Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: TCTN1

Gene summary for TCTN1

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

TCTN1

Gene ID

79600

Gene nametectonic family member 1
Gene AliasJBTS13
Cytomap12q24.11
Gene Typeprotein-coding
GO ID

GO:0000902

UniProtAcc

B4DIB9


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
79600TCTN1LZE7THumanEsophagusESCC3.97e-054.97e-010.0667
79600TCTN1LZE8THumanEsophagusESCC2.97e-032.36e-010.067
79600TCTN1LZE24THumanEsophagusESCC1.61e-072.98e-010.0596
79600TCTN1P1T-EHumanEsophagusESCC1.83e-053.98e-010.0875
79600TCTN1P2T-EHumanEsophagusESCC8.91e-871.50e+000.1177
79600TCTN1P4T-EHumanEsophagusESCC5.84e-133.06e-010.1323
79600TCTN1P5T-EHumanEsophagusESCC7.96e-073.28e-020.1327
79600TCTN1P8T-EHumanEsophagusESCC1.52e-284.71e-010.0889
79600TCTN1P9T-EHumanEsophagusESCC1.12e-131.34e-010.1131
79600TCTN1P10T-EHumanEsophagusESCC2.88e-173.13e-010.116
79600TCTN1P11T-EHumanEsophagusESCC1.97e-261.13e+000.1426
79600TCTN1P12T-EHumanEsophagusESCC1.34e-212.28e-010.1122
79600TCTN1P15T-EHumanEsophagusESCC5.04e-131.50e-010.1149
79600TCTN1P16T-EHumanEsophagusESCC7.30e-661.10e+000.1153
79600TCTN1P17T-EHumanEsophagusESCC3.79e-105.04e-010.1278
79600TCTN1P19T-EHumanEsophagusESCC3.38e-056.17e-010.1662
79600TCTN1P20T-EHumanEsophagusESCC2.59e-192.55e-010.1124
79600TCTN1P21T-EHumanEsophagusESCC9.37e-233.73e-010.1617
79600TCTN1P22T-EHumanEsophagusESCC1.03e-406.46e-010.1236
79600TCTN1P23T-EHumanEsophagusESCC1.40e-152.30e-010.108
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
EsophagusThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ESCC: Esophageal squamous cell carcinoma
HGIN: High-grade intraepithelial neoplasias
LGIN: Low-grade intraepithelial neoplasias
LiverThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.HCC: Hepatocellular carcinoma
NAFLD: Non-alcoholic fatty liver disease
Oral CavityThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.EOLP: Erosive Oral lichen planus
LP: leukoplakia
NEOLP: Non-erosive oral lichen planus
OSCC: Oral squamous cell carcinoma
ThyroidThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ATC: Anaplastic thyroid cancer
HT: Hashimoto's thyroiditis
PTC: Papillary thyroid cancer
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:000170119EsophagusESCCin utero embryonic development243/8552367/187231.00e-156.86e-14243
GO:000184115EsophagusESCCneural tube formation75/8552102/187239.68e-091.95e-0775
GO:00219159EsophagusESCCneural tube development101/8552152/187231.78e-072.79e-06101
GO:00163316EsophagusESCCmorphogenesis of embryonic epithelium98/8552147/187232.12e-073.27e-0698
GO:000183814EsophagusESCCembryonic epithelial tube formation83/8552121/187232.78e-074.08e-0683
GO:003514815EsophagusESCCtube formation96/8552148/187231.86e-062.16e-0596
GO:00721759EsophagusESCCepithelial tube formation86/8552132/187234.81e-065.10e-0586
GO:006056210EsophagusESCCepithelial tube morphogenesis187/8552325/187239.95e-069.44e-05187
GO:006156415EsophagusESCCaxon development251/8552467/187232.41e-041.49e-03251
GO:000740915EsophagusESCCaxonogenesis219/8552418/187233.14e-031.31e-02219
GO:00017015LiverCirrhoticin utero embryonic development134/4634367/187232.78e-076.86e-06134
GO:000170111LiverHCCin utero embryonic development204/7958367/187232.44e-074.30e-06204
GO:00018415LiverHCCneural tube formation62/7958102/187231.47e-041.18e-0362
GO:00219154LiverHCCneural tube development82/7958152/187232.83e-031.33e-0282
GO:00018384LiverHCCembryonic epithelial tube formation66/7958121/187234.94e-032.07e-0266
GO:00721754LiverHCCepithelial tube formation70/7958132/187239.29e-033.57e-0270
GO:00351484LiverHCCtube formation77/7958148/187231.20e-024.39e-0277
GO:000170116Oral cavityOSCCin utero embryonic development207/7305367/187237.92e-122.95e-10207
GO:000184110Oral cavityOSCCneural tube formation60/7305102/187233.90e-053.43e-0460
GO:00018388Oral cavityOSCCembryonic epithelial tube formation66/7305121/187233.70e-042.26e-0366
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
TCTN1SNVMissense_Mutationc.1391G>Cp.Gly464Alap.G464AQ2MV58protein_codingdeleterious(0)probably_damaging(1)TCGA-AN-A0FW-01Breastbreast invasive carcinomaFemale>=65III/IVUnknownUnknownSD
TCTN1SNVMissense_Mutationc.402N>Ap.Asn134Lysp.N134KQ2MV58protein_codingdeleterious(0.03)benign(0.117)TCGA-BH-A0BQ-01Breastbreast invasive carcinomaFemale<65I/IIUnknownUnknownPD
TCTN1SNVMissense_Mutationnovelc.1556N>Ap.Thr519Asnp.T519NQ2MV58protein_codingdeleterious(0)probably_damaging(0.999)TCGA-LL-A441-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapytaxotereCR
TCTN1SNVMissense_Mutationrs753674051c.1411N>Ap.Val471Metp.V471MQ2MV58protein_codingdeleterious(0)probably_damaging(0.982)TCGA-OL-A5D6-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownSD
TCTN1SNVMissense_Mutationnovelc.820A>Tp.Arg274Trpp.R274WQ2MV58protein_codingdeleterious(0.01)possibly_damaging(0.575)TCGA-XX-A899-01Breastbreast invasive carcinomaFemale<65III/IVChemotherapycytoxanCR
TCTN1insertionFrame_Shift_Insnovelc.686_687insCAGCCACCTAGTTCCTGp.Leu230SerfsTer18p.L230Sfs*18Q2MV58protein_codingTCGA-AN-A0FK-01Breastbreast invasive carcinomaFemale>=65III/IVUnknownUnknownSD
TCTN1SNVMissense_Mutationrs369266915c.1283N>Ap.Arg428Glnp.R428QQ2MV58protein_codingdeleterious(0)probably_damaging(0.999)TCGA-C5-A902-01Cervixcervical & endocervical cancerFemale<65I/IIChemotherapycisplatinSD
TCTN1SNVMissense_Mutationrs780494395c.424N>Tp.Leu142Phep.L142FQ2MV58protein_codingdeleterious(0.01)possibly_damaging(0.89)TCGA-VS-A8EC-01Cervixcervical & endocervical cancerFemale<65III/IVChemotherapycarboplatinCR
TCTN1SNVMissense_Mutationc.382T>Cp.Ser128Prop.S128PQ2MV58protein_codingdeleterious(0)probably_damaging(0.942)TCGA-A6-A566-01Colorectumcolon adenocarcinomaFemale<65III/IVChemotherapyoxaliplatinPD
TCTN1SNVMissense_Mutationnovelc.1489N>Tp.Arg497Trpp.R497WQ2MV58protein_codingdeleterious(0.02)possibly_damaging(0.598)TCGA-AA-3821-01Colorectumcolon adenocarcinomaFemale>=65I/IIUnknownUnknownSD
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
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