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Gene: TBC1D19 |
Gene summary for TBC1D19 |
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Gene information | Species | Human | Gene symbol | TBC1D19 | Gene ID | 55296 |
Gene name | TBC1 domain family member 19 | |
Gene Alias | TBC1D19 | |
Cytomap | 4p15.2 | |
Gene Type | protein-coding | GO ID | GO:0008150 | UniProtAcc | Q8N5T2 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
55296 | TBC1D19 | P2T-E | Human | Esophagus | ESCC | 2.93e-15 | 2.59e-01 | 0.1177 |
55296 | TBC1D19 | P5T-E | Human | Esophagus | ESCC | 5.33e-05 | 3.59e-02 | 0.1327 |
55296 | TBC1D19 | P8T-E | Human | Esophagus | ESCC | 9.56e-08 | 1.59e-01 | 0.0889 |
55296 | TBC1D19 | P9T-E | Human | Esophagus | ESCC | 3.05e-03 | 1.01e-01 | 0.1131 |
55296 | TBC1D19 | P10T-E | Human | Esophagus | ESCC | 4.40e-09 | 1.34e-01 | 0.116 |
55296 | TBC1D19 | P11T-E | Human | Esophagus | ESCC | 1.13e-06 | 2.17e-01 | 0.1426 |
55296 | TBC1D19 | P12T-E | Human | Esophagus | ESCC | 8.40e-04 | 1.03e-01 | 0.1122 |
55296 | TBC1D19 | P15T-E | Human | Esophagus | ESCC | 3.26e-02 | 6.68e-02 | 0.1149 |
55296 | TBC1D19 | P16T-E | Human | Esophagus | ESCC | 9.35e-10 | 1.65e-01 | 0.1153 |
55296 | TBC1D19 | P20T-E | Human | Esophagus | ESCC | 2.18e-03 | 8.76e-02 | 0.1124 |
55296 | TBC1D19 | P21T-E | Human | Esophagus | ESCC | 7.74e-41 | 7.86e-01 | 0.1617 |
55296 | TBC1D19 | P22T-E | Human | Esophagus | ESCC | 3.90e-16 | 1.28e-01 | 0.1236 |
55296 | TBC1D19 | P26T-E | Human | Esophagus | ESCC | 3.50e-02 | 6.24e-02 | 0.1276 |
55296 | TBC1D19 | P27T-E | Human | Esophagus | ESCC | 1.68e-08 | 7.85e-02 | 0.1055 |
55296 | TBC1D19 | P30T-E | Human | Esophagus | ESCC | 2.31e-10 | 2.86e-01 | 0.137 |
55296 | TBC1D19 | P32T-E | Human | Esophagus | ESCC | 3.75e-03 | 7.89e-02 | 0.1666 |
55296 | TBC1D19 | P37T-E | Human | Esophagus | ESCC | 3.53e-03 | 8.78e-02 | 0.1371 |
55296 | TBC1D19 | P42T-E | Human | Esophagus | ESCC | 9.05e-04 | 1.15e-01 | 0.1175 |
55296 | TBC1D19 | P47T-E | Human | Esophagus | ESCC | 1.41e-03 | 5.23e-02 | 0.1067 |
55296 | TBC1D19 | P48T-E | Human | Esophagus | ESCC | 3.97e-04 | 8.42e-02 | 0.0959 |
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Tissue | Expression Dynamics | Abbreviation |
Esophagus | ![]() | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias | ||
LGIN: Low-grade intraepithelial neoplasias |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TBC1D19 | SNV | Missense_Mutation | c.870N>T | p.Leu290Phe | p.L290F | Q8N5T2 | protein_coding | deleterious(0.01) | probably_damaging(0.996) | TCGA-AR-A0TP-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD | |
TBC1D19 | SNV | Missense_Mutation | c.679G>C | p.Glu227Gln | p.E227Q | Q8N5T2 | protein_coding | deleterious(0.02) | benign(0.02) | TCGA-D8-A27G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
TBC1D19 | SNV | Missense_Mutation | rs775883585 | c.282G>A | p.Met94Ile | p.M94I | Q8N5T2 | protein_coding | tolerated(0.36) | benign(0.028) | TCGA-EW-A1P3-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | fluorouracil | SD |
TBC1D19 | SNV | Missense_Mutation | rs377374054 | c.1016N>T | p.Ser339Leu | p.S339L | Q8N5T2 | protein_coding | deleterious(0.01) | benign(0.015) | TCGA-C5-A7UH-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Chemotherapy | cisplatin | SD |
TBC1D19 | SNV | Missense_Mutation | c.497N>T | p.Arg166Leu | p.R166L | Q8N5T2 | protein_coding | deleterious(0.01) | possibly_damaging(0.457) | TCGA-VS-A8EH-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Chemotherapy | cisplatin | CR | |
TBC1D19 | SNV | Missense_Mutation | c.1513N>A | p.Leu505Ile | p.L505I | Q8N5T2 | protein_coding | deleterious(0.01) | possibly_damaging(0.638) | TCGA-AA-3977-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
TBC1D19 | SNV | Missense_Mutation | rs760724863 | c.1324C>T | p.Arg442Cys | p.R442C | Q8N5T2 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-CA-6718-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | PD |
TBC1D19 | SNV | Missense_Mutation | c.1259N>G | p.Thr420Ser | p.T420S | Q8N5T2 | protein_coding | tolerated(0.37) | benign(0.007) | TCGA-CK-4951-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
TBC1D19 | SNV | Missense_Mutation | c.997T>A | p.Phe333Ile | p.F333I | Q8N5T2 | protein_coding | tolerated(0.18) | probably_damaging(0.994) | TCGA-CM-5341-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | fluorouracil | SD | |
TBC1D19 | SNV | Missense_Mutation | c.999T>G | p.Phe333Leu | p.F333L | Q8N5T2 | protein_coding | tolerated(0.27) | probably_damaging(0.991) | TCGA-CM-5341-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | fluorouracil | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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