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Gene: TANGO2 |
Gene summary for TANGO2 |
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Gene information | Species | Human | Gene symbol | TANGO2 | Gene ID | 128989 |
Gene name | transport and golgi organization 2 homolog | |
Gene Alias | C22orf25 | |
Cytomap | 22q11.21 | |
Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | A8K1E7 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
128989 | TANGO2 | LZE24T | Human | Esophagus | ESCC | 1.56e-07 | 2.02e-01 | 0.0596 |
128989 | TANGO2 | LZE21T | Human | Esophagus | ESCC | 4.54e-02 | 1.66e-01 | 0.0655 |
128989 | TANGO2 | P2T-E | Human | Esophagus | ESCC | 5.08e-05 | 1.19e-01 | 0.1177 |
128989 | TANGO2 | P4T-E | Human | Esophagus | ESCC | 4.26e-07 | 1.80e-01 | 0.1323 |
128989 | TANGO2 | P5T-E | Human | Esophagus | ESCC | 6.72e-14 | 2.59e-01 | 0.1327 |
128989 | TANGO2 | P8T-E | Human | Esophagus | ESCC | 5.24e-07 | 1.52e-01 | 0.0889 |
128989 | TANGO2 | P9T-E | Human | Esophagus | ESCC | 1.83e-04 | 1.32e-01 | 0.1131 |
128989 | TANGO2 | P10T-E | Human | Esophagus | ESCC | 1.97e-17 | 3.23e-01 | 0.116 |
128989 | TANGO2 | P11T-E | Human | Esophagus | ESCC | 1.41e-08 | 3.46e-01 | 0.1426 |
128989 | TANGO2 | P12T-E | Human | Esophagus | ESCC | 4.75e-07 | 1.65e-01 | 0.1122 |
128989 | TANGO2 | P15T-E | Human | Esophagus | ESCC | 9.29e-04 | 1.12e-01 | 0.1149 |
128989 | TANGO2 | P16T-E | Human | Esophagus | ESCC | 2.89e-09 | 1.31e-01 | 0.1153 |
128989 | TANGO2 | P17T-E | Human | Esophagus | ESCC | 7.49e-05 | 2.53e-01 | 0.1278 |
128989 | TANGO2 | P19T-E | Human | Esophagus | ESCC | 1.21e-06 | 3.28e-01 | 0.1662 |
128989 | TANGO2 | P20T-E | Human | Esophagus | ESCC | 4.73e-09 | 2.45e-01 | 0.1124 |
128989 | TANGO2 | P21T-E | Human | Esophagus | ESCC | 1.40e-50 | 1.08e+00 | 0.1617 |
128989 | TANGO2 | P22T-E | Human | Esophagus | ESCC | 9.55e-09 | 2.17e-01 | 0.1236 |
128989 | TANGO2 | P23T-E | Human | Esophagus | ESCC | 1.91e-15 | 3.65e-01 | 0.108 |
128989 | TANGO2 | P24T-E | Human | Esophagus | ESCC | 1.76e-08 | 2.65e-01 | 0.1287 |
128989 | TANGO2 | P26T-E | Human | Esophagus | ESCC | 1.96e-07 | 1.81e-01 | 0.1276 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00070308 | Esophagus | ESCC | Golgi organization | 101/8552 | 157/18723 | 1.78e-06 | 2.10e-05 | 101 |
GO:000930617 | Esophagus | ESCC | protein secretion | 190/8552 | 359/18723 | 3.22e-03 | 1.34e-02 | 190 |
GO:003559217 | Esophagus | ESCC | establishment of protein localization to extracellular region | 190/8552 | 360/18723 | 3.77e-03 | 1.53e-02 | 190 |
GO:007169210 | Esophagus | ESCC | protein localization to extracellular region | 193/8552 | 368/18723 | 5.01e-03 | 1.92e-02 | 193 |
GO:00070302 | Liver | HCC | Golgi organization | 99/7958 | 157/18723 | 1.54e-07 | 2.85e-06 | 99 |
GO:003559212 | Liver | HCC | establishment of protein localization to extracellular region | 176/7958 | 360/18723 | 7.96e-03 | 3.15e-02 | 176 |
GO:000930612 | Liver | HCC | protein secretion | 175/7958 | 359/18723 | 9.32e-03 | 3.57e-02 | 175 |
GO:00070307 | Oral cavity | OSCC | Golgi organization | 92/7305 | 157/18723 | 4.96e-07 | 7.27e-06 | 92 |
GO:000930610 | Oral cavity | OSCC | protein secretion | 169/7305 | 359/18723 | 1.04e-03 | 5.34e-03 | 169 |
GO:003559210 | Oral cavity | OSCC | establishment of protein localization to extracellular region | 169/7305 | 360/18723 | 1.21e-03 | 6.08e-03 | 169 |
GO:00716929 | Oral cavity | OSCC | protein localization to extracellular region | 172/7305 | 368/18723 | 1.40e-03 | 6.79e-03 | 172 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TANGO2 | deletion | Frame_Shift_Del | novel | c.202delG | p.Asp68MetfsTer10 | p.D68Mfs*10 | Q6ICL3 | protein_coding | TCGA-EW-A2FV-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | docetaxel | SD | ||
TANGO2 | deletion | Frame_Shift_Del | novel | c.448delG | p.Val150SerfsTer14 | p.V150Sfs*14 | Q6ICL3 | protein_coding | TCGA-EW-A2FV-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | docetaxel | SD | ||
TANGO2 | SNV | Missense_Mutation | novel | c.739N>C | p.Asp247His | p.D247H | Q6ICL3 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-C5-A8YR-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | PD |
TANGO2 | SNV | Missense_Mutation | rs764219300 | c.380N>A | p.Arg127Gln | p.R127Q | Q6ICL3 | protein_coding | tolerated(0.4) | benign(0.024) | TCGA-IR-A3LA-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
TANGO2 | SNV | Missense_Mutation | c.856N>A | p.Asp286Asn | p.D286N | Q6ICL3 | protein_coding | tolerated(0.16) | probably_damaging(0.936) | TCGA-IR-A3LL-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
TANGO2 | SNV | Missense_Mutation | c.521N>C | p.Val174Ala | p.V174A | Q6ICL3 | protein_coding | tolerated(0.14) | benign(0.171) | TCGA-A6-3809-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
TANGO2 | SNV | Missense_Mutation | c.610C>A | p.Pro204Thr | p.P204T | Q6ICL3 | protein_coding | deleterious(0.01) | probably_damaging(0.996) | TCGA-A6-4107-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Chemotherapy | 5 | SD | |
TANGO2 | SNV | Missense_Mutation | rs760638813 | c.860C>T | p.Ala287Val | p.A287V | Q6ICL3 | protein_coding | tolerated(0.25) | benign(0.027) | TCGA-AA-3672-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
TANGO2 | SNV | Missense_Mutation | rs145876553 | c.520G>A | p.Val174Ile | p.V174I | Q6ICL3 | protein_coding | tolerated(0.35) | benign(0.027) | TCGA-AD-6964-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | folfox | PD |
TANGO2 | SNV | Missense_Mutation | rs776320425 | c.122N>T | p.Ala41Val | p.A41V | Q6ICL3 | protein_coding | deleterious_low_confidence(0.04) | benign(0.006) | TCGA-A5-A0VQ-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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