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Gene: SVOP |
Gene summary for SVOP |
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Gene information | Species | Human | Gene symbol | SVOP | Gene ID | 55530 |
Gene name | SV2 related protein | |
Gene Alias | SVOP | |
Cytomap | 12q24.11 | |
Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | Q8N4V2 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
55530 | SVOP | HCC1 | Human | Liver | HCC | 4.28e-06 | 1.06e+00 | 0.5336 |
55530 | SVOP | HCC2 | Human | Liver | HCC | 5.19e-19 | 1.49e+00 | 0.5341 |
55530 | SVOP | HCC5 | Human | Liver | HCC | 8.16e-12 | 1.16e+00 | 0.4932 |
55530 | SVOP | HTA12-15-2 | Human | Pancreas | PDAC | 4.06e-02 | 2.54e-01 | 0.2315 |
55530 | SVOP | HTA12-23-1 | Human | Pancreas | PDAC | 1.44e-05 | 5.85e-01 | 0.3405 |
55530 | SVOP | HTA12-26-1 | Human | Pancreas | PDAC | 1.03e-14 | 6.65e-01 | 0.3728 |
55530 | SVOP | HTA12-29-1 | Human | Pancreas | PDAC | 5.28e-20 | 4.50e-01 | 0.3722 |
55530 | SVOP | HTA12-32-1 | Human | Pancreas | PDAC | 4.65e-02 | 5.67e-01 | 0.3624 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SVOP | SNV | Missense_Mutation | novel | c.868C>A | p.Pro290Thr | p.P290T | Q8N4V2 | protein_coding | deleterious(0.03) | probably_damaging(0.995) | TCGA-A2-A25A-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unspecific | Cytoxan | SD |
SVOP | SNV | Missense_Mutation | novel | c.1301G>A | p.Arg434Lys | p.R434K | Q8N4V2 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AN-A0AM-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
SVOP | SNV | Missense_Mutation | novel | c.1348G>A | p.Glu450Lys | p.E450K | Q8N4V2 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AN-A0XW-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
SVOP | SNV | Missense_Mutation | novel | c.269C>A | p.Thr90Asn | p.T90N | Q8N4V2 | protein_coding | deleterious(0.04) | benign(0.292) | TCGA-AR-A1AH-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unspecific | PD | |
SVOP | deletion | Frame_Shift_Del | novel | c.560delN | p.Ile187ThrfsTer8 | p.I187Tfs*8 | Q8N4V2 | protein_coding | TCGA-D8-A27V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | ||
SVOP | deletion | Frame_Shift_Del | novel | c.1030delN | p.Ala344GlnfsTer14 | p.A344Qfs*14 | Q8N4V2 | protein_coding | TCGA-EW-A2FV-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | docetaxel | SD | ||
SVOP | SNV | Missense_Mutation | novel | c.987N>G | p.Phe329Leu | p.F329L | Q8N4V2 | protein_coding | deleterious(0) | probably_damaging(0.919) | TCGA-IR-A3LK-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Chemotherapy | cisplatin | PD |
SVOP | SNV | Missense_Mutation | rs765709664 | c.1369C>T | p.Arg457Trp | p.R457W | Q8N4V2 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-A6-6654-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | oxaliplatin | SD |
SVOP | SNV | Missense_Mutation | rs747677894 | c.1427N>T | p.Pro476Leu | p.P476L | Q8N4V2 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-A6-A565-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Unspecific | 5FU | PD |
SVOP | SNV | Missense_Mutation | rs753922905 | c.1378N>A | p.Gly460Ser | p.G460S | Q8N4V2 | protein_coding | deleterious(0.01) | probably_damaging(0.996) | TCGA-AA-A022-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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