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Gene: STOML1 |
Gene summary for STOML1 |
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Gene information | Species | Human | Gene symbol | STOML1 | Gene ID | 9399 |
Gene name | stomatin like 1 | |
Gene Alias | SLP-1 | |
Cytomap | 15q24.1 | |
Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | Q53HB6 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
9399 | STOML1 | HCC1_Meng | Human | Liver | HCC | 6.07e-09 | 6.48e-03 | 0.0246 |
9399 | STOML1 | HCC2_Meng | Human | Liver | HCC | 2.54e-04 | 3.31e-02 | 0.0107 |
9399 | STOML1 | S014 | Human | Liver | HCC | 3.74e-10 | 3.54e-01 | 0.2254 |
9399 | STOML1 | S015 | Human | Liver | HCC | 2.40e-11 | 4.39e-01 | 0.2375 |
9399 | STOML1 | S016 | Human | Liver | HCC | 3.97e-08 | 3.27e-01 | 0.2243 |
9399 | STOML1 | S027 | Human | Liver | HCC | 1.57e-06 | 4.47e-01 | 0.2446 |
9399 | STOML1 | S028 | Human | Liver | HCC | 3.78e-13 | 5.57e-01 | 0.2503 |
9399 | STOML1 | S029 | Human | Liver | HCC | 3.77e-10 | 5.21e-01 | 0.2581 |
9399 | STOML1 | C04 | Human | Oral cavity | OSCC | 3.37e-05 | 4.42e-01 | 0.2633 |
9399 | STOML1 | C21 | Human | Oral cavity | OSCC | 1.62e-20 | 6.73e-01 | 0.2678 |
9399 | STOML1 | C30 | Human | Oral cavity | OSCC | 1.45e-22 | 1.10e+00 | 0.3055 |
9399 | STOML1 | C43 | Human | Oral cavity | OSCC | 1.81e-14 | 2.59e-01 | 0.1704 |
9399 | STOML1 | C46 | Human | Oral cavity | OSCC | 1.84e-13 | 3.72e-01 | 0.1673 |
9399 | STOML1 | C51 | Human | Oral cavity | OSCC | 5.71e-11 | 5.89e-01 | 0.2674 |
9399 | STOML1 | C57 | Human | Oral cavity | OSCC | 8.38e-08 | 2.98e-01 | 0.1679 |
9399 | STOML1 | C06 | Human | Oral cavity | OSCC | 5.36e-03 | 6.48e-01 | 0.2699 |
9399 | STOML1 | C08 | Human | Oral cavity | OSCC | 7.18e-10 | 2.41e-01 | 0.1919 |
9399 | STOML1 | LN46 | Human | Oral cavity | OSCC | 1.62e-04 | 2.76e-01 | 0.1666 |
9399 | STOML1 | LP15 | Human | Oral cavity | LP | 1.85e-04 | 7.56e-01 | 0.2174 |
9399 | STOML1 | SYSMH1 | Human | Oral cavity | OSCC | 2.71e-06 | 1.64e-01 | 0.1127 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:001087621 | Liver | HCC | lipid localization | 228/7958 | 448/18723 | 1.80e-04 | 1.41e-03 | 228 |
GO:000686921 | Liver | HCC | lipid transport | 198/7958 | 398/18723 | 1.92e-03 | 9.78e-03 | 198 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
STOML1 | SNV | Missense_Mutation | rs776788505 | c.664N>A | p.Val222Met | p.V222M | Q9UBI4 | protein_coding | deleterious(0.02) | probably_damaging(0.985) | TCGA-A2-A04V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | PD |
STOML1 | SNV | Missense_Mutation | novel | c.221C>A | p.Ser74Tyr | p.S74Y | Q9UBI4 | protein_coding | deleterious(0) | probably_damaging(0.968) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
STOML1 | insertion | In_Frame_Ins | novel | c.251_252insTCCCTTTCTCCCCTTTTCTTCTGCAAGACTTTCATCCATGCT | p.Thr84_Tyr85insProPheLeuProPheSerSerAlaArgLeuSerSerMetLeu | p.T84_Y85insPFLPFSSARLSSML | Q9UBI4 | protein_coding | TCGA-A8-A095-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | 5-fluorouracil | CR | ||
STOML1 | SNV | Missense_Mutation | novel | c.748N>C | p.Ser250Arg | p.S250R | Q9UBI4 | protein_coding | tolerated(0.24) | benign(0.072) | TCGA-AA-3947-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
STOML1 | SNV | Missense_Mutation | c.763G>A | p.Ala255Thr | p.A255T | Q9UBI4 | protein_coding | tolerated(0.18) | benign(0.014) | TCGA-AZ-6598-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
STOML1 | SNV | Missense_Mutation | novel | c.640N>A | p.Arg214Ser | p.R214S | Q9UBI4 | protein_coding | tolerated(0.05) | possibly_damaging(0.499) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
STOML1 | SNV | Missense_Mutation | c.442N>T | p.Arg148Cys | p.R148C | Q9UBI4 | protein_coding | deleterious(0.03) | benign(0.437) | TCGA-D5-6540-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
STOML1 | deletion | Frame_Shift_Del | rs769286917 | c.1114delN | p.Ala372ProfsTer3 | p.A372Pfs*3 | Q9UBI4 | protein_coding | TCGA-D5-6540-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | ||
STOML1 | SNV | Missense_Mutation | novel | c.410N>G | p.Ala137Gly | p.A137G | Q9UBI4 | protein_coding | tolerated(0.29) | benign(0.093) | TCGA-AJ-A3EK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | CR |
STOML1 | SNV | Missense_Mutation | novel | c.691N>A | p.Ala231Thr | p.A231T | Q9UBI4 | protein_coding | tolerated(0.56) | benign(0.003) | TCGA-AP-A1DK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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