Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: TCHH

Gene summary for TCHH

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

TCHH

Gene ID

7062

Gene nametrichohyalin
Gene AliasTHH
Cytomap1q21.3
Gene Typeprotein-coding
GO ID

GO:0006996

UniProtAcc

Q07283


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
7062TCHHLZE4THumanEsophagusESCC1.48e-341.25e+000.0811
7062TCHHLZE22THumanEsophagusESCC1.54e-044.15e-010.068
7062TCHHP15T-EHumanEsophagusESCC5.62e-307.97e-010.1149
7062TCHHP17T-EHumanEsophagusESCC2.68e-032.84e-010.1278
7062TCHHP28T-EHumanEsophagusESCC5.03e-376.36e-010.1149
7062TCHHP36T-EHumanEsophagusESCC1.47e-146.33e-010.1187
7062TCHHP84T-EHumanEsophagusESCC1.34e-042.45e-010.0933
7062TCHHC06HumanOral cavityOSCC6.22e-045.36e-010.2699
7062TCHHC08HumanOral cavityOSCC2.11e-245.28e-010.1919
7062TCHHSYSMH5HumanOral cavityOSCC4.24e-062.61e-010.0647
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
EsophagusThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ESCC: Esophageal squamous cell carcinoma
HGIN: High-grade intraepithelial neoplasias
LGIN: Low-grade intraepithelial neoplasias
Oral CavityThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.EOLP: Erosive Oral lichen planus
LP: leukoplakia
NEOLP: Non-erosive oral lichen planus
OSCC: Oral squamous cell carcinoma
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:00435888EsophagusESCCskin development163/8552263/187236.48e-081.14e-06163
GO:000854410EsophagusESCCepidermis development193/8552324/187232.87e-074.19e-06193
GO:000991310EsophagusESCCepidermal cell differentiation122/8552202/187231.69e-051.51e-04122
GO:00302167EsophagusESCCkeratinocyte differentiation86/8552139/187238.53e-056.19e-0486
GO:00451035EsophagusESCCintermediate filament-based process32/855252/187231.55e-024.97e-0232
GO:00435887Oral cavityOSCCskin development143/7305263/187232.77e-074.27e-06143
GO:00085449Oral cavityOSCCepidermis development171/7305324/187232.89e-074.43e-06171
GO:00302166Oral cavityOSCCkeratinocyte differentiation81/7305139/187233.16e-063.81e-0581
GO:00099139Oral cavityOSCCepidermal cell differentiation109/7305202/187231.08e-051.14e-04109
GO:00451044Oral cavityOSCCintermediate filament cytoskeleton organization31/730551/187231.34e-036.62e-0331
GO:00451034Oral cavityOSCCintermediate filament-based process31/730552/187232.08e-039.59e-0331
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
TCHHSNVMissense_Mutationnovelc.479N>Ap.Arg160Glnp.R160QQ07283protein_codingtolerated_low_confidence(0.05)benign(0.261)TCGA-A1-A0SE-01Breastbreast invasive carcinomaFemale<65I/IIUnknownUnknownSD
TCHHSNVMissense_Mutationc.4285N>Ap.Asp1429Asnp.D1429NQ07283protein_codingdeleterious_low_confidence(0.01)benign(0.11)TCGA-A1-A0SI-01Breastbreast invasive carcinomaFemale<65I/IIUnknownUnknownSD
TCHHSNVMissense_Mutationnovelc.3321N>Cp.Glu1107Aspp.E1107DQ07283protein_codingdeleterious_low_confidence(0)benign(0.003)TCGA-A1-A0SN-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapyacSD
TCHHSNVMissense_Mutationrs751135364c.5143N>Ap.Gln1715Lysp.Q1715KQ07283protein_codingdeleterious_low_confidence(0.01)benign(0.071)TCGA-A2-A04Q-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapyadriamycinSD
TCHHSNVMissense_Mutationc.553N>Cp.Glu185Glnp.E185QQ07283protein_codingdeleterious_low_confidence(0.01)benign(0.035)TCGA-A2-A0CT-01Breastbreast invasive carcinomaFemale>=65I/IIChemotherapycytoxanSD
TCHHSNVMissense_Mutationc.3385N>Ap.Glu1129Lysp.E1129KQ07283protein_codingdeleterious_low_confidence(0.01)benign(0.019)TCGA-A2-A0D0-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapycytoxanSD
TCHHSNVMissense_Mutationc.202N>Tp.Arg68Cysp.R68CQ07283protein_codingtolerated_low_confidence(0.07)probably_damaging(0.961)TCGA-A2-A0SW-01Breastbreast invasive carcinomaFemale>=65III/IVHormone TherapyarimidexPD
TCHHSNVMissense_Mutationrs751135364c.5143N>Ap.Gln1715Lysp.Q1715KQ07283protein_codingdeleterious_low_confidence(0.01)benign(0.071)TCGA-A2-A0T2-01Breastbreast invasive carcinomaFemale>=65III/IVChemotherapyxelodaPD
TCHHSNVMissense_Mutationrs751135364c.5143C>Ap.Gln1715Lysp.Q1715KQ07283protein_codingdeleterious_low_confidence(0.01)benign(0.071)TCGA-A2-A0YE-01Breastbreast invasive carcinomaFemale<65I/IIUnspecificTaxotereSD
TCHHSNVMissense_Mutationc.3403G>Ap.Glu1135Lysp.E1135KQ07283protein_codingtolerated_low_confidence(0.14)benign(0.043)TCGA-A2-A25A-01Breastbreast invasive carcinomaFemale<65I/IIUnspecificCytoxanSD
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
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