|
|||||
|
 | |
| |
| |
| |
| |
| |
|
Gene: TCP11L1 |
Gene summary for TCP11L1 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | TCP11L1 | Gene ID | 55346 |
| Gene name | t-complex 11 like 1 | |
| Gene Alias | dJ85M6.3 | |
| Cytomap | 11p13 | |
| Gene Type | protein-coding | GO ID | GO:0007154 | UniProtAcc | Q9NUJ3 |
Top |
Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 55346 | TCP11L1 | LZE4T | Human | Esophagus | ESCC | 4.09e-09 | 2.04e-01 | 0.0811 |
| 55346 | TCP11L1 | P2T-E | Human | Esophagus | ESCC | 2.38e-06 | 1.63e-01 | 0.1177 |
| 55346 | TCP11L1 | P4T-E | Human | Esophagus | ESCC | 4.02e-06 | 1.38e-01 | 0.1323 |
| 55346 | TCP11L1 | P5T-E | Human | Esophagus | ESCC | 1.47e-14 | 2.34e-01 | 0.1327 |
| 55346 | TCP11L1 | P9T-E | Human | Esophagus | ESCC | 1.94e-09 | 1.77e-01 | 0.1131 |
| 55346 | TCP11L1 | P10T-E | Human | Esophagus | ESCC | 2.05e-07 | 1.38e-01 | 0.116 |
| 55346 | TCP11L1 | P11T-E | Human | Esophagus | ESCC | 9.92e-15 | 3.70e-01 | 0.1426 |
| 55346 | TCP11L1 | P12T-E | Human | Esophagus | ESCC | 7.90e-03 | 6.71e-02 | 0.1122 |
| 55346 | TCP11L1 | P15T-E | Human | Esophagus | ESCC | 7.15e-07 | 1.90e-01 | 0.1149 |
| 55346 | TCP11L1 | P17T-E | Human | Esophagus | ESCC | 1.63e-03 | 2.51e-01 | 0.1278 |
| 55346 | TCP11L1 | P20T-E | Human | Esophagus | ESCC | 9.15e-06 | 1.96e-01 | 0.1124 |
| 55346 | TCP11L1 | P21T-E | Human | Esophagus | ESCC | 3.89e-12 | 2.58e-01 | 0.1617 |
| 55346 | TCP11L1 | P22T-E | Human | Esophagus | ESCC | 2.56e-16 | 2.65e-01 | 0.1236 |
| 55346 | TCP11L1 | P23T-E | Human | Esophagus | ESCC | 9.21e-07 | 1.74e-01 | 0.108 |
| 55346 | TCP11L1 | P24T-E | Human | Esophagus | ESCC | 1.96e-05 | 1.27e-01 | 0.1287 |
| 55346 | TCP11L1 | P26T-E | Human | Esophagus | ESCC | 2.02e-06 | 1.39e-01 | 0.1276 |
| 55346 | TCP11L1 | P27T-E | Human | Esophagus | ESCC | 9.20e-06 | 1.53e-01 | 0.1055 |
| 55346 | TCP11L1 | P28T-E | Human | Esophagus | ESCC | 1.66e-17 | 3.82e-01 | 0.1149 |
| 55346 | TCP11L1 | P30T-E | Human | Esophagus | ESCC | 1.24e-04 | 2.62e-01 | 0.137 |
| 55346 | TCP11L1 | P31T-E | Human | Esophagus | ESCC | 9.44e-07 | 1.38e-01 | 0.1251 |
| Page: 1 2 3 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| Page: 1 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
Top |
Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| TCP11L1 | SNV | Missense_Mutation | c.148N>A | p.Val50Met | p.V50M | Q9NUJ3 | protein_coding | tolerated(0.12) | benign(0.111) | TCGA-BH-A0HF-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD | |
| TCP11L1 | SNV | Missense_Mutation | c.558G>A | p.Met186Ile | p.M186I | Q9NUJ3 | protein_coding | tolerated(0.34) | benign(0.003) | TCGA-C5-A1MK-01 | Cervix | cervical & endocervical cancer | Female | >=65 | III/IV | Chemotherapy | carboplatin | PD | |
| TCP11L1 | SNV | Missense_Mutation | novel | c.736N>A | p.Glu246Lys | p.E246K | Q9NUJ3 | protein_coding | deleterious(0) | possibly_damaging(0.767) | TCGA-VS-A959-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Unknown | Unknown | SD |
| TCP11L1 | SNV | Missense_Mutation | c.551N>G | p.Ile184Ser | p.I184S | Q9NUJ3 | protein_coding | deleterious(0) | possibly_damaging(0.867) | TCGA-AA-3489-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
| TCP11L1 | SNV | Missense_Mutation | c.1267G>A | p.Val423Met | p.V423M | Q9NUJ3 | protein_coding | tolerated(0.26) | possibly_damaging(0.595) | TCGA-AD-6901-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Chemotherapy | xeloda | PD | |
| TCP11L1 | SNV | Missense_Mutation | c.488A>G | p.Asp163Gly | p.D163G | Q9NUJ3 | protein_coding | deleterious(0) | benign(0.243) | TCGA-DM-A0X9-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
| TCP11L1 | SNV | Missense_Mutation | rs776793977 | c.562N>A | p.Gly188Arg | p.G188R | Q9NUJ3 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-F4-6570-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| TCP11L1 | SNV | Missense_Mutation | rs754291466 | c.121A>G | p.Lys41Glu | p.K41E | Q9NUJ3 | protein_coding | tolerated(0.24) | benign(0.026) | TCGA-DC-5337-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
| TCP11L1 | deletion | Frame_Shift_Del | c.32delA | p.Asn11MetfsTer30 | p.N11Mfs*30 | Q9NUJ3 | protein_coding | TCGA-CA-5797-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |||
| TCP11L1 | SNV | Missense_Mutation | rs774867726 | c.848N>T | p.Ala283Val | p.A283V | Q9NUJ3 | protein_coding | tolerated(0.11) | benign(0.13) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
| Page: 1 2 3 4 5 |
Top |
Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
Copyright 2023-Present -The University of Texas Health Science Center at Houston |