![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: SULT1E1 |
Gene summary for SULT1E1 |
![]() |
Gene information | Species | Human | Gene symbol | SULT1E1 | Gene ID | 6783 |
Gene name | sulfotransferase family 1E member 1 | |
Gene Alias | EST | |
Cytomap | 4q13.3 | |
Gene Type | protein-coding | GO ID | GO:0006066 | UniProtAcc | P49888 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
6783 | SULT1E1 | P10T-E | Human | Esophagus | ESCC | 1.98e-56 | 1.61e+00 | 0.116 |
6783 | SULT1E1 | P12T-E | Human | Esophagus | ESCC | 3.43e-19 | 7.19e-01 | 0.1122 |
6783 | SULT1E1 | P20T-E | Human | Esophagus | ESCC | 5.73e-03 | 1.70e-01 | 0.1124 |
6783 | SULT1E1 | P26T-E | Human | Esophagus | ESCC | 1.71e-03 | 3.31e-01 | 0.1276 |
6783 | SULT1E1 | P42T-E | Human | Esophagus | ESCC | 5.83e-09 | 3.56e-01 | 0.1175 |
6783 | SULT1E1 | P52T-E | Human | Esophagus | ESCC | 3.52e-05 | 1.81e-01 | 0.1555 |
6783 | SULT1E1 | P61T-E | Human | Esophagus | ESCC | 1.72e-13 | 4.02e-01 | 0.099 |
6783 | SULT1E1 | P74T-E | Human | Esophagus | ESCC | 2.11e-10 | 5.08e-01 | 0.1479 |
6783 | SULT1E1 | P76T-E | Human | Esophagus | ESCC | 1.57e-09 | 4.35e-01 | 0.1207 |
6783 | SULT1E1 | P79T-E | Human | Esophagus | ESCC | 5.69e-03 | 2.48e-01 | 0.1154 |
6783 | SULT1E1 | P107T-E | Human | Esophagus | ESCC | 8.98e-03 | 1.26e-01 | 0.171 |
Page: 1 |
![]() |
Tissue | Expression Dynamics | Abbreviation |
Esophagus | ![]() | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias | ||
LGIN: Low-grade intraepithelial neoplasias |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:190136118 | Esophagus | ESCC | organic cyclic compound catabolic process | 307/8552 | 495/18723 | 9.99e-14 | 4.80e-12 | 307 |
GO:0006753110 | Esophagus | ESCC | nucleoside phosphate metabolic process | 288/8552 | 497/18723 | 1.80e-08 | 3.50e-07 | 288 |
GO:0019693111 | Esophagus | ESCC | ribose phosphate metabolic process | 234/8552 | 396/18723 | 4.24e-08 | 7.76e-07 | 234 |
GO:0009117111 | Esophagus | ESCC | nucleotide metabolic process | 282/8552 | 489/18723 | 4.70e-08 | 8.50e-07 | 282 |
GO:00067906 | Esophagus | ESCC | sulfur compound metabolic process | 201/8552 | 339/18723 | 2.64e-07 | 3.94e-06 | 201 |
GO:0009259111 | Esophagus | ESCC | ribonucleotide metabolic process | 224/8552 | 385/18723 | 4.41e-07 | 6.00e-06 | 224 |
GO:0072521111 | Esophagus | ESCC | purine-containing compound metabolic process | 238/8552 | 416/18723 | 1.20e-06 | 1.49e-05 | 238 |
GO:0009150111 | Esophagus | ESCC | purine ribonucleotide metabolic process | 213/8552 | 368/18723 | 1.40e-06 | 1.69e-05 | 213 |
GO:0006163111 | Esophagus | ESCC | purine nucleotide metabolic process | 226/8552 | 396/18723 | 2.81e-06 | 3.21e-05 | 226 |
GO:00060668 | Esophagus | ESCC | alcohol metabolic process | 202/8552 | 353/18723 | 7.32e-06 | 7.26e-05 | 202 |
GO:00454449 | Esophagus | ESCC | fat cell differentiation | 135/8552 | 229/18723 | 3.38e-05 | 2.78e-04 | 135 |
GO:00456007 | Esophagus | ESCC | positive regulation of fat cell differentiation | 46/8552 | 66/18723 | 6.72e-05 | 5.11e-04 | 46 |
GO:00338655 | Esophagus | ESCC | nucleoside bisphosphate metabolic process | 77/8552 | 128/18723 | 6.71e-04 | 3.55e-03 | 77 |
GO:00338755 | Esophagus | ESCC | ribonucleoside bisphosphate metabolic process | 77/8552 | 128/18723 | 6.71e-04 | 3.55e-03 | 77 |
GO:00340325 | Esophagus | ESCC | purine nucleoside bisphosphate metabolic process | 77/8552 | 128/18723 | 6.71e-04 | 3.55e-03 | 77 |
GO:00442827 | Esophagus | ESCC | small molecule catabolic process | 201/8552 | 376/18723 | 1.35e-03 | 6.41e-03 | 201 |
GO:00455984 | Esophagus | ESCC | regulation of fat cell differentiation | 79/8552 | 139/18723 | 5.23e-03 | 1.97e-02 | 79 |
GO:00160427 | Esophagus | ESCC | lipid catabolic process | 168/8552 | 320/18723 | 7.97e-03 | 2.84e-02 | 168 |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SULT1E1 | SNV | Missense_Mutation | novel | c.305G>A | p.Arg102Lys | p.R102K | P49888 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
SULT1E1 | SNV | Missense_Mutation | c.796N>T | p.His266Tyr | p.H266Y | P49888 | protein_coding | tolerated(0.41) | benign(0.007) | TCGA-AO-A0JC-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | fluorouracil | SD | |
SULT1E1 | SNV | Missense_Mutation | rs769898905 | c.403G>A | p.Ala135Thr | p.A135T | P49888 | protein_coding | tolerated(0.09) | possibly_damaging(0.895) | TCGA-E2-A150-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD |
SULT1E1 | SNV | Missense_Mutation | novel | c.289G>A | p.Glu97Lys | p.E97K | P49888 | protein_coding | tolerated(0.98) | benign(0.003) | TCGA-E2-A2P6-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | anastrozole | SD |
SULT1E1 | SNV | Missense_Mutation | c.488A>C | p.Gln163Pro | p.Q163P | P49888 | protein_coding | tolerated(0.09) | benign(0.311) | TCGA-EK-A2R9-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
SULT1E1 | SNV | Missense_Mutation | c.244G>C | p.Glu82Gln | p.E82Q | P49888 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-A6-5664-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | fluorouracil | SD | |
SULT1E1 | SNV | Missense_Mutation | c.299C>A | p.Ser100Tyr | p.S100Y | P49888 | protein_coding | deleterious(0.01) | probably_damaging(0.986) | TCGA-AA-3510-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
SULT1E1 | SNV | Missense_Mutation | c.763N>G | p.Met255Val | p.M255V | P49888 | protein_coding | deleterious(0) | probably_damaging(0.911) | TCGA-AU-6004-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
SULT1E1 | SNV | Missense_Mutation | c.423N>A | p.Phe141Leu | p.F141L | P49888 | protein_coding | deleterious(0.02) | possibly_damaging(0.623) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR | |
SULT1E1 | SNV | Missense_Mutation | c.299N>A | p.Ser100Tyr | p.S100Y | P49888 | protein_coding | deleterious(0.01) | probably_damaging(0.986) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
Page: 1 2 3 4 5 6 7 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
6783 | SULT1E1 | ENZYME, DRUGGABLE GENOME | acetaminophen | ACETAMINOPHEN | 23462933,26049587 |
Page: 1 |