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Gene: SYCN |
Gene summary for SYCN |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | SYCN | Gene ID | 342898 |
| Gene name | syncollin | |
| Gene Alias | INSSA1 | |
| Cytomap | 19q13.2 | |
| Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | Q0VAF6 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 342898 | SYCN | HTA12-15-2 | Human | Pancreas | PDAC | 4.82e-42 | -2.28e+00 | 0.2315 |
| 342898 | SYCN | HTA12-23-1 | Human | Pancreas | PDAC | 3.25e-29 | -2.28e+00 | 0.3405 |
| 342898 | SYCN | HTA12-25-1 | Human | Pancreas | PDAC | 3.06e-41 | -2.28e+00 | 0.313 |
| 342898 | SYCN | HTA12-26-1 | Human | Pancreas | PDAC | 1.02e-49 | -2.28e+00 | 0.3728 |
| 342898 | SYCN | HTA12-29-1 | Human | Pancreas | PDAC | 8.03e-116 | -2.28e+00 | 0.3722 |
| 342898 | SYCN | HTA12-3-16 | Human | Pancreas | PDAC | 1.48e-09 | -2.28e+00 | 0.1553 |
| 342898 | SYCN | HTA12-30-1 | Human | Pancreas | PDAC | 9.92e-11 | -2.28e+00 | 0.3671 |
| 342898 | SYCN | HTA12-32-1 | Human | Pancreas | PDAC | 3.10e-15 | -2.28e+00 | 0.3624 |
| 342898 | SYCN | HTA12-9-1 | Human | Pancreas | PDAC | 3.87e-64 | -2.21e+00 | 0.1532 |
| 342898 | SYCN | HTA12-9-2 | Human | Pancreas | PDAC | 2.01e-12 | -3.83e-01 | 0.0835 |
| 342898 | SYCN | HTA12-9-3 | Human | Pancreas | PDAC | 1.45e-34 | -2.28e+00 | 0.2045 |
| 342898 | SYCN | 3829-EC | Human | Pancreas | PanIN | 2.99e-58 | -6.66e-01 | 0.009 |
| 342898 | SYCN | 4347-EC | Human | Pancreas | PanIN | 5.06e-15 | -3.16e-01 | 0.0572 |
| 342898 | SYCN | 181429 | Human | Pancreas | PDAC | 1.92e-18 | -2.28e+00 | 0.1416 |
| 342898 | SYCN | 61354830 | Human | Pancreas | PDAC | 9.92e-11 | -2.28e+00 | 0.1458 |
| 342898 | SYCN | DS20191261Tumor | Human | Pancreas | PDAC | 6.16e-78 | -2.28e+00 | 0.1367 |
| 342898 | SYCN | DS20191261TumorKeller | Human | Pancreas | PDAC | 1.63e-23 | -2.28e+00 | 0.1407 |
| Page: 1 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| Page: 1 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| Page: 1 |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
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