Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: SYNPO2L

Gene summary for SYNPO2L

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

SYNPO2L

Gene ID

79933

Gene namesynaptopodin 2 like
Gene AliasSYNPO2L
Cytomap10q22.2
Gene Typeprotein-coding
GO ID

GO:0003007

UniProtAcc

Q9H987


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
79933SYNPO2LHCC1HumanLiverHCC1.22e-081.25e+000.5336
79933SYNPO2LHCC2HumanLiverHCC6.34e-139.55e-010.5341
79933SYNPO2LHCC5HumanLiverHCC1.23e-111.05e+000.4932
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
LiverThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.HCC: Hepatocellular carcinoma
NAFLD: Non-alcoholic fatty liver disease
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:190290322LiverHCCregulation of supramolecular fiber organization224/7958383/187231.54e-105.33e-09224
GO:000701522LiverHCCactin filament organization252/7958442/187233.83e-101.25e-08252
GO:190290522LiverHCCpositive regulation of supramolecular fiber organization131/7958209/187232.85e-097.69e-08131
GO:005149522LiverHCCpositive regulation of cytoskeleton organization138/7958226/187231.26e-083.12e-07138
GO:003297022LiverHCCregulation of actin filament-based process222/7958397/187233.81e-088.30e-07222
GO:003295622LiverHCCregulation of actin cytoskeleton organization202/7958358/187236.18e-081.29e-06202
GO:000726521LiverHCCRas protein signal transduction187/7958337/187238.89e-071.35e-05187
GO:011005322LiverHCCregulation of actin filament organization158/7958278/187239.01e-071.37e-05158
GO:005101722LiverHCCactin filament bundle assembly96/7958157/187231.81e-062.52e-0596
GO:006157222LiverHCCactin filament bundle organization97/7958161/187234.04e-065.22e-0597
GO:003103222LiverHCCactomyosin structure organization109/7958196/187231.39e-041.13e-03109
GO:000726621LiverHCCRho protein signal transduction76/7958137/187231.46e-037.75e-0376
GO:003003822LiverHCCcontractile actin filament bundle assembly60/7958106/187232.34e-031.16e-0260
GO:004314922LiverHCCstress fiber assembly60/7958106/187232.34e-031.16e-0260
GO:004657811LiverHCCregulation of Ras protein signal transduction100/7958189/187232.42e-031.18e-02100
GO:003223312LiverHCCpositive regulation of actin filament bundle assembly38/795863/187233.27e-031.50e-0238
GO:003223122LiverHCCregulation of actin filament bundle assembly57/7958105/187239.73e-033.66e-0257
GO:011002022LiverHCCregulation of actomyosin structure organization54/7958100/187231.33e-024.76e-0254
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
SYNPO2LSNVMissense_Mutationnovelc.1798N>Ap.Gly600Serp.G600SQ9H987protein_codingtolerated(0.97)benign(0)TCGA-A2-A0CL-01Breastbreast invasive carcinomaFemale<65III/IVChemotherapycytoxanSD
SYNPO2LSNVMissense_Mutationc.1183N>Tp.Arg395Cysp.R395CQ9H987protein_codingdeleterious(0)probably_damaging(0.988)TCGA-AO-A0JI-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapycyclophosphamideSD
SYNPO2LSNVMissense_Mutationc.874T>Cp.Ser292Prop.S292PQ9H987protein_codingdeleterious(0)probably_damaging(0.996)TCGA-AO-A128-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapydoxorubicinSD
SYNPO2LSNVMissense_Mutationc.2459N>Cp.Phe820Serp.F820SQ9H987protein_codingtolerated(0.37)benign(0.03)TCGA-AO-A1KP-01Breastbreast invasive carcinomaFemale>=65I/IIChemotherapyfluorouracilSD
SYNPO2LinsertionFrame_Shift_Insnovelc.2184_2185insTGp.Pro729CysfsTer12p.P729Cfs*12Q9H987protein_codingTCGA-A8-A079-01Breastbreast invasive carcinomaFemale>=65III/IVChemotherapy5-fluorouracilSD
SYNPO2LinsertionFrame_Shift_Insnovelc.2182_2183insGCCTGTCTTCACCCACTCAGTCGTTTTGGGTACTCp.Lys728SerfsTer24p.K728Sfs*24Q9H987protein_codingTCGA-A8-A079-01Breastbreast invasive carcinomaFemale>=65III/IVChemotherapy5-fluorouracilSD
SYNPO2LSNVMissense_Mutationnovelc.413A>Gp.Tyr138Cysp.Y138CQ9H987protein_codingdeleterious(0)probably_damaging(0.998)TCGA-EA-A410-01Cervixcervical & endocervical cancerFemale<65I/IIUnknownUnknownSD
SYNPO2LSNVMissense_Mutationc.2870N>Ap.Arg957Glnp.R957QQ9H987protein_codingdeleterious(0.01)benign(0.267)TCGA-FU-A3HZ-01Cervixcervical & endocervical cancerFemale<65I/IIChemotherapycisplatinCR
SYNPO2LSNVMissense_Mutationnovelc.1072N>Ap.Asp358Asnp.D358NQ9H987protein_codingdeleterious(0.01)probably_damaging(0.981)TCGA-UC-A7PG-06Cervixcervical & endocervical cancerFemale<65III/IVChemotherapycisplatinPD
SYNPO2LdeletionIn_Frame_Delnovelc.2078_2086delNNNNNNNNNp.Arg693_Tyr695delp.R693_Y695delQ9H987protein_codingTCGA-DS-A1OB-01Cervixcervical & endocervical cancerFemale<65I/IIChemotherapycarboplatinPD
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
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