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Gene: STN1 |
Gene summary for STN1 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | STN1 | Gene ID | 79991 |
| Gene name | STN1 subunit of CST complex | |
| Gene Alias | AAF-44 | |
| Cytomap | 10q24.33 | |
| Gene Type | protein-coding | GO ID | GO:0000723 | UniProtAcc | Q9H668 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 79991 | STN1 | LZE4T | Human | Esophagus | ESCC | 3.78e-08 | 2.32e-01 | 0.0811 |
| 79991 | STN1 | LZE7T | Human | Esophagus | ESCC | 3.98e-06 | 3.01e-01 | 0.0667 |
| 79991 | STN1 | LZE8T | Human | Esophagus | ESCC | 2.72e-03 | 1.56e-01 | 0.067 |
| 79991 | STN1 | LZE20T | Human | Esophagus | ESCC | 7.18e-07 | 1.97e-01 | 0.0662 |
| 79991 | STN1 | LZE24T | Human | Esophagus | ESCC | 6.51e-29 | 6.49e-01 | 0.0596 |
| 79991 | STN1 | LZE21T | Human | Esophagus | ESCC | 8.02e-04 | 2.06e-01 | 0.0655 |
| 79991 | STN1 | LZE6T | Human | Esophagus | ESCC | 9.07e-08 | 3.26e-01 | 0.0845 |
| 79991 | STN1 | NAFLD1 | Human | Liver | NAFLD | 1.48e-02 | 1.88e-01 | -0.04 |
| 79991 | STN1 | HCC1 | Human | Liver | HCC | 1.89e-02 | 1.43e+00 | 0.5336 |
| 79991 | STN1 | HCC2 | Human | Liver | HCC | 1.30e-15 | 3.17e+00 | 0.5341 |
| 79991 | STN1 | S014 | Human | Liver | HCC | 1.36e-21 | 4.67e-01 | 0.2254 |
| 79991 | STN1 | S015 | Human | Liver | HCC | 6.83e-29 | 7.11e-01 | 0.2375 |
| 79991 | STN1 | S016 | Human | Liver | HCC | 1.04e-22 | 5.13e-01 | 0.2243 |
| 79991 | STN1 | S027 | Human | Liver | HCC | 2.89e-15 | 6.94e-01 | 0.2446 |
| 79991 | STN1 | S028 | Human | Liver | HCC | 5.39e-21 | 5.63e-01 | 0.2503 |
| 79991 | STN1 | S029 | Human | Liver | HCC | 3.57e-22 | 6.40e-01 | 0.2581 |
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| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Liver |  | HCC: Hepatocellular carcinoma |
| NAFLD: Non-alcoholic fatty liver disease |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:19907788 | Cervix | CC | protein localization to cell periphery | 78/2311 | 333/18723 | 1.22e-08 | 9.73e-07 | 78 |
| GO:00343298 | Cervix | CC | cell junction assembly | 88/2311 | 420/18723 | 3.42e-07 | 1.38e-05 | 88 |
| GO:00160498 | Cervix | CC | cell growth | 92/2311 | 482/18723 | 1.16e-05 | 2.49e-04 | 92 |
| GO:00988767 | Cervix | CC | vesicle-mediated transport to the plasma membrane | 34/2311 | 136/18723 | 3.75e-05 | 5.91e-04 | 34 |
| GO:00901509 | Cervix | CC | establishment of protein localization to membrane | 54/2311 | 260/18723 | 7.67e-05 | 1.05e-03 | 54 |
| GO:00015588 | Cervix | CC | regulation of cell growth | 77/2311 | 414/18723 | 1.40e-04 | 1.70e-03 | 77 |
| GO:19018886 | Cervix | CC | regulation of cell junction assembly | 42/2311 | 204/18723 | 5.50e-04 | 5.29e-03 | 42 |
| GO:00519603 | Cervix | CC | regulation of nervous system development | 77/2311 | 443/18723 | 1.13e-03 | 9.30e-03 | 77 |
| GO:00519622 | Cervix | CC | positive regulation of nervous system development | 48/2311 | 272/18723 | 6.60e-03 | 3.65e-02 | 48 |
| GO:1990778 | Colorectum | AD | protein localization to cell periphery | 129/3918 | 333/18723 | 5.51e-14 | 1.15e-11 | 129 |
| GO:0090150 | Colorectum | AD | establishment of protein localization to membrane | 100/3918 | 260/18723 | 6.01e-11 | 6.33e-09 | 100 |
| GO:0034329 | Colorectum | AD | cell junction assembly | 136/3918 | 420/18723 | 2.02e-08 | 1.15e-06 | 136 |
| GO:0098876 | Colorectum | AD | vesicle-mediated transport to the plasma membrane | 57/3918 | 136/18723 | 2.30e-08 | 1.27e-06 | 57 |
| GO:0016049 | Colorectum | AD | cell growth | 143/3918 | 482/18723 | 2.83e-06 | 8.09e-05 | 143 |
| GO:0001558 | Colorectum | AD | regulation of cell growth | 124/3918 | 414/18723 | 7.67e-06 | 1.86e-04 | 124 |
| GO:1901888 | Colorectum | AD | regulation of cell junction assembly | 61/3918 | 204/18723 | 1.50e-03 | 1.27e-02 | 61 |
| GO:0050808 | Colorectum | AD | synapse organization | 112/3918 | 426/18723 | 4.25e-03 | 2.92e-02 | 112 |
| GO:1902414 | Colorectum | AD | protein localization to cell junction | 31/3918 | 94/18723 | 4.30e-03 | 2.95e-02 | 31 |
| GO:0050807 | Colorectum | AD | regulation of synapse organization | 60/3918 | 211/18723 | 5.67e-03 | 3.64e-02 | 60 |
| GO:0099072 | Colorectum | AD | regulation of postsynaptic membrane neurotransmitter receptor levels | 22/3918 | 62/18723 | 5.72e-03 | 3.64e-02 | 22 |
| Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| STN1 | SNV | Missense_Mutation | rs146909879 | c.149A>G | p.Asn50Ser | p.N50S | Q9H668 | protein_coding | deleterious(0.02) | probably_damaging(0.918) | TCGA-A2-A0EY-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD |
| STN1 | SNV | Missense_Mutation | c.542N>A | p.Pro181His | p.P181H | Q9H668 | protein_coding | deleterious(0.04) | probably_damaging(1) | TCGA-BH-A0BP-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
| STN1 | SNV | Missense_Mutation | c.284N>G | p.Glu95Gly | p.E95G | Q9H668 | protein_coding | tolerated(0.28) | benign(0.096) | TCGA-BH-A0H9-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD | |
| STN1 | SNV | Missense_Mutation | c.487C>G | p.Gln163Glu | p.Q163E | Q9H668 | protein_coding | deleterious(0) | probably_damaging(0.975) | TCGA-GM-A2D9-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD | |
| STN1 | deletion | Frame_Shift_Del | c.990_999delNNNNNNNNNN | p.Cys330Ter | p.C330* | Q9H668 | protein_coding | TCGA-BH-A0B4-01 | Breast | breast invasive carcinoma | Male | >=65 | III/IV | Hormone Therapy | tamoxiphen | SD | |||
| STN1 | SNV | Missense_Mutation | novel | c.290T>C | p.Val97Ala | p.V97A | Q9H668 | protein_coding | tolerated(0.77) | benign(0) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
| STN1 | SNV | Missense_Mutation | rs183917764 | c.416N>A | p.Arg139His | p.R139H | Q9H668 | protein_coding | tolerated(0.12) | benign(0.168) | TCGA-EK-A2RO-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
| STN1 | SNV | Missense_Mutation | c.949N>T | p.His317Tyr | p.H317Y | Q9H668 | protein_coding | tolerated(0.35) | benign(0.013) | TCGA-AA-3977-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
| STN1 | SNV | Missense_Mutation | rs780655414 | c.1010C>T | p.Pro337Leu | p.P337L | Q9H668 | protein_coding | tolerated(0.52) | possibly_damaging(0.47) | TCGA-AU-6004-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| STN1 | deletion | Frame_Shift_Del | c.831delN | p.Gly278AspfsTer16 | p.G278Dfs*16 | Q9H668 | protein_coding | TCGA-CM-6674-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
| Page: 1 2 3 4 |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| 79991 | STN1 | ENZYME | atenolol | ATENOLOL | 31327267 |
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