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Gene: SULT1A4 |
Gene summary for SULT1A4 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | SULT1A4 | Gene ID | 445329 |
| Gene name | sulfotransferase family 1A member 4 | |
| Gene Alias | HAST3 | |
| Cytomap | 16p11.2 | |
| Gene Type | protein-coding | GO ID | GO:0000165 | UniProtAcc | P0DMM9 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 445329 | SULT1A4 | HTA11_3410_2000001011 | Human | Colorectum | AD | 1.83e-02 | 1.08e-01 | 0.0155 |
| 445329 | SULT1A4 | HTA11_2487_2000001011 | Human | Colorectum | SER | 5.21e-27 | 7.17e-01 | -0.1808 |
| 445329 | SULT1A4 | HTA11_1938_2000001011 | Human | Colorectum | AD | 3.84e-10 | 3.30e-01 | -0.0811 |
| 445329 | SULT1A4 | HTA11_78_2000001011 | Human | Colorectum | AD | 8.38e-10 | 2.91e-01 | -0.1088 |
| 445329 | SULT1A4 | HTA11_347_2000001011 | Human | Colorectum | AD | 1.20e-28 | 5.19e-01 | -0.1954 |
| 445329 | SULT1A4 | HTA11_411_2000001011 | Human | Colorectum | SER | 1.35e-12 | 7.74e-01 | -0.2602 |
| 445329 | SULT1A4 | HTA11_2112_2000001011 | Human | Colorectum | SER | 7.77e-16 | 8.61e-01 | -0.2196 |
| 445329 | SULT1A4 | HTA11_3361_2000001011 | Human | Colorectum | AD | 3.54e-19 | 4.74e-01 | -0.1207 |
| 445329 | SULT1A4 | HTA11_83_2000001011 | Human | Colorectum | SER | 1.07e-20 | 5.95e-01 | -0.1526 |
| 445329 | SULT1A4 | HTA11_696_2000001011 | Human | Colorectum | AD | 8.56e-30 | 5.39e-01 | -0.1464 |
| 445329 | SULT1A4 | HTA11_866_2000001011 | Human | Colorectum | AD | 2.83e-15 | 3.16e-01 | -0.1001 |
| 445329 | SULT1A4 | HTA11_1391_2000001011 | Human | Colorectum | AD | 2.25e-23 | 6.34e-01 | -0.059 |
| 445329 | SULT1A4 | HTA11_2992_2000001011 | Human | Colorectum | SER | 2.54e-11 | 5.66e-01 | -0.1706 |
| 445329 | SULT1A4 | HTA11_5212_2000001011 | Human | Colorectum | AD | 2.13e-12 | 4.96e-01 | -0.2061 |
| 445329 | SULT1A4 | HTA11_5216_2000001011 | Human | Colorectum | SER | 2.49e-08 | 5.15e-01 | -0.1462 |
| 445329 | SULT1A4 | HTA11_546_2000001011 | Human | Colorectum | AD | 1.74e-13 | 4.02e-01 | -0.0842 |
| 445329 | SULT1A4 | HTA11_9341_2000001011 | Human | Colorectum | SER | 5.61e-03 | 3.31e-01 | -0.00410000000000005 |
| 445329 | SULT1A4 | HTA11_7862_2000001011 | Human | Colorectum | AD | 1.24e-02 | 1.60e-01 | -0.0179 |
| 445329 | SULT1A4 | HTA11_866_3004761011 | Human | Colorectum | AD | 6.26e-04 | 1.42e-01 | 0.096 |
| 445329 | SULT1A4 | HTA11_4255_2000001011 | Human | Colorectum | SER | 3.40e-02 | 3.08e-01 | 0.0446 |
| Page: 1 2 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Colorectum (GSE201348) |  | FAP: Familial adenomatous polyposis |
| CRC: Colorectal cancer | ||
| Colorectum (HTA11) |  | AD: Adenomas |
| SER: Sessile serrated lesions | ||
| MSI-H: Microsatellite-high colorectal cancer | ||
| MSS: Microsatellite stable colorectal cancer |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:0009150 | Colorectum | AD | purine ribonucleotide metabolic process | 142/3918 | 368/18723 | 4.29e-15 | 1.17e-12 | 142 |
| GO:0006163 | Colorectum | AD | purine nucleotide metabolic process | 149/3918 | 396/18723 | 1.08e-14 | 2.80e-12 | 149 |
| GO:0072521 | Colorectum | AD | purine-containing compound metabolic process | 153/3918 | 416/18723 | 4.34e-14 | 1.01e-11 | 153 |
| GO:0009259 | Colorectum | AD | ribonucleotide metabolic process | 144/3918 | 385/18723 | 5.25e-14 | 1.13e-11 | 144 |
| GO:0019693 | Colorectum | AD | ribose phosphate metabolic process | 145/3918 | 396/18723 | 3.01e-13 | 5.71e-11 | 145 |
| GO:0009117 | Colorectum | AD | nucleotide metabolic process | 168/3918 | 489/18723 | 2.20e-12 | 3.36e-10 | 168 |
| GO:0006753 | Colorectum | AD | nucleoside phosphate metabolic process | 169/3918 | 497/18723 | 4.99e-12 | 6.98e-10 | 169 |
| GO:0019439 | Colorectum | AD | aromatic compound catabolic process | 146/3918 | 467/18723 | 7.48e-08 | 3.84e-06 | 146 |
| GO:1901361 | Colorectum | AD | organic cyclic compound catabolic process | 153/3918 | 495/18723 | 8.23e-08 | 4.18e-06 | 153 |
| GO:0044282 | Colorectum | AD | small molecule catabolic process | 118/3918 | 376/18723 | 1.05e-06 | 3.55e-05 | 118 |
| GO:0070997 | Colorectum | AD | neuron death | 114/3918 | 361/18723 | 1.13e-06 | 3.72e-05 | 114 |
| GO:1901214 | Colorectum | AD | regulation of neuron death | 99/3918 | 319/18723 | 1.26e-05 | 2.76e-04 | 99 |
| GO:0006066 | Colorectum | AD | alcohol metabolic process | 106/3918 | 353/18723 | 3.02e-05 | 5.57e-04 | 106 |
| GO:0006790 | Colorectum | AD | sulfur compound metabolic process | 101/3918 | 339/18723 | 6.46e-05 | 1.07e-03 | 101 |
| GO:1901215 | Colorectum | AD | negative regulation of neuron death | 67/3918 | 208/18723 | 8.81e-05 | 1.35e-03 | 67 |
| GO:0009410 | Colorectum | AD | response to xenobiotic stimulus | 128/3918 | 462/18723 | 2.69e-04 | 3.31e-03 | 128 |
| GO:0034310 | Colorectum | AD | primary alcohol catabolic process | 9/3918 | 15/18723 | 1.11e-03 | 1.01e-02 | 9 |
| GO:0033865 | Colorectum | AD | nucleoside bisphosphate metabolic process | 42/3918 | 128/18723 | 1.12e-03 | 1.02e-02 | 42 |
| GO:0033875 | Colorectum | AD | ribonucleoside bisphosphate metabolic process | 42/3918 | 128/18723 | 1.12e-03 | 1.02e-02 | 42 |
| GO:0034032 | Colorectum | AD | purine nucleoside bisphosphate metabolic process | 42/3918 | 128/18723 | 1.12e-03 | 1.02e-02 | 42 |
| Page: 1 2 3 4 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| 445329 | SULT1A4 | ENZYME | morphine | MORPHINE | ||
| 445329 | SULT1A4 | ENZYME | acetaminophen | ACETAMINOPHEN | 26049587 |
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