|
Gene: TCF25 |
Gene summary for TCF25 |
Gene summary. |
Gene information | Species | Human | Gene symbol | TCF25 | Gene ID | 22980 |
Gene name | transcription factor 25 | |
Gene Alias | FKSG26 | |
Cytomap | 16q24.3 | |
Gene Type | protein-coding | GO ID | GO:0000122 | UniProtAcc | Q9BQ70 |
Top |
Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
22980 | TCF25 | HTA11_2487_2000001011 | Human | Colorectum | SER | 8.91e-03 | 3.82e-01 | -0.1808 |
22980 | TCF25 | HTA11_347_2000001011 | Human | Colorectum | AD | 4.84e-20 | 7.30e-01 | -0.1954 |
22980 | TCF25 | HTA11_411_2000001011 | Human | Colorectum | SER | 1.12e-02 | 7.10e-01 | -0.2602 |
22980 | TCF25 | HTA11_3361_2000001011 | Human | Colorectum | AD | 1.44e-04 | 4.84e-01 | -0.1207 |
22980 | TCF25 | HTA11_83_2000001011 | Human | Colorectum | SER | 4.04e-03 | 4.08e-01 | -0.1526 |
22980 | TCF25 | HTA11_696_2000001011 | Human | Colorectum | AD | 5.74e-16 | 6.86e-01 | -0.1464 |
22980 | TCF25 | HTA11_866_2000001011 | Human | Colorectum | AD | 3.89e-08 | 4.35e-01 | -0.1001 |
22980 | TCF25 | HTA11_1391_2000001011 | Human | Colorectum | AD | 3.33e-12 | 7.89e-01 | -0.059 |
22980 | TCF25 | HTA11_546_2000001011 | Human | Colorectum | AD | 1.06e-02 | 6.13e-01 | -0.0842 |
22980 | TCF25 | HTA11_8622_2000001021 | Human | Colorectum | SER | 9.18e-03 | 5.35e-01 | 0.0528 |
22980 | TCF25 | HTA11_10711_2000001011 | Human | Colorectum | AD | 9.44e-03 | 4.02e-01 | 0.0338 |
22980 | TCF25 | HTA11_7696_3000711011 | Human | Colorectum | AD | 1.43e-09 | 6.18e-01 | 0.0674 |
22980 | TCF25 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 2.01e-06 | 5.71e-01 | 0.3859 |
22980 | TCF25 | A001-C-207 | Human | Colorectum | FAP | 3.89e-02 | -3.91e-02 | 0.1278 |
22980 | TCF25 | A015-C-203 | Human | Colorectum | FAP | 1.07e-30 | 1.09e-02 | -0.1294 |
22980 | TCF25 | A015-C-204 | Human | Colorectum | FAP | 4.48e-05 | 5.35e-02 | -0.0228 |
22980 | TCF25 | A014-C-040 | Human | Colorectum | FAP | 1.01e-03 | 1.40e-01 | -0.1184 |
22980 | TCF25 | A002-C-201 | Human | Colorectum | FAP | 1.23e-11 | -8.08e-02 | 0.0324 |
22980 | TCF25 | A002-C-203 | Human | Colorectum | FAP | 1.74e-03 | 5.21e-02 | 0.2786 |
22980 | TCF25 | A001-C-119 | Human | Colorectum | FAP | 2.59e-12 | 3.08e-01 | -0.1557 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 |
Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
Page: 1 |
Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TCF25 | SNV | Missense_Mutation | c.143C>A | p.Pro48His | p.P48H | Q9BQ70 | protein_coding | deleterious(0.04) | benign(0.237) | TCGA-A2-A0YE-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unspecific | Taxotere | SD | |
TCF25 | SNV | Missense_Mutation | c.1309N>C | p.Glu437Gln | p.E437Q | Q9BQ70 | protein_coding | tolerated(0.25) | benign(0.027) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
TCF25 | SNV | Missense_Mutation | novel | c.1379N>A | p.Gly460Glu | p.G460E | Q9BQ70 | protein_coding | deleterious(0) | probably_damaging(0.96) | TCGA-OL-A66I-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | CR |
TCF25 | insertion | Frame_Shift_Ins | novel | c.343_344insGAGTCACTGCTGTGTCCAACAGTCTCGGGTTCTTGCATCTTTCCCGT | p.Pro115ArgfsTer49 | p.P115Rfs*49 | Q9BQ70 | protein_coding | TCGA-B6-A0I5-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
TCF25 | SNV | Missense_Mutation | rs748279421 | c.1877A>G | p.Glu626Gly | p.E626G | Q9BQ70 | protein_coding | deleterious(0.05) | benign(0.025) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
TCF25 | SNV | Missense_Mutation | rs773616241 | c.1594G>A | p.Ala532Thr | p.A532T | Q9BQ70 | protein_coding | tolerated(0.08) | benign(0.11) | TCGA-EA-A410-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
TCF25 | SNV | Missense_Mutation | rs772866312 | c.1978G>A | p.Asp660Asn | p.D660N | Q9BQ70 | protein_coding | tolerated(0.2) | benign(0.009) | TCGA-EA-A410-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
TCF25 | SNV | Missense_Mutation | c.160N>C | p.Glu54Gln | p.E54Q | Q9BQ70 | protein_coding | tolerated(0.27) | benign(0.001) | TCGA-JW-A5VL-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
TCF25 | SNV | Missense_Mutation | rs766179873 | c.428N>T | p.Ser143Leu | p.S143L | Q9BQ70 | protein_coding | tolerated(0.32) | benign(0) | TCGA-JX-A3Q0-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unknown | Unknown | SD |
TCF25 | SNV | Missense_Mutation | rs747448389 | c.826N>A | p.Val276Met | p.V276M | Q9BQ70 | protein_coding | deleterious(0.05) | possibly_damaging(0.79) | TCGA-A6-2685-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
Page: 1 2 3 4 5 6 |
Top |
Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |