Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: TAF15

Gene summary for TAF15

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

TAF15

Gene ID

8148

Gene nameTATA-box binding protein associated factor 15
Gene AliasNpl3
Cytomap17q12
Gene Typeprotein-coding
GO ID

GO:0006139

UniProtAcc

Q92804


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
8148TAF15CA_HPV_2HumanCervixCC2.23e-032.24e-010.0391
8148TAF15CA_HPV_3HumanCervixCC1.07e-072.28e-010.0414
8148TAF15CCI_1HumanCervixCC7.38e-047.60e-010.528
8148TAF15CCI_2HumanCervixCC2.04e-058.18e-010.5249
8148TAF15CCI_3HumanCervixCC1.58e-117.90e-010.516
8148TAF15T3HumanCervixCC3.17e-021.37e-010.1389
8148TAF15HTA11_3410_2000001011HumanColorectumAD5.48e-17-5.67e-010.0155
8148TAF15HTA11_2487_2000001011HumanColorectumSER1.25e-03-4.81e-01-0.1808
8148TAF15HTA11_2951_2000001011HumanColorectumAD3.17e-03-8.24e-010.0216
8148TAF15HTA11_696_2000001011HumanColorectumAD8.05e-12-4.73e-01-0.1464
8148TAF15HTA11_866_2000001011HumanColorectumAD5.17e-06-4.02e-01-0.1001
8148TAF15HTA11_5212_2000001011HumanColorectumAD2.60e-02-6.32e-01-0.2061
8148TAF15HTA11_546_2000001011HumanColorectumAD2.04e-02-2.31e-01-0.0842
8148TAF15HTA11_7862_2000001011HumanColorectumAD1.80e-02-5.35e-01-0.0179
8148TAF15HTA11_866_3004761011HumanColorectumAD9.39e-07-5.31e-010.096
8148TAF15HTA11_10623_2000001011HumanColorectumAD2.03e-02-4.21e-01-0.0177
8148TAF15HTA11_6818_2000001021HumanColorectumAD3.71e-03-3.15e-010.0588
8148TAF15HTA11_99999970781_79442HumanColorectumMSS6.78e-05-2.49e-010.294
8148TAF15HTA11_99999971662_82457HumanColorectumMSS3.60e-02-3.16e-010.3859
8148TAF15HTA11_99999974143_84620HumanColorectumMSS7.72e-07-3.64e-010.3005
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
CervixThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.CC: Cervix cancer
HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions
N_HPV: HPV-infected normal cervix
Colorectum (GSE201348)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.FAP: Familial adenomatous polyposis
CRC: Colorectal cancer
Colorectum (HTA11)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AD: Adenomas
SER: Sessile serrated lesions
MSI-H: Microsatellite-high colorectal cancer
MSS: Microsatellite stable colorectal cancer
EsophagusThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ESCC: Esophageal squamous cell carcinoma
HGIN: High-grade intraepithelial neoplasias
LGIN: Low-grade intraepithelial neoplasias
LiverThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.HCC: Hepatocellular carcinoma
NAFLD: Non-alcoholic fatty liver disease
LungThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AAH: Atypical adenomatous hyperplasia
AIS: Adenocarcinoma in situ
IAC: Invasive lung adenocarcinoma
MIA: Minimally invasive adenocarcinoma
Oral CavityThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.EOLP: Erosive Oral lichen planus
LP: leukoplakia
NEOLP: Non-erosive oral lichen planus
OSCC: Oral squamous cell carcinoma
ProstateThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.BPH: Benign Prostatic Hyperplasia
SkinThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AK: Actinic keratosis
cSCC: Cutaneous squamous cell carcinoma
SCCIS:squamous cell carcinoma in situ
ThyroidThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ATC: Anaplastic thyroid cancer
HT: Hashimoto's thyroiditis
PTC: Papillary thyroid cancer
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:003133010CervixCCnegative regulation of cellular catabolic process63/2311262/187231.10e-075.68e-0663
GO:00064029CervixCCmRNA catabolic process56/2311232/187234.81e-071.83e-0556
GO:19033119CervixCCregulation of mRNA metabolic process64/2311288/187231.71e-065.64e-0564
GO:000989510CervixCCnegative regulation of catabolic process69/2311320/187232.15e-066.55e-0569
GO:00064019CervixCCRNA catabolic process62/2311278/187232.18e-066.56e-0562
GO:00610139CervixCCregulation of mRNA catabolic process38/2311166/187231.07e-041.36e-0338
GO:190331210CervixCCnegative regulation of mRNA metabolic process24/231192/187232.49e-042.77e-0324
GO:00467008CervixCCheterocycle catabolic process80/2311445/187233.23e-043.42e-0380
GO:00346559CervixCCnucleobase-containing compound catabolic process74/2311407/187233.77e-043.88e-0374
GO:00434889CervixCCregulation of mRNA stability35/2311158/187233.80e-043.89e-0335
GO:00434879CervixCCregulation of RNA stability36/2311170/187237.72e-046.86e-0336
GO:00442709CervixCCcellular nitrogen compound catabolic process79/2311451/187237.80e-046.91e-0379
GO:19023698CervixCCnegative regulation of RNA catabolic process19/231175/187231.54e-031.19e-0219
GO:00194398CervixCCaromatic compound catabolic process79/2311467/187232.14e-031.54e-0279
GO:19013618CervixCCorganic cyclic compound catabolic process80/2311495/187236.77e-033.72e-0280
GO:19023738CervixCCnegative regulation of mRNA catabolic process15/231163/187238.52e-034.40e-0215
GO:1903311ColorectumADregulation of mRNA metabolic process117/3918288/187231.69e-144.23e-12117
GO:0009895ColorectumADnegative regulation of catabolic process124/3918320/187231.66e-133.35e-11124
GO:0031330ColorectumADnegative regulation of cellular catabolic process104/3918262/187232.66e-123.96e-10104
GO:0006401ColorectumADRNA catabolic process102/3918278/187238.64e-106.76e-08102
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
hsa05202ColorectumFAPTranscriptional misregulation in cancer45/1404193/84659.19e-033.33e-022.03e-0245
hsa052021ColorectumFAPTranscriptional misregulation in cancer45/1404193/84659.19e-033.33e-022.03e-0245
hsa030222EsophagusESCCBasal transcription factors35/420545/84651.01e-044.06e-042.08e-0435
hsa052028EsophagusESCCTranscriptional misregulation in cancer116/4205193/84652.08e-035.95e-033.05e-03116
hsa0302211EsophagusESCCBasal transcription factors35/420545/84651.01e-044.06e-042.08e-0435
hsa0520213EsophagusESCCTranscriptional misregulation in cancer116/4205193/84652.08e-035.95e-033.05e-03116
hsa052026LungIACTranscriptional misregulation in cancer40/1053193/84656.90e-045.90e-033.92e-0340
hsa0520211LungIACTranscriptional misregulation in cancer40/1053193/84656.90e-045.90e-033.92e-0340
hsa052022LungAISTranscriptional misregulation in cancer39/961193/84652.15e-042.41e-031.54e-0339
hsa052023LungAISTranscriptional misregulation in cancer39/961193/84652.15e-042.41e-031.54e-0339
hsa052024LungMIACTranscriptional misregulation in cancer22/507193/84652.64e-032.26e-021.64e-0222
hsa052025LungMIACTranscriptional misregulation in cancer22/507193/84652.64e-032.26e-021.64e-0222
hsa03022Oral cavityOSCCBasal transcription factors28/370445/84659.53e-032.11e-021.08e-0228
hsa030221Oral cavityOSCCBasal transcription factors28/370445/84659.53e-032.11e-021.08e-0228
hsa052027ProstateBPHTranscriptional misregulation in cancer53/1718193/84659.56e-032.92e-021.81e-0253
hsa0520212ProstateBPHTranscriptional misregulation in cancer53/1718193/84659.56e-032.92e-021.81e-0253
hsa0520221ProstateTumorTranscriptional misregulation in cancer59/1791193/84651.22e-035.26e-033.26e-0359
hsa0520231ProstateTumorTranscriptional misregulation in cancer59/1791193/84651.22e-035.26e-033.26e-0359
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
TAF15SNVMissense_Mutationnovelc.1270N>Tp.Gly424Trpp.G424WQ92804protein_codingdeleterious_low_confidence(0.04)possibly_damaging(0.525)TCGA-A7-A0DB-01Breastbreast invasive carcinomaFemale<65I/IIHormone TherapyarimidexSD
TAF15insertionFrame_Shift_Insnovelc.566_567insACTCAGCTCTTGTGGCATGTTTATTAAAGAGTCAGACp.Tyr190LeufsTer14p.Y190Lfs*14Q92804protein_codingTCGA-A8-A08H-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownSD
TAF15insertionFrame_Shift_Insrs770087298c.1582_1583insGp.Tyr531LeufsTer56p.Y531Lfs*56Q92804protein_codingTCGA-BH-A1FD-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownPD
TAF15SNVMissense_Mutationrs746865431c.1246N>Ap.Gly416Serp.G416SQ92804protein_codingdeleterious_low_confidence(0.05)benign(0.183)TCGA-2W-A8YY-01Cervixcervical & endocervical cancerFemale<65I/IIChemotherapycisplatinCR
TAF15SNVMissense_Mutationnovelc.962N>Tp.Arg321Ilep.R321IQ92804protein_codingdeleterious_low_confidence(0)probably_damaging(0.967)TCGA-JX-A3Q8-01Cervixcervical & endocervical cancerFemale<65I/IIUnknownUnknownSD
TAF15SNVMissense_Mutationnovelc.1510G>Cp.Asp504Hisp.D504HQ92804protein_codingdeleterious_low_confidence(0)possibly_damaging(0.907)TCGA-LP-A5U2-01Cervixcervical & endocervical cancerFemale<65III/IVUnknownUnknownSD
TAF15SNVMissense_Mutationnovelc.1752N>Tp.Arg584Serp.R584SQ92804protein_codingdeleterious_low_confidence(0)probably_damaging(0.95)TCGA-UC-A7PF-01Cervixcervical & endocervical cancerFemale<65I/IIUnknownUnknownSD
TAF15SNVMissense_Mutationrs780771102c.535N>Ap.Gly179Argp.G179RQ92804protein_codingtolerated_low_confidence(0.06)probably_damaging(0.999)TCGA-A6-6781-01Colorectumcolon adenocarcinomaMale<65III/IVChemotherapyoxaliplatinSD
TAF15SNVMissense_Mutationnovelc.1469G>Ap.Arg490Glnp.R490QQ92804protein_codingbenign(0.003)TCGA-AA-A01K-01Colorectumcolon adenocarcinomaFemale>=65III/IVChemotherapyfolinicCR
TAF15SNVMissense_Mutationrs770549195c.1358N>Ap.Gly453Aspp.G453DQ92804protein_codingdeleterious_low_confidence(0.01)benign(0.205)TCGA-AZ-6598-01Colorectumcolon adenocarcinomaFemale>=65I/IIUnknownUnknownSD
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
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