![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: TBC1D13 |
Gene summary for TBC1D13 |
![]() |
Gene information | Species | Human | Gene symbol | TBC1D13 | Gene ID | 54662 |
Gene name | TBC1 domain family member 13 | |
Gene Alias | TBC1D13 | |
Cytomap | 9q34.11 | |
Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | A0A024R8B1 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
54662 | TBC1D13 | HCC1_Meng | Human | Liver | HCC | 5.95e-17 | -1.02e-02 | 0.0246 |
54662 | TBC1D13 | HCC2_Meng | Human | Liver | HCC | 2.20e-03 | 1.08e-02 | 0.0107 |
54662 | TBC1D13 | HCC1 | Human | Liver | HCC | 1.02e-04 | 3.66e+00 | 0.5336 |
54662 | TBC1D13 | HCC2 | Human | Liver | HCC | 9.62e-03 | 3.49e+00 | 0.5341 |
54662 | TBC1D13 | HCC5 | Human | Liver | HCC | 8.77e-03 | 1.61e+00 | 0.4932 |
54662 | TBC1D13 | S014 | Human | Liver | HCC | 5.31e-06 | 2.36e-01 | 0.2254 |
54662 | TBC1D13 | S015 | Human | Liver | HCC | 8.66e-11 | 4.14e-01 | 0.2375 |
54662 | TBC1D13 | S016 | Human | Liver | HCC | 1.65e-07 | 2.39e-01 | 0.2243 |
54662 | TBC1D13 | S028 | Human | Liver | HCC | 6.05e-07 | 3.20e-01 | 0.2503 |
54662 | TBC1D13 | S029 | Human | Liver | HCC | 1.74e-09 | 3.77e-01 | 0.2581 |
Page: 1 |
![]() |
Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TBC1D13 | SNV | Missense_Mutation | c.352G>A | p.Glu118Lys | p.E118K | Q9NVG8 | protein_coding | tolerated(0.1) | benign(0.234) | TCGA-A8-A09Z-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
TBC1D13 | SNV | Missense_Mutation | c.130N>C | p.Cys44Arg | p.C44R | Q9NVG8 | protein_coding | deleterious(0) | probably_damaging(0.926) | TCGA-AR-A256-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | PD | |
TBC1D13 | SNV | Missense_Mutation | c.1013N>C | p.Trp338Ser | p.W338S | Q9NVG8 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-E9-A243-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | 5-fluorouracil | PD | |
TBC1D13 | SNV | Missense_Mutation | c.342C>G | p.Phe114Leu | p.F114L | Q9NVG8 | protein_coding | deleterious(0) | probably_damaging(0.983) | TCGA-JW-A5VL-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
TBC1D13 | SNV | Missense_Mutation | c.314A>T | p.Asn105Ile | p.N105I | Q9NVG8 | protein_coding | deleterious(0) | possibly_damaging(0.861) | TCGA-4T-AA8H-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
TBC1D13 | SNV | Missense_Mutation | c.485T>C | p.Val162Ala | p.V162A | Q9NVG8 | protein_coding | deleterious(0) | probably_damaging(0.983) | TCGA-AA-A022-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
TBC1D13 | SNV | Missense_Mutation | novel | c.1087C>T | p.Arg363Trp | p.R363W | Q9NVG8 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AZ-4313-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TBC1D13 | SNV | Missense_Mutation | c.935N>C | p.Lys312Thr | p.K312T | Q9NVG8 | protein_coding | deleterious(0.05) | possibly_damaging(0.735) | TCGA-CA-6718-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | PD | |
TBC1D13 | SNV | Missense_Mutation | rs768723863 | c.1078A>G | p.Met360Val | p.M360V | Q9NVG8 | protein_coding | tolerated(1) | benign(0) | TCGA-WS-AB45-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TBC1D13 | SNV | Missense_Mutation | c.352G>A | p.Glu118Lys | p.E118K | Q9NVG8 | protein_coding | tolerated(0.1) | benign(0.234) | TCGA-AF-A56L-01 | Colorectum | rectum adenocarcinoma | Female | <65 | III/IV | Chemotherapy | oxaliplatin | CR |
Page: 1 2 3 4 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |