7958386/187231.16e-036.54e-03194
GO:0035728LiverHCCresponse to hepatocyte growth factor15/795819/187231.36e-037.28e-0315
GO:003367411LiverHCCpositive regulation of kinase activity230/7958467/187231.72e-038.95e-03230
GO:00308795LiverHCCmammary gland development75/7958137/187232.52e-031.22e-0275
GO:007135611LiverHCCcellular response to tumor necrosis factor115/7958229/187231.08e-023.99e-02115
GO:000166721LiverHCCameboidal-type cell migration226/7958475/187231.35e-024.81e-02226
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
TDGF1SNVMissense_Mutationc.77N>Ap.Gly26Glup.G26EP13385protein_codingtolerated(0.3)benign(0.011)TCGA-E2-A10C-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapycytoxanSD
TDGF1insertionFrame_Shift_Insnovelc.364_365insTGTCTGACTTp.Thr122MetfsTer14p.T122Mfs*14P13385protein_codingTCGA-AN-A0FX-01Breastbreast invasive carcinomaFemale<65I/IIUnknownUnknownSD
TDGF1insertionNonsense_Mutationnovelc.366_367insTCTTCCTAGTGTGATTTGGATCAp.Trp123SerfsTer3p.W123Sfs*3P13385protein_codingTCGA-AN-A0FX-01Breastbreast invasive carcinomaFemale<65I/IIUnknownUnknownSD
TDGF1deletionFrame_Shift_Delc.263delNp.Cys89AlafsTer65p.C89Afs*65P13385protein_codingTCGA-D8-A27V-01Breastbreast invasive carcinomaFemale<65I/IIHormone TherapytamoxiphenSD
TDGF1deletionFrame_Shift_Delnovelc.273delNp.Ser93ProfsTer61p.S93Pfs*61P13385protein_codingTCGA-EW-A2FV-01Breastbreast invasive carcinomaFemale<65III/IVChemotherapydocetaxelSD
TDGF1SNVMissense_Mutationrs765803584c.260N>Ap.Gly87Glup.G87EP13385protein_codingdeleterious(0)probably_damaging(0.975)TCGA-BI-A0VR-01Cervixcervical & endocervical cancerFemale<65III/IVUnknownUnknownSD
TDGF1SNVMissense_Mutationc.442N>Cp.Gly148Argp.G148RP13385protein_codingdeleterious(0)probably_damaging(0.997)TCGA-ZJ-AAXB-01Cervixcervical & endocervical cancerFemale<65I/IIUnknownUnknownSD
TDGF1SNVMissense_Mutationnovelc.359N>Tp.His120Leup.H120LP13385protein_codingdeleterious(0)probably_damaging(0.999)TCGA-A6-3807-01Colorectumcolon adenocarcinomaFemale<65III/IVAncillaryleucovorinSD
TDGF1SNVMissense_Mutationrs774857986c.415C>Tp.Arg139Cysp.R139CP13385protein_codingdeleterious(0.01)possibly_damaging(0.825)TCGA-AA-3952-01Colorectumcolon adenocarcinomaMale>=65III/IVUnknownUnknownPD
TDGF1SNVMissense_Mutationc.292N>Ap.Pro98Thrp.P98TP13385protein_codingdeleterious(0.02)possibly_damaging(0.647)TCGA-AZ-4615-01Colorectumcolon adenocarcinomaMale>=65III/IVChemotherapyxelodaPD
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
6997TDGF1DRUGGABLE GENOME, CELL SURFACE, GROWTH FACTORBIIB 015
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