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Gene: TCEB3 |
Gene summary for TCEB3 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | TCEB3 | Gene ID | 6924 |
| Gene name | elongin A | |
| Gene Alias | SIII | |
| Cytomap | 1p36.11 | |
| Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q14241 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 6924 | TCEB3 | P1T-E | Human | Esophagus | ESCC | 7.04e-09 | 2.23e-01 | 0.0875 |
| 6924 | TCEB3 | P2T-E | Human | Esophagus | ESCC | 4.50e-21 | 4.85e-01 | 0.1177 |
| 6924 | TCEB3 | P4T-E | Human | Esophagus | ESCC | 3.27e-15 | 4.06e-01 | 0.1323 |
| 6924 | TCEB3 | P5T-E | Human | Esophagus | ESCC | 1.83e-13 | 1.38e-01 | 0.1327 |
| 6924 | TCEB3 | P8T-E | Human | Esophagus | ESCC | 3.24e-14 | 1.74e-01 | 0.0889 |
| 6924 | TCEB3 | P9T-E | Human | Esophagus | ESCC | 9.47e-17 | 4.98e-02 | 0.1131 |
| 6924 | TCEB3 | P10T-E | Human | Esophagus | ESCC | 2.96e-18 | 3.99e-01 | 0.116 |
| 6924 | TCEB3 | P12T-E | Human | Esophagus | ESCC | 7.59e-16 | 1.86e-01 | 0.1122 |
| 6924 | TCEB3 | P15T-E | Human | Esophagus | ESCC | 1.96e-11 | 3.72e-01 | 0.1149 |
| 6924 | TCEB3 | P16T-E | Human | Esophagus | ESCC | 1.07e-21 | 2.71e-01 | 0.1153 |
| 6924 | TCEB3 | P17T-E | Human | Esophagus | ESCC | 1.17e-05 | 3.50e-01 | 0.1278 |
| 6924 | TCEB3 | P20T-E | Human | Esophagus | ESCC | 7.87e-15 | 2.74e-01 | 0.1124 |
| 6924 | TCEB3 | P21T-E | Human | Esophagus | ESCC | 8.49e-15 | 4.44e-01 | 0.1617 |
| 6924 | TCEB3 | P22T-E | Human | Esophagus | ESCC | 2.45e-11 | 7.10e-02 | 0.1236 |
| 6924 | TCEB3 | P23T-E | Human | Esophagus | ESCC | 2.80e-12 | 5.04e-01 | 0.108 |
| 6924 | TCEB3 | P24T-E | Human | Esophagus | ESCC | 3.84e-13 | 1.91e-01 | 0.1287 |
| 6924 | TCEB3 | P26T-E | Human | Esophagus | ESCC | 5.82e-14 | 2.49e-01 | 0.1276 |
| 6924 | TCEB3 | P27T-E | Human | Esophagus | ESCC | 1.21e-14 | 3.39e-01 | 0.1055 |
| 6924 | TCEB3 | P28T-E | Human | Esophagus | ESCC | 2.93e-19 | 4.60e-01 | 0.1149 |
| 6924 | TCEB3 | P30T-E | Human | Esophagus | ESCC | 3.26e-17 | 7.70e-01 | 0.137 |
| Page: 1 2 3 4 5 6 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias | ||
| Oral Cavity |  | EOLP: Erosive Oral lichen planus |
| LP: leukoplakia | ||
| NEOLP: Non-erosive oral lichen planus | ||
| OSCC: Oral squamous cell carcinoma | ||
| Prostate |  | BPH: Benign Prostatic Hyperplasia |
| Skin |  | AK: Actinic keratosis |
| cSCC: Cutaneous squamous cell carcinoma | ||
| SCCIS:squamous cell carcinoma in situ |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| Page: 1 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| Page: 1 |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
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