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Gene: SWSAP1 |
Gene summary for SWSAP1 |
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Gene information | Species | Human | Gene symbol | SWSAP1 | Gene ID | 126074 |
Gene name | SWIM-type zinc finger 7 associated protein 1 | |
Gene Alias | C19orf39 | |
Cytomap | 19p13.2 | |
Gene Type | protein-coding | GO ID | GO:0000724 | UniProtAcc | Q6NVH7 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
126074 | SWSAP1 | HCC1_Meng | Human | Liver | HCC | 3.62e-13 | -1.45e-02 | 0.0246 |
126074 | SWSAP1 | HCC1 | Human | Liver | HCC | 5.57e-08 | 1.47e+00 | 0.5336 |
126074 | SWSAP1 | HCC2 | Human | Liver | HCC | 6.90e-13 | 1.01e+00 | 0.5341 |
126074 | SWSAP1 | HCC5 | Human | Liver | HCC | 1.87e-14 | 1.44e+00 | 0.4932 |
126074 | SWSAP1 | S015 | Human | Liver | HCC | 8.81e-04 | 1.76e-01 | 0.2375 |
126074 | SWSAP1 | S016 | Human | Liver | HCC | 1.95e-07 | 1.46e-01 | 0.2243 |
126074 | SWSAP1 | S029 | Human | Liver | HCC | 1.16e-03 | 1.64e-01 | 0.2581 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:003164722 | Liver | HCC | regulation of protein stability | 211/7958 | 298/18723 | 2.29e-23 | 5.01e-21 | 211 |
GO:005082122 | Liver | HCC | protein stabilization | 139/7958 | 191/18723 | 1.61e-17 | 1.71e-15 | 139 |
GO:00063021 | Liver | HCC | double-strand break repair | 131/7958 | 251/18723 | 1.17e-03 | 6.54e-03 | 131 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SWSAP1 | SNV | Missense_Mutation | c.223C>T | p.Leu75Phe | p.L75F | Q6NVH7 | protein_coding | tolerated(0.06) | probably_damaging(0.999) | TCGA-BH-A0AW-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | SD | |
SWSAP1 | SNV | Missense_Mutation | c.426N>C | p.Gln142His | p.Q142H | Q6NVH7 | protein_coding | deleterious(0.01) | possibly_damaging(0.541) | TCGA-EW-A1P4-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | docetaxel | SD | |
SWSAP1 | insertion | In_Frame_Ins | novel | c.115_116insGCA | p.Phe39delinsCysIle | p.F39delinsCI | Q6NVH7 | protein_coding | TCGA-A8-A07R-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Ancillary | zoledronic | SD | ||
SWSAP1 | insertion | In_Frame_Ins | novel | c.116_117insAGGTTCTAACCATTTGCCCATTCA | p.Phe39delinsLeuGlySerAsnHisLeuProIleHis | p.F39delinsLGSNHLPIH | Q6NVH7 | protein_coding | TCGA-A8-A07R-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Ancillary | zoledronic | SD | ||
SWSAP1 | SNV | Missense_Mutation | c.625N>T | p.Pro209Ser | p.P209S | Q6NVH7 | protein_coding | tolerated(0.12) | benign(0.011) | TCGA-DR-A0ZM-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unspecific | Cisplatin | SD | |
SWSAP1 | SNV | Missense_Mutation | novel | c.634N>T | p.Thr212Ser | p.T212S | Q6NVH7 | protein_coding | tolerated(0.78) | benign(0.027) | TCGA-DS-A1OD-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | SD |
SWSAP1 | insertion | In_Frame_Ins | novel | c.635_636insTCTTTCTGT | p.Thr212_Gln213insLeuSerVal | p.T212_Q213insLSV | Q6NVH7 | protein_coding | TCGA-DS-A1OD-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | SD | ||
SWSAP1 | SNV | Missense_Mutation | novel | c.631N>T | p.Pro211Ser | p.P211S | Q6NVH7 | protein_coding | tolerated(0.22) | benign(0.001) | TCGA-AZ-4313-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
SWSAP1 | SNV | Missense_Mutation | novel | c.383G>A | p.Arg128Gln | p.R128Q | Q6NVH7 | protein_coding | tolerated(0.07) | benign(0.066) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
SWSAP1 | SNV | Missense_Mutation | c.274N>A | p.Leu92Ile | p.L92I | Q6NVH7 | protein_coding | deleterious(0.01) | probably_damaging(0.998) | TCGA-AG-A02N-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | I/II | Chemotherapy | folinic | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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