![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: SUGP1 |
Gene summary for SUGP1 |
![]() |
Gene information | Species | Human | Gene symbol | SUGP1 | Gene ID | 57794 |
Gene name | SURP and G-patch domain containing 1 | |
Gene Alias | F23858 | |
Cytomap | 19p13.11 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q8IWZ8 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
57794 | SUGP1 | HCC1_Meng | Human | Liver | HCC | 2.80e-17 | -2.17e-02 | 0.0246 |
57794 | SUGP1 | HCC2_Meng | Human | Liver | HCC | 4.13e-08 | 3.36e-02 | 0.0107 |
57794 | SUGP1 | HCC1 | Human | Liver | HCC | 4.90e-03 | 3.22e+00 | 0.5336 |
57794 | SUGP1 | HCC2 | Human | Liver | HCC | 8.58e-06 | 3.20e+00 | 0.5341 |
57794 | SUGP1 | S014 | Human | Liver | HCC | 2.31e-11 | 3.46e-01 | 0.2254 |
57794 | SUGP1 | S015 | Human | Liver | HCC | 3.68e-12 | 4.15e-01 | 0.2375 |
57794 | SUGP1 | S016 | Human | Liver | HCC | 1.56e-17 | 4.25e-01 | 0.2243 |
57794 | SUGP1 | S027 | Human | Liver | HCC | 4.67e-02 | 3.04e-01 | 0.2446 |
57794 | SUGP1 | S028 | Human | Liver | HCC | 1.82e-04 | 2.30e-01 | 0.2503 |
57794 | SUGP1 | S029 | Human | Liver | HCC | 2.25e-09 | 3.06e-01 | 0.2581 |
Page: 1 |
![]() |
Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000838022 | Liver | HCC | RNA splicing | 313/7958 | 434/18723 | 1.36e-36 | 1.73e-33 | 313 |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SUGP1 | SNV | Missense_Mutation | c.1179N>C | p.Lys393Asn | p.K393N | Q8IWZ8 | protein_coding | deleterious(0.04) | probably_damaging(0.915) | TCGA-A2-A0D2-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD | |
SUGP1 | SNV | Missense_Mutation | c.1924N>T | p.Arg642Trp | p.R642W | Q8IWZ8 | protein_coding | deleterious(0.02) | probably_damaging(0.99) | TCGA-A2-A0EN-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | SD | |
SUGP1 | SNV | Missense_Mutation | c.1270G>A | p.Glu424Lys | p.E424K | Q8IWZ8 | protein_coding | tolerated(0.49) | benign(0.007) | TCGA-AN-A0FJ-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
SUGP1 | SNV | Missense_Mutation | c.1716G>C | p.Lys572Asn | p.K572N | Q8IWZ8 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AO-A128-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD | |
SUGP1 | SNV | Missense_Mutation | novel | c.740N>G | p.Lys247Arg | p.K247R | Q8IWZ8 | protein_coding | tolerated(0.98) | benign(0) | TCGA-D8-A1XK-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicine+cyclophosphamide | SD |
SUGP1 | SNV | Missense_Mutation | c.1213N>T | p.Asp405Tyr | p.D405Y | Q8IWZ8 | protein_coding | tolerated(0.43) | benign(0.118) | TCGA-D8-A1XZ-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Hormone Therapy | tamoxiphen+anastrozolum | SD | |
SUGP1 | SNV | Missense_Mutation | c.1401N>A | p.Asp467Glu | p.D467E | Q8IWZ8 | protein_coding | tolerated(1) | benign(0.001) | TCGA-D8-A27N-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | taxol+adriamycin+cyclophosphamide+herceptin | SD | |
SUGP1 | SNV | Missense_Mutation | novel | c.291N>T | p.Gln97His | p.Q97H | Q8IWZ8 | protein_coding | deleterious(0) | probably_damaging(0.993) | TCGA-LQ-A4E4-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Hormone Therapy | anastrozole | PD |
SUGP1 | deletion | Frame_Shift_Del | novel | c.640delT | p.Tyr214ThrfsTer28 | p.Y214Tfs*28 | Q8IWZ8 | protein_coding | TCGA-AN-A04D-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
SUGP1 | insertion | Frame_Shift_Ins | novel | c.7_8insAGTGCATTAATGAGAAAATATTTACAAAAACTTACGTA | p.Leu3GlnfsTer39 | p.L3Qfs*39 | Q8IWZ8 | protein_coding | TCGA-AQ-A04J-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD |
Page: 1 2 3 4 5 6 7 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |