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Gene: TAF1B |
Gene summary for TAF1B |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | TAF1B | Gene ID | 9014 |
| Gene name | TATA-box binding protein associated factor, RNA polymerase I subunit B | |
| Gene Alias | MGC:9349 | |
| Cytomap | 2p25.1 | |
| Gene Type | protein-coding | GO ID | GO:0001188 | UniProtAcc | Q53T94 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 9014 | TAF1B | LZE2T | Human | Esophagus | ESCC | 8.14e-03 | 3.81e-01 | 0.082 |
| 9014 | TAF1B | LZE4T | Human | Esophagus | ESCC | 8.99e-17 | 3.72e-01 | 0.0811 |
| 9014 | TAF1B | LZE7T | Human | Esophagus | ESCC | 1.06e-05 | 2.15e-01 | 0.0667 |
| 9014 | TAF1B | LZE20T | Human | Esophagus | ESCC | 3.43e-02 | 1.19e-01 | 0.0662 |
| 9014 | TAF1B | LZE24T | Human | Esophagus | ESCC | 7.26e-05 | 1.85e-01 | 0.0596 |
| 9014 | TAF1B | LZE21T | Human | Esophagus | ESCC | 7.16e-12 | 3.32e-01 | 0.0655 |
| 9014 | TAF1B | P1T-E | Human | Esophagus | ESCC | 3.78e-04 | 1.88e-01 | 0.0875 |
| 9014 | TAF1B | P2T-E | Human | Esophagus | ESCC | 3.43e-46 | 8.08e-01 | 0.1177 |
| 9014 | TAF1B | P4T-E | Human | Esophagus | ESCC | 4.73e-22 | 5.31e-01 | 0.1323 |
| 9014 | TAF1B | P5T-E | Human | Esophagus | ESCC | 2.15e-14 | 2.51e-01 | 0.1327 |
| 9014 | TAF1B | P8T-E | Human | Esophagus | ESCC | 5.74e-13 | 2.55e-01 | 0.0889 |
| 9014 | TAF1B | P9T-E | Human | Esophagus | ESCC | 1.50e-18 | 3.62e-01 | 0.1131 |
| 9014 | TAF1B | P10T-E | Human | Esophagus | ESCC | 2.80e-45 | 7.54e-01 | 0.116 |
| 9014 | TAF1B | P11T-E | Human | Esophagus | ESCC | 2.75e-11 | 3.81e-01 | 0.1426 |
| 9014 | TAF1B | P12T-E | Human | Esophagus | ESCC | 3.42e-24 | 5.37e-01 | 0.1122 |
| 9014 | TAF1B | P15T-E | Human | Esophagus | ESCC | 8.44e-16 | 2.66e-01 | 0.1149 |
| 9014 | TAF1B | P16T-E | Human | Esophagus | ESCC | 5.43e-16 | 2.47e-01 | 0.1153 |
| 9014 | TAF1B | P17T-E | Human | Esophagus | ESCC | 1.34e-07 | 3.39e-01 | 0.1278 |
| 9014 | TAF1B | P19T-E | Human | Esophagus | ESCC | 9.72e-06 | 4.29e-01 | 0.1662 |
| 9014 | TAF1B | P20T-E | Human | Esophagus | ESCC | 2.07e-15 | 3.51e-01 | 0.1124 |
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| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias | ||
| Liver |  | HCC: Hepatocellular carcinoma |
| NAFLD: Non-alcoholic fatty liver disease | ||
| Oral Cavity |  | EOLP: Erosive Oral lichen planus |
| LP: leukoplakia | ||
| NEOLP: Non-erosive oral lichen planus | ||
| OSCC: Oral squamous cell carcinoma | ||
| Skin |  | AK: Actinic keratosis |
| cSCC: Cutaneous squamous cell carcinoma | ||
| SCCIS:squamous cell carcinoma in situ | ||
| Thyroid |  | ATC: Anaplastic thyroid cancer |
| HT: Hashimoto's thyroiditis | ||
| PTC: Papillary thyroid cancer |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:00987812 | Esophagus | ESCC | ncRNA transcription | 45/8552 | 56/18723 | 1.05e-07 | 1.72e-06 | 45 |
| GO:000635211 | Esophagus | ESCC | DNA-templated transcription, initiation | 86/8552 | 130/18723 | 1.88e-06 | 2.19e-05 | 86 |
| GO:00063602 | Esophagus | ESCC | transcription by RNA polymerase I | 42/8552 | 55/18723 | 3.41e-06 | 3.78e-05 | 42 |
| GO:00708973 | Esophagus | ESCC | transcription preinitiation complex assembly | 30/8552 | 36/18723 | 3.60e-06 | 3.95e-05 | 30 |
| GO:00093032 | Esophagus | ESCC | rRNA transcription | 28/8552 | 34/18723 | 1.21e-05 | 1.12e-04 | 28 |
| GO:00427902 | Esophagus | ESCC | nucleolar large rRNA transcription by RNA polymerase I | 15/8552 | 18/18723 | 1.20e-03 | 5.88e-03 | 15 |
| GO:00063611 | Esophagus | ESCC | transcription initiation from RNA polymerase I promoter | 11/8552 | 13/18723 | 4.76e-03 | 1.85e-02 | 11 |
| GO:0006352 | Liver | HCC | DNA-templated transcription, initiation | 78/7958 | 130/18723 | 4.19e-05 | 4.11e-04 | 78 |
| GO:0009303 | Liver | HCC | rRNA transcription | 25/7958 | 34/18723 | 2.42e-04 | 1.81e-03 | 25 |
| GO:0006360 | Liver | HCC | transcription by RNA polymerase I | 36/7958 | 55/18723 | 4.94e-04 | 3.23e-03 | 36 |
| GO:00708971 | Liver | HCC | transcription preinitiation complex assembly | 25/7958 | 36/18723 | 9.87e-04 | 5.71e-03 | 25 |
| GO:0098781 | Liver | HCC | ncRNA transcription | 33/7958 | 56/18723 | 9.64e-03 | 3.63e-02 | 33 |
| GO:0042790 | Liver | HCC | nucleolar large rRNA transcription by RNA polymerase I | 13/7958 | 18/18723 | 1.05e-02 | 3.89e-02 | 13 |
| GO:00987811 | Oral cavity | OSCC | ncRNA transcription | 38/7305 | 56/18723 | 1.15e-05 | 1.18e-04 | 38 |
| GO:00063522 | Oral cavity | OSCC | DNA-templated transcription, initiation | 74/7305 | 130/18723 | 2.56e-05 | 2.39e-04 | 74 |
| GO:00063601 | Oral cavity | OSCC | transcription by RNA polymerase I | 36/7305 | 55/18723 | 6.42e-05 | 5.22e-04 | 36 |
| GO:00093031 | Oral cavity | OSCC | rRNA transcription | 24/7305 | 34/18723 | 1.89e-04 | 1.28e-03 | 24 |
| GO:00708972 | Oral cavity | OSCC | transcription preinitiation complex assembly | 24/7305 | 36/18723 | 7.18e-04 | 3.95e-03 | 24 |
| GO:00427901 | Oral cavity | OSCC | nucleolar large rRNA transcription by RNA polymerase I | 14/7305 | 18/18723 | 9.51e-04 | 4.96e-03 | 14 |
| GO:0006361 | Oral cavity | NEOLP | transcription initiation from RNA polymerase I promoter | 5/2005 | 13/18723 | 8.62e-03 | 4.15e-02 | 5 |
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| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| TAF1B | SNV | Missense_Mutation | rs150786470 | c.602N>A | p.Arg201Gln | p.R201Q | Q53T94 | protein_coding | tolerated(0.2) | benign(0.003) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| TAF1B | SNV | Missense_Mutation | novel | c.478N>T | p.Leu160Phe | p.L160F | Q53T94 | protein_coding | tolerated(0.62) | benign(0.216) | TCGA-B6-A0IK-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | PD |
| TAF1B | SNV | Missense_Mutation | c.1063G>A | p.Asp355Asn | p.D355N | Q53T94 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-E2-A152-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Targeted Molecular therapy | trastuzumab | PD | |
| TAF1B | SNV | Missense_Mutation | novel | c.606G>T | p.Lys202Asn | p.K202N | Q53T94 | protein_coding | tolerated(0.42) | benign(0.038) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
| TAF1B | SNV | Missense_Mutation | c.166N>C | p.Lys56Gln | p.K56Q | Q53T94 | protein_coding | tolerated(1) | benign(0) | TCGA-JW-A5VJ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | PD | |
| TAF1B | deletion | Frame_Shift_Del | c.834delN | p.Tyr278Ter | p.Y278* | Q53T94 | protein_coding | TCGA-VS-A9UJ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | PD | |||
| TAF1B | SNV | Missense_Mutation | novel | c.647C>T | p.Ala216Val | p.A216V | Q53T94 | protein_coding | deleterious(0) | probably_damaging(0.941) | TCGA-AD-6895-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
| TAF1B | SNV | Missense_Mutation | novel | c.1551N>T | p.Gln517His | p.Q517H | Q53T94 | protein_coding | tolerated(0.36) | benign(0.007) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
| TAF1B | SNV | Missense_Mutation | c.532N>A | p.Val178Ile | p.V178I | Q53T94 | protein_coding | tolerated(0.93) | benign(0) | TCGA-NH-A5IV-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
| TAF1B | deletion | Frame_Shift_Del | c.834delN | p.Tyr278Ter | p.Y278* | Q53T94 | protein_coding | TCGA-AA-3715-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
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