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Gene: TAF1A |
Gene summary for TAF1A |
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Gene information | Species | Human | Gene symbol | TAF1A | Gene ID | 9015 |
Gene name | TATA-box binding protein associated factor, RNA polymerase I subunit A | |
Gene Alias | MGC:17061 | |
Cytomap | 1q41 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | A8K4K5 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
9015 | TAF1A | HCC1_Meng | Human | Liver | HCC | 5.14e-23 | 2.88e-02 | 0.0246 |
9015 | TAF1A | HCC2_Meng | Human | Liver | HCC | 6.18e-03 | 1.38e-02 | 0.0107 |
9015 | TAF1A | HCC1 | Human | Liver | HCC | 3.49e-08 | 1.90e+00 | 0.5336 |
9015 | TAF1A | HCC2 | Human | Liver | HCC | 6.45e-18 | 2.23e+00 | 0.5341 |
9015 | TAF1A | HCC5 | Human | Liver | HCC | 1.40e-12 | 1.20e+00 | 0.4932 |
9015 | TAF1A | S015 | Human | Liver | HCC | 1.11e-04 | 2.08e-01 | 0.2375 |
9015 | TAF1A | S016 | Human | Liver | HCC | 2.88e-03 | 1.77e-01 | 0.2243 |
9015 | TAF1A | S029 | Human | Liver | HCC | 2.46e-02 | 2.05e-01 | 0.2581 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0006360 | Liver | HCC | transcription by RNA polymerase I | 36/7958 | 55/18723 | 4.94e-04 | 3.23e-03 | 36 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TAF1A | SNV | Missense_Mutation | c.223G>C | p.Glu75Gln | p.E75Q | Q15573 | protein_coding | deleterious(0.05) | possibly_damaging(0.714) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
TAF1A | SNV | Missense_Mutation | rs532821908 | c.370N>T | p.Arg124Trp | p.R124W | Q15573 | protein_coding | deleterious(0) | probably_damaging(0.917) | TCGA-AO-A0JA-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Hormone Therapy | leuprolide | SD |
TAF1A | SNV | Missense_Mutation | c.665C>T | p.Thr222Ile | p.T222I | Q15573 | protein_coding | deleterious(0) | possibly_damaging(0.463) | TCGA-BH-A18G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
TAF1A | SNV | Missense_Mutation | c.439N>T | p.His147Tyr | p.H147Y | Q15573 | protein_coding | tolerated(0.1) | benign(0.048) | TCGA-D8-A27G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
TAF1A | insertion | Frame_Shift_Ins | novel | c.193_194insGGCCTCCCAAAATCCTGGGATTACAGGT | p.Leu65ArgfsTer34 | p.L65Rfs*34 | Q15573 | protein_coding | TCGA-A8-A07J-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | 5-fluorouracil | CR | ||
TAF1A | SNV | Missense_Mutation | novel | c.1057G>T | p.Ala353Ser | p.A353S | Q15573 | protein_coding | deleterious(0.04) | benign(0.067) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
TAF1A | SNV | Missense_Mutation | novel | c.109N>T | p.Val37Leu | p.V37L | Q15573 | protein_coding | tolerated(1) | benign(0) | TCGA-ZJ-AAX4-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Unknown | Unknown | SD |
TAF1A | SNV | Missense_Mutation | c.522N>G | p.Ile174Met | p.I174M | Q15573 | protein_coding | tolerated(0.11) | benign(0.005) | TCGA-AA-3492-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
TAF1A | SNV | Missense_Mutation | c.1219N>A | p.Ala407Thr | p.A407T | Q15573 | protein_coding | tolerated(0.09) | possibly_damaging(0.651) | TCGA-AA-3875-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
TAF1A | SNV | Missense_Mutation | c.290N>G | p.Glu97Gly | p.E97G | Q15573 | protein_coding | deleterious(0) | probably_damaging(0.943) | TCGA-CA-6718-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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